What is Astragalus?what is function of Astragalus?

article content dot Contents:

applications dot Research Update:Anti-aging effect of astragalosides.

Astragalus Root Extract.ASTRAGALUS MEMBRANACEUS EXTRACT.CAS 94166-93-5 EINECS No 303-391-9 Astragalus Root Extracts.Astragalosides.CAS NO 85085-21-8 Tragacanth Astragalus Gummifer Extract,Astragalus Polysaccharides.Astragalus mongholicus photo picture image Aging is a natural phenomenon that has a common symptom; motor and memory dysfunction. Also,there are a lot of assumptions concerning senescence,such as free radical degeneration and immune system dysfunction.
 Astragalus is a kind of Chinese tonic herbs. Its active part is astragalosides (AST) and polysaccharides which are extracted from the root of Astragalus membranceus(Fisch) Bge. Previous studies from our laboratory showed that AST possessed an anti-aging effect, probably being related to its anti-oxidative properties. A pilot study from our laboratory demonstrated that AST had an immunomodulatory effect. However, the relationship of anti-aging effect of AST to immune response is unknown. The present study was therefore designed to investigate the anti-aging effect of AST and its relation with immunity, exploiting D-gal-induced senescent mice and the middle-aged mice.
 Some Scientists from China Rotating rod test and step-down type passive avoidance test were performed to determine the effects of AST on motor and memory of D-galactose (D-gal)-induced senescent mice and the middle-aged mice. The proliferative response of splenocytes induced by Con A or LPS, IL-2 production of splenocytes induced by ConA of D-gal-treated mice and the middle-aged mice were also measured.
 AST (40 mg;kg-1;d-1,ig, for 10 weeks) was found to ameliorate age-related alternations in both motor response and memory, enhance the deteriorated cellular immunity in D-gal-treated mice and the pre-aged (17-month-old) mice.
 Conclusion: AST has an anti-aging effect on D-gal-induced senescent mice and has the effect of delaying senility of the middle-aged mice, which was related to its improvement of brain function and immunomodulatory effects.

Last PageNext Page

reference dot Reference:

citations 1.What is Astragalus?what is function of Astragalus?
To Top

last edit date:25th,Feb.2010.