What is Siberian Ginseng? Siberian ginseng for Memory aid?Siberian Ginseng Extract.

Toxicity,Cautions and Contra-Indications.

Siberian Ginseng Extract.Siberian Ginseng Extract Eleutheroside INCI Name Acanthopanax Senticosus Extract EINECS ELINCS No.:296-164-8 CAS 92346-80-0 photo picture image No toxicity or side effects reported. Should not be taken with a high fever (above 39 deg C) or at a very high blood pressure (WHO stage 2).

Official Regulations and Medical References:
U.S.P.
Martindale
UK - British Herbal Compendium, p. 89
France - Accepted for specific indications No. 90/22
German - Comiison E ;1984, p. 124
PDR for Herbal Medicine - p. 824

Contraindications:
Eleuthero is generally considered by most herbalists in the United States to be milder in activity than the more stimulating root of Asian ginseng (Panax ginseng). There at least two studies in which it is recommended that eleuthero not be given to persons with a blood pressure in excess of 180/90 mm Hg. Presumably, this information prompted the Commission to note this possible adverse effect in some people. However, the glycosides contained in eleuthero have been shown to lower blood pressure.

Note:Eleuthero is different from both American ginseng and Panax ginseng. They are not interchangeable.

Reported side effects have been minimal with use of eleuthero. Mild, transient diarrhea has been reported in a very small number of users.

Eleuthero may:
cause insomnia in some people if taken too close to bedtime.
interact with certain medications, such as sedatives, barbiturates and anti psychotic drugs.
cause an increase in the effects of oral anti-diabetic medications.
Diabetic patients should ingest it solely under medical supervision.

Avoid:
in pregnancy and lactation.
use in patients with high blood pressure, liver or kidney disease.
combining this herb with other plants or substances that have a stimulating effect upon the central nervous system, such as Guaran??, Coffee, Ephedra (Ma Huang), mate or black tea.
use during acute phase of infections.
use at night in patients suffering from insomnia.
This herb is not prescribed for children, and should not be used for more than 3 weeks at one time. Avoid caffeine when using this herb.

Safety and Acute toxicity:

Acute Toxicity:Siberian Ginseng Extract.

Siberian Ginseng Ext.LD.50.lethal dose,50 percent death.Oral.Rodent.mice.10~30 grams/kg.
LD50.lethal dose,50 percent death.(PO) dogs,more than 33ml/KG for ethanolic extract.
Newall C, Anderson L, Phillipson JD. Herbal Medicines:A Guide for Health-care Professionals. London.The Pharmaceutical Press, 1996, 143.

Chronic Toxicity:Negligible

Toxicity studies in animals have demonstrated that Siberian ginseng extracts are virtually nontoxic.The LD50 (50 percent lethal dose) of the 33 percent ethanol extract of Siberian ginseng is 14.5 milliliters per kilogram in mice and greater than 20.0 milliliters per kilogram, and no long-term toxicity was observed in rats administered the 33 percent ethanol extract of Siberian ginseng at a daily dose of 5.0 milliliters per kilogram2 In human studies it was demonstrated that Siberian ginseng extracts (33 percent ethanol) are extremely well tolerated and side effects are quite infrequent. However, side effects often reported at higher dosages (4.56 milliliters three times daily) include insomnia, irritability, melancholy, and anxiety. Individuals with rheumatic heart disease have reported pericardial pain, headaches, palpitations, and elevations in blood pressure following the administration of Siberian ginseng.

Reference:

1.What is Siberian Ginseng? Siberian ginseng for Memory aid?Siberian Ginseng Extract.

last edit date:26th,Feb.2010.

Available Product

Name:Siberian Ginseng Extract
Serie No:S-024.
Specifications:Eleutherosides 0.8%.
INCI Name:ACANTHOPANAX SENTICOSUS EXTRACT
EINECS/ELINCS No.:296-164-8
CAS:92346-80-0
Chem/IUPAC Name:Acanthopanax Senticosus Extract is an extract of the roots of eleuthero ginseng,Acanthopanax senticosus,Araliaceae.

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