Salvia miltiorrhiza and Salvia Species:identification,traditional use,application research of Radix Salvia miltiorrhiza and its useful fraction components.
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Dosage, Toxicity,And Adverse Effects of Danshen.:
Acute Toxicity:LD50 (mice/intraperitoneal injection):[ 32.9g/kg~40.5g/kg.]
At the higher dosage levels, salvia may on rare occasions cause dry mouth, dizziness, lassitude, numbness, shortness of breath, and other symptoms that will usually disappear spontaneously without interrupting the treatment. Rare Chinese Materia Medica notes that salvia is not suitable for patients who have deficiency but not stasis, or deficiency accompanied by cold, or with tendency to bleed. However, most materia medica guides do not present these cautions. Salvia has very low acute toxicity, with an LD50 by injection of 40-80 g/kg.
The Pharmacopoeia of the People's Republic of China indicates a recommended dosage of 9-15 grams per daily dose in decoction form. In a few instances, higher doses are administered, up to 20 grams per day, in the treatment of inflammatory diseases, including viral hepatitis. According to English-Chinese Rare Chinese Materia Medica, up to 30-60 grams can be used in cases of angina and heat-type arthritis. The relatively high dosage of salvia, compared to most other Chinese herbs (typical dosage recommendations are 3-9 grams for many herbs) may be attributed to the relatively low level of active constituents and their poor solubility in water.
It is recommended that salvia, or its preparations used for treatment of poor blood circulation, not be combined with coumadin (Warfarin), as there is a possibility of increasing the anticoagulant effects (see: The interactions of herbs and drugs). In a literature survey conducted through October 2000, three cases of increased anticoagulant activity were reported in the literature in persons taking salvia along with Warfarin. Such effects may be rare and are likely to be dose dependent, as the mechanism appears to be a simple additive effect of anticoagulant activity of salvia along with that produced by Warfarin. Therefore, persons using coumadin should either avoid using salvia, or use it in relatively low dosage (not more than the equivalent of 6-9 grams per day in decoction) while paying attention to blood coagulation tests that are routinely performed for persons taking the drug.
Dosing:The doses listed below are based on scientific research, publications or traditional use. Because most herbs and supplements have not been thoroughly studied or monitored, safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients even within the same brand. Combination products often contain small amounts of each ingredient and may not be effective. Appropriate dosing should be discussed with a health care provider before starting therapy; always read the recommendations on a product?s label. The dosing for unproven uses should be approached cautiously, because scientific information is limited in these areas.
There are no standard or well-studied doses of danshen, and many different doses are used traditionally. Danshen is frequently used in combination with other herbs.
Adults (Aged 18 Or Older):
Internal administration: decoction of 5 to 15g, large dosages can reach up to 30g. 5:1 concentrated extract: 1 to 3 grams/day; (6 grams/day in large-dose use).
By mouth: Oral dosing has not been studied in well-conducted trials in humans, and therefore no specific dose can be recommended.
By injection: Danshen injections have been used for the treatment of ischemic stroke, but safety and effectiveness have not been established.
Children (Younger Than 18):There are not enough scientific data to recommend danshen for use in children, and danshen is not recommended because of potential side effects.
- 1.Salvia miltiorrhiza and Salvia Species:identification,traditional use,application research of Radix Salvia miltiorrhiza and its useful fraction components.
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