What is icariin or Horny Goat Weed Extract?Does Horny Goat Weed and Icariin Work for Erection?How does icariin mime testosterone?

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Horny Goat Weed Research and case study.

Epimedium brevicornum herb Horny Goat Weed icariin Epimedium leaf Extract Epimedium brevicornum Maxim.Epimedium sagittatum CAS 489-32-7 photo picture image Effect of Horny Goat Weed Herbal Complex Supplement on Sexual Satisfaction in Healthy Men and Men Treated with Viagra Clinical Trial.There have been much research done on Horny Goat Weed, and its aphrodisiac effects have been well demonstrated in animals and humans.
 Purpose: We examine the effects of an herbal complex product on sexual satisfaction in healthy male volunteers and male volunteers who use Viagra.
 Methods: In this study, 25 healthy men (HM) and 13 men (VM) who used Viagra were assigned to initially receive daily therapy for 45 days with two capsules (808 mg x 2) of a commercially-prepared herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens, and polypodium vulgare . An additional four capsules (3232 mg) were taken one to two hours prior to sexual activity to determine its effect on sexual interest, sexual performance, and overall sexual satisfaction. After 45 days, the double-blind phase of the study began with a placebo product and active product randomly given to healthy men (HM) who had reported a positive response and taken for two weeks to four weeks. All subjects were evaluated after the first 45 days of treatment and finally after 60 days.
 Results: 13 of 20 HM had a positive response to the herbal mixture and 6 of the 13 VM had a positive response to the herbal mixture. In the double-blind placebo portion of the study, no HM had a positive response to placebo product; 6 of the 7 HM had a positive response to the active product.
 Conclusions: Daily use of the herbal complex for a minimum of 45 days resulted in an enhancement of sexual satisfaction in 60 percent of healthy male subjects and 45 percent of men using Viagra. The exact mechanism of action of the herbal mixture is unknown although it may have a testosterone-like effect.

 More Case Study:

 In a study done by Steven Lamm, M.D, 38 men were administered 2 capsules (2 X 800mg) of herbal complex of epimedium grandiflorum, maca pure (lepidium meyenii), mucuna pruriens,and polypodium vulgare (in short, Horny Goat Weed) for 45 days:25 were healthy men and 13 were men already taking Vi agra. Another 4 capsules of Horny Goat Weed were taken 1 to 2 hours prior to sexual activities.
 The study found 13 of 20 healthy men responded positively to Horny Goat Weed, and 6 of the 13 men already on Viagra also had a positive effect from using Horny Goat Weed. In most cases, the men reported overall improvement in sexual satisfaction and increase in sexual desires.

 Rabbit corpus cavernosum case study:

 Scientific study about the relaxation effects of icariin(C33H40O15,MW:676.67) on rabbit corpus cavernosum (CC) were investigated by in vitro study and the effects of icariin on erectile function of rats and the effects of icariin on cGMP formation and PDEs activity were investigated by in vivo study. The effects of 4 weeks oral administration of icariin (Dosage:1mg/kg/day, 5mg/kg/day) on castrated rats ED model and vasculargenic ED model were investigated too.

 icariin showed a dose dependent relaxation effects on CC of rabbit and the relaxation effects of icariin on CC were significantly inhibited by pre-treating NOS inhibitors (LNNA) and gunylate cyclase (GC) inhibitors (ODQ) by in vitro study and icariin significantly increased ICP rats without influence on MBP by in vivo study. icariin also showed specific inhibiting effect on cGMP specific PDE5 compared with other PDEs. Four weeks oral administration of icariin could enhance erectile function (ICP) of castrated and vasculargenic rats ED models with increasing NOS and isoform mRNA and protein expression in CC compared to controls.
 icariin showed selective inhibiting activity on cGMP specific PDE5 and enhancing erectile function after 4 weeks oral administration in castrated and vasculargenic ED models with regulation of NOS mRNA and protein expression in CC.

 icariin mime testosterone study.:

 To evaluate the testosterone mimetic properties of icariin.Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x day) for 5 consecutive days for groups M, ICA and T, at the sixth day, ICA (gastric gavage, 200 mg/kg x day) for the ICA group and sterandryl (subcutaneous injection, 5 mg/rat . day) for the T group for 7 consecutive days, respectively. The levels of serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), serum bone Gla-protein (BGP) and tartrate-resistant acid phosphatase activity in serum (StrACP) were determined. The histological changes of the testis and the penis were observed by microscope with hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase biotin-dUTP-X nick end labeling (TUNEL), respectively.

 Experiment above got result effectively as following expressions:
 (1) Icariin improved the condition of reproductive organs and increased the circulating levels of testosterone.
 (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. At the same time, it decreased the serum levels of StrACP and might have reduced the bone resorption.
 (3) Icarrin suppressed the extent of apoptosis of penile cavernosal smooth muscle cells.
 Conclusion was made that Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.

 Experimental study on antagonizing action of herba Epimedii on side effects induced by glucocorticoids:

 The experimental result has shown that the water extract of Herba Epimedii (Epimedium sagittalum) works very well in preventing and curing the side effects induced by long-term use of glucocorticoids in rats, especially in antagonizing adrenocortical atrophy and osteoporosis.

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citations1.What is icariin or Horny Goat Weed Extract?Does Horny Goat Weed and Icariin Work for Erection?How does icariin mime testosterone?

last edit date:30th,April.2009.