What is CoQ10?Heart Energy Engine and More.

Supplementation and Safety.

Coenzyme Q10 CAS 303-98-0 photo picture image CoQ10's safety has been evaluated. Doses of 30-60 mg/day are generally recommended to prevent CoQ10 deficiency and to maintain normal serum concentrations of 0.7-1.0 ug/mL (micrograms per milliliter). However, therapeutic doses of 100-200 mg/day are advocated for the treatment of chronic heart disease. These higher doses may achieve serum concentrations of 2.0-3.0 ug/mL, reported by some investigators to have a positive impact on cardiovascular health. The dosage in a Parkinson's disease study ranged from 300-1200 mg/day, taken for 16 months. The group that received the largest dose of CoQ10 (1200 mg/day) displayed less of a decline in mental function, motor function, and ability to carry out activities of daily living.
If CoQ10 is going to be effective, adequate blood levels must be maintained for a prolonged period.

CoQ10 is absorbed slowly. Absorption is dependent on the presence of fat in the gastrointestinal (g.i.) tract. Peak plasma levels are attained within 5-10 hours following oral administration. CoQ10 is primarily excreted through the biliary tract, and over 60% of the oral dose is recovered in the feces.