Fenugreek Trigonella Foenum-Graecum.Fenugreek Seed Extracts.
- Botanical Basic Data of Fenugreek.
- Narrative History of of Fenugreek.
- Nutritional Profile:Fenugreek Seed,Trigonella foenum-graecum (Leguminosae).
- Legends, Myths and Stories of Fenugreek.
- Description of of Fenugreek.
- Medicinal Action and Uses of Fenugreek.
- Common Uses of Fenugreek.
- Fenugreek Seed (Trigonella foenum-graecum; Hu Lu Ba) 10:1 Extract Powder.
- Pharmacology of Fenugreek Seed (Trigonella foenum-graecum; Hu Lu Ba).
- Safety of Fenugreek.
- Possible side effects and cautions of fenugreek.
- Trigonelline (nicotinic acid betaine) from fenugreek.
- How Search engine think about fenugreek.
- Research Update:Fenugreek.
- Photo Gallery of Foenum-graecum.
Trigonelline (nicotinic acid betaine) from fenugreek.:
Trigonelline as mammary glands estrogens:
Fenugreek is a unique herb rich in phyto-estrogens. Fenugreek aids in hormonal production, and facilitates the development of the mammary glands which 'feed' on estrogens. Trigonelline.
Traditionally used by Greek women to increase breast size, this unique herb has in recent times been scientifically proven to create a mastogenic effect, or growth effect, of healthy breast tissue. The phytochemical diosgenin and estrogenic isoflavones Trigonelline (nicotinic acid betaine) found in the seeds augment the production of estrogen in the body, essentially the key to fuller and shapelier breasts.
Trigonelline Phytochemical Info:
Synonyms:Betain nicotinate;Betaine nicotinate;Caffearin;3-Carboxy-1-methylpyridinium hydroxide inner salt;Coffearin;Coffearine;Gynesine;N-Methylnicotinate;N-Methylnicotinic acid;N'-Methylnicotinic acid;Nicotinic acid N-methylbetaine;Pyridinium,3-carboxy-1-methyl-,hydroxide,inner salt;Trigenolline;Trigonellin;1-Methylpyridinium-3-carboxylate monohydrate
CAS RN: 535-83-1 Formula: C7H7NO2 MW: 137.15
Determination of trigonelline by HPLC and study on its pharmacokinetics:
Methods: After ig of fenugreek extract and i.v. of trigonelline in rabbit, the biological samples could be well purified after precipitation of protein with methanol and acetonitrile. Asahipak NH2P-50 column was used, the mobile phase consisted of acetonitrile-water (90:10) at a flow-rate of 1.2 mL.min-1, and detection wavelength was set at UV 265 nm. The column temperature is 30 degrees C.
Results: The calibration curve was linear in the range from 0.98 mg.L-1 to 31.28 mg.L-1, with r = 0.9986, the detection limit of this method was 50 micrograms.L-1. The concentration-time curves of trigonelline in rabbits after ig and i.v. administration were shown to fit one-compartment and two-compartment open model, respectively. The main parameters after ig of fenugreek extract were as follow: T1/2(Ka) was 0.9 h, T1/2(Ke) was 2.2 h, V was 0.64 L.kg-1, AUC was 1.93 mg.min.L-1. The main parameters after i.v. of trigonelline were as follows: T1/2 alpha was 10.8 min, T1/2 beta was 44.0 min, K21 was 0.044 min-1, K10 was 0.026 min-1, K12 was 0.017 min-1, AUC was 931.0 mg.min.L-1.
Conclusion: Trigonelline showed a middle rate of absorption and fast rate of elimination in rabbit. Meanwhile, the method is simple, accurate, with a good reproducibility, and it provide a basic method for the investigation of trigonelline and fenugreek pharmacokinetics.
- Fenugreek Trigonella Foenum-Graecum.Fenugreek Seed Extracts.
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