Grape Seed Extract?Muscat, Red Wine Extract,Vitis Vinefera Seed Extract?A Powerful Antioxidant and More.
- Basic Botanical Data of Grape Seed.
- What Is Grape Seed Extract?
- Phytochemicals and content of Grape Seed?
- History and discovery of Grape Seed Extract?
- Important differences between Grape Seed and Pine Bark
- Health Benefits of Grape Seed Extract?
- What Does OPC Grape Seed Extract Do and How Does It Work?
- Famous benefits and Some known application of Grape Seed Extract.
- Research Summary of Grape Seed Extract.
- Grape Seed Extract, A Potent Antioxidant.
- Grape Seed Extract, Quickly Absorbed.
- About Anthocyanins and Proanthocyanins.
- Grape Seed Extract:Suggestions and Administration.
- Research Update:Grape Seed Extract and Grape Skin Extract.
- Photo Gallery of Vitis vinifera.
Research Summary of Grape Seed Extract.
Antitumor-promoting activity, described as highly significant, has been observed in animals treated with topical grape seed proanthocyanidins. Skin tumor incidence, multiplicity and volume were all significantly inhibited. These effects were attributed to inhibition of epidermal lipid peroxidation. Higher doses resulted in greater degrees of cancer inhibition.
An extract of grape seed proanthocyanidins has significantly inhibited human breast cancer, lung cancer and gastric adenocarcinoma cells in vitro. The extract did not inhibit neoplastic K562 myelogenous leukemic cells. In the same experiment, the extract enhanced growth and viability of normal human gastric mucosal cells and J774A.1 murine macrophage cells. These promising preliminary findings warrant more research.
Grape seed proanthocyanidins have been shown to significantly inhibit the peroxidation of polyunsaturated fatty acids and some other lipids in animal and in vitro studies. Some experimental data suggest that these effects might help protect capillaries, heart, brain and liver tissues in some circumstances. In one study, a grape seed proanthocyanidin extract more potently protected brain and hepatic tissues from the damage of experimentally induced reactive oxygen species damage than did other antioxidants (vitamin C, vitamin E succinate and beta-carotene). In other in vitro experiments, grape seed proanthocyanidins have strongly inhibited reactive oxygen species activities implicated in microvascular injury.
Acetaminophen-induced programmed and unprogrammed liver-cell death was dramatically prevented and reduced in mice treated with a grape seed proanthocyanidin extract. Exposure to the extract for seven days prior to acetaminophen administration was notably more effective than pre-treatment for three days. The extract significantly counteracted acetaminophen-promoted apoptotic DNA fragmentation.
In another animal model, grape seed proanthocyanidins were shown to increase resistance to myocardial ischemia reperfusion injury. And in a recent experiment utilizing cholesterol-fed rabbits, an extract of grape seed proanthocyanidins significantly attenuated the development of aortic atherosclerosis compared with controls that did not receive the extract.
- Grape Seed Extract?Muscat, Red Wine Extract,Vitis Vinefera Seed Extract?A Powerful Antioxidant and More.
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