What is CoQ10?Heart Energy Engine and More.
- What is CoQ10? Chemical Structure of Coenzyme Q10.
- Introduction: Coenzyme Q10.
- Benefits of Coenzyme Q10 or CoQ10(Co Q 10).
- Actions and Pharmacology for CoQ10(Co Q 10).
- Coenzyme Q10 in food.
- Coenzyme Q10 Deficiency.
- Effects of Statin Drugs on CoQ10(Co Q 10).
- Supplementation and Safety.
- Commercial Production of CoQ10(Co Q 10) Supplements.
- Biochemistry of CoQ10(Co Q 10).
- Indications and Usage.
- Research Update and Findings of Coenzyme Q10.
Commercial Production of CoQ10(Co Q 10) Supplements.:
There are currently two different manufacturing techniques being used to commercially produce coenzyme Q10. the solanesol method and the microbiological fermentation method used. The following is a brief summary of the two manufacturing methods:
The Solanesol Method:
The first CoQ10 to be admitted as a pharmaceutical ingredient was produced by the solanesol method. Plants from the Solanaceae family contain a nine-isoprenoid long alcohol known as solanesol. Solanesol is first extracted from the plant and is then converted to a ten-isoprenoid compound called decaprenol. During the final step, the decaprenol is reacted with hydroquninone to produce CoQ10. The CoQ10 produced by the solanesol method has a long history of safety and efficacy. The compound actually extracted from the tobacco leaf is the solanesol. The process begins with a n-hexane extraction. The solvent is removed by molecular distillation.
With this method, both trans and cis forms of CoQ10 are formed but subsequent purification steps reduce the quantity of cis isomers to below 0.5%, generally below 0.2%.Specification is not more than 0.5%.
Coenzyme Q10 produced by microbiological fermentation was also admitted as a pharmaceutical ingredient nd also has a long history of safety and efficacy. With the fermentation method, selected strains of microbes are placed in a fortified molasses-based carbohydrate medium where they produce CoQ10, as well as CoQ6, CoQ7, CoQ9 and CoQ11 during the fermentation process. The actual microbe used in the process is proprietary. The carbohydrate medium used is derived from sugar beets, but its exact composition is also proprietary.
Subsequent purification steps generally greatly reduce or eliminate the presence of other coenzyme homologues listed above. The USP specification for non-CoQ10 homologues is 1.0%. All of our material meets this requirement. Material produced in this manner is considered natural in the United States, Europe and China. The CoQ10 used is produced by microbiological fermentation, which is the all-trans isomer form.
Recently, there has been a great deal of controversy regarding differences in isomer (cis vs. trans) impurities contained commercially-available products. It is important to note that the compounds involved in the controversy are not hazardous. These impurities are compounds having positive health benefits but the health benefits are not as great as the benefits obtained from all-trans coenzyme Q10.
Coenzyme Q10 manufactured using the solanesol method has the potential to contain "cis" isomers in which the ten-isoprenoid unit tail is bent rather than straight. It is commonly believed that the bent tail limits the molecule's ability to penetrate cellular and organelle membranes. It is also possible that material made using the solanesol method contains some CoQ9. Subsequent purification steps generally greatly reduce or nearly eliminate the presence of these isomers.
Coenzyme Q10 manufactured by microbiological fermentation is 100% in the all-trans isomeric form, identical in structure of the coenzyme Q10 made by the human body. However, material made by microbiological fermentation has the potential to contain other homologues, sometimes referred to "related substances" such as CoQ7, CoQ8, and/or CoQ9. Subsequent purification steps generally greatly reduce or eliminate the presence of the other forms of coenzymes listed above.
All the coenzyme Q10 material utilized is guaranteed to be a minimum of 98% pure. This is considered a natural material and is in full compliance with the current United States Pharmacopeia/ National Formulary (USP/NF), European Pharmacopeia monographs and standards.
- What is CoQ10?Heart Energy Engine and More.
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