What is Cnidium Monnier Extracts?Pharmacology Actions and application of Cnidium Monnier and Osthol,C15H16O3,Osthola?

Safety and Acute toxicity

Common cnidium fruit Fructus Cnidii Osthol cnidium monnieri Cnidium Seeds Semen Cnidii Cnidium bhutanicum She ChuangShi SheSu Wild Carrot Seeds CNIDIUM MONNIERI FRUIT EXTRACT Osthole 484-12-8 photo picture image Osthol:

Chemical Name: Coumarin,7-methoxy-8-(3-methyl-2-butenyl)-
CAS: 484-12-8.Molecular Formula: C15-H16-O3.Weight: 244.31
Synonyms: 2H-1-Benzopyran-2-one,7-methoxy-8-(3-methyl-2-butenyl)-;7-Methoxy-8-isopentenylcoumarin;7-Methoxy-8-(3-methyl-2-butenyl)-coumarin;Osthol;Osthole;Ostol;Ostole.

Acute toxicity(LD50):

LD50-Lethal dose,50 percent kill.Oral.Rodent-rat.2905mg/kg.
Behavioral:convulsions or effect on seizure threshold.
Behavioral:muscle contraction or spasticity.
Lungs,Thorax,or Respiration-dyspnea.
Reference:IJMRAQ Indian Journal of Medical Research.(Indian Council of Medicial Research,Ansari Nagar,New Delhi 110 029,India) V.1-1913-Volume(issue)/page/year:55,241,1967.

LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-rat.600mg/kg.
Toxic effects:
Behavioral:convulsions or effect on seizure threshold.
Behavioral:muscle contraction or spasticity.
Lungs,Thorax,or Respiration-dyspne.
Reference:IJMRAQ Indian Journal of Medical Research.(Indian Council of Medicial Research,Ansari Nagar,New Delhi 110 029,India) V.1-1913-Volume(issue)/page/year:55,241,1967.

LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.190mg/kg.
Toxic effects:
Behavioral:convulsions or effect on seizure threshold.
Behavioral:muscle contraction or spasticity.
Lungs,Thorax,or Respiration-dyspne.
Reference:IJMRAQ Indian Journal of Medical Research.(Indian Council of Medicial Research,Ansari Nagar,New Delhi 110 029,India) V.1-1913-Volume(issue)/page/year:55,241,1967.

LD50-Lethal dose,50 percent kill.Subcutaneous.Rodent-mouse.16mg/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:PCJOAU Pharmaceutical Chemistry Journal(English Translation).Trnaslation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013)nO.1-1967-Volume(issue)/page/year:11,331,1977.

LD50-Lethal dose,50 percent kill.Intravenous.Mammal-dog. >40mg/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.(Heymans Institute of Pharmacology,De Pintelaan 185,B-9000 Ghent,Belgium) V.4-1898-Volume(issue)/page/year:150,425,1964.

LD50-Lethal dose,50 percent kill.Subcutaneous.Rodent-rabbit. >70mg/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.(Heymans Institute of Pharmacology,De Pintelaan 185,B-9000 Ghent,Belgium) V.4-1898-Volume(issue)/page/year:138,400,1962.

LDLo-Lowest published lethal dose.Intravenous.Rodent-rabbit.25mg/kg.
Toxic effects:
Behavioral:convulsions or effect on seizure threshold.
Lungs,Thorax,or Respiration-respiratory stimulation.
Lungs,Thorax,or Respiration-other changes.
Reference:AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.(Heymans Institute of Pharmacology,De Pintelaan 185,B-9000 Ghent,Belgium) V.4-1898-Volume(issue)/page/year:138,400,1962.

LD50-Lethal dose,50 percent kill.Oral.Rodent-guinea pig. >1 gm/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.(Heymans Institute of Pharmacology,De Pintelaan 185,B-9000 Ghent,Belgium) V.4-1898-Volume(issue)/page/year:150,425,1964.