The plant is native to China, where it was long grown for its edible, starchy roots and for a fibre made from its stems. Pueraria root(kudzu root) rich of amino acid,especially contain necesarry amino acid(calculate as per 100grams dry root):lisine 10mg,Methionine 7.54mg,Phenylalanine 9.65mg,Threonine 9.63mg,leucine 11.54mg,Valine 11.24mg,Histidine 6.74mg,also contain good minerals such as selenium,zinc,manganese,germanium,etc.
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Basic Instruction
What is Pueraria root(kudzu root)?Value of Pueraria root(kudzu root) and Pueraria root(kudzu root) extracts?
Synoms in China:GeTiao(Means pieces of gegen),Fen Ge(Powder of Gegen),GanGe(mean sweet Gegen,"Gan"in pinyin means sweet in english),GeTeng(means Vine of Gegen,"Teng" means vine of a plant),LuHuo,HuangJin,JiQi,Wild Ge,etc.
Botanical Source: dry root of Pueraria lobata(Willd.)Ohwi or Pueraria.thomsonii Benth
Latin: Radix Puerariae
Plant Description:vine plant and grow reach to about 10m in length,rigid yellow brown hair grow on all herb,cross leaves shape oval,rough hair both leave sides,dense flower in blue to purple,diameter about 5 to 10 cm,flower from May to September,Fruit from August to October.
Habitat:wild field,grass land,road side,forest and moutains, mainly live in Mengo,NingXia,ShananXi,ShanXi,QingHai,HuBei,Hunan,GuangDong,Sichuan,etc.
Preparation:dig up in autumn and early winter,cut in fresh state into small pieces and make dry.
The root of Pueraria thomsanii Benth, or P. lobata Willd. The Chinese name of this herb is Gegen.
Origin:
The root of Pueraria lobata (Willd.) Ohwi or Pueraria thunbergiana, a perennial deciduous vine, of the family Leguminosae. The kudzu is a fast-growing, woody, somewhat hairy vine that may grow to a length of 18 m in one season. It has large leaves, long racemes with late-blooming reddish purple flowers, and flat, hairy seed pods.
The plant is native to China, where it was long grown for its edible, starchy roots and for a fibre made from its stems. The kudzu was transplanted to North America with the intention of using it to anchor steep banks of soil and thereby prevent erosion. The plant has become a rampant weed in parts of the southeastern United States, however, since it readily spreads over trees and shrubs as well as exposed soil.
Other uses of the kudzu vine are as a useful fodder crop for livestock, as well as an attractive ornamental. Northern winters tend to kill the plant's stems but allow the roots to survive.
The root has been used by the Chinese as an herb. In China, the plant is distributed everywhere in the south and north of China, picked and dug in spring and autumn, sliced, dried in the sun and used when raw or after it is baked.
2.Traditional Chinese Medicine Description:
Kudzu is a coarse, high-climbing, twining, trailing, perennial vine. The huge root, which can grow to the size of a human body, is the source of medicinal preparations used in traditional Chinese medicine and modern herbal products. Kudzu grows in most shaded areas in mountains, fields, along roadsides, thickets, and thin forests throughout most of China. The root of another Asian species of kudzu, Pueraria thomsonii, is also used for herbal products. Kudzu root is high in isoflavones, such as daidzein, as well as isoflavone glycosides, such as daidzin and puerarin. Depending on its growing conditions, the total isoflavone content varies from 1.77-12.0%, with puerarin in the highest concentration, followed by daidzin and daidzein. As is the case with other flavonoid-like substances, the constituents in kudzu root are associated with improved microcirculation and blood flow through the coronary arteries. A widely publicized 1993 animal study showed that both daidzin and daidzein inhibit the desire for alcohol.The authors concluded that the root extract may in fact be useful in reducing the urge for alcohol and as treatment for alcoholism. This has not yet been proven in controlled clinical studies with humans.
TCM classifies it as a sweet and pungent herb with a mild property. It is spasmolytic, antipyretic, secretory, and anti-diarrheal. It is also thought to induce the eruption of measles at the early stage.
Applications:
1. Used for exterior syndromes caused by exopathogens:
Being sweet and pungent in taste, cool in nature and so light as to be able to rise and disperse and enter the spleen and stomach channels, this herb relieves exterior syndromes by means of profuse perspiration and expels pathogenic factors from muscles and skin to reduce fever, so it is often used together with Chinese thorowax root (Radix Bupleuri), skullcap root (Radix Scutellariae), dahurian angelica root (Radix Angelicae Dahuricae), etc., e.g., Chaige Jieji Tang, for the treatment of exterior syndromes caused by exopathogens such as fever-causing stagnation of pathogenic factors, serious fever with light chills, headache with dryness of the nasal cavities, slight thirst with thin and yellow fur; often used in combination with ephedra (Herba Ephedrae), cassia twig and herbaceous peony root (Radix Paeoniae Alba), e.g., Gegen Tang, for exterior syndromes caused by pathogenic wind-cold, such as chills with anhidrosis and pains and stiffness of the nape and back.
2. Used for measles without adequate eruption:
This herb relieves exterior syndromes by dispersing exopathogens, expels pathogenic factors from muscles and skin to reduce fever and promotes eruption, so it can often be used together with skunk bugbane rhizome (Rhizoma Cimicifugae), e.g., Shengma Gegen Tang, for the treatment of initial attacks of measles, attacks of exopathogens on the superficies of the body and measles without smooth eruption; it can also be used together with peppermint, great burdock achene (Fructus Arctii), jingjie (Herba Schizonepetae), cicada slough, etc.
3. Used for thirst due to febrile disease and diabetes due to yin deficiency:
Being sweet and cool, this herb can encourage stomach-qi to rise while reducing fever, with the effect of promoting the production of body fluids to quench thirst and is often used with common reed rhizome (Rhizoma Phragmitis), Chinese trichosanthes (Radix Trichosanthis), windweed rhizome (Rhizoma Anemarrhenae), etc., for the treatment of thirst due to febrile diseases and impairment of body fluids; largely used in combination with black plums, ophiopogon root (Radix Ophiopogonis), Chinese trichosanthes (Radix Trichosanthis), dangshen (Radix Codonopsis Pilosulae), milk vetch root (Radix Astragali seu Hedysari), etc., e.g., Yu Chuan Wan, for the treatment of diabetes due to internal heat.
4. Used for diarrhea or dysentery due to pathogenic heat and diarrhea due to deficiency of the spleen:
This herb can not only clear away and disperse pathogenic heat, but also raise lucid yang in such a way as to encourage the clear yang-qi of the spleen and stomach to rise and achieve the effect of relieving diarrhea or dysentery, so it is often used together with skullcap root (Radix Scutellariae), Chinese goldthread rhizome (Rhizoma Coptidis) and licorice, e.g., Gegen Qin Lian Tang for the treatment of dysentery due to pathogenic heat with undispersed exterior syndromes and the invasion of pathogenic heat into the interior; often used in combination with ginseng, tuckahoe (Poria cocos), licorice, etc., e.g., Qiwei Baishu San, for diarrhea due to deficiency of the spleen.
Nutritional Value::
Pueraria root(kudzu root) rich of amino acid,especially contain necesarry amino acid(calculate as per 100grams dry root):lisine 10mg,Methionine 7.54mg,Phenylalanine 9.65mg,Threonine 9.63mg,leucine 11.54mg,Valine 11.24mg,Histidine 6.74mg,also contain good minerals such as selenium,zinc,manganese,germanium,etc.
kudzu vine,kudzu leaves:
kudzu vine(pueraria vine) and kudzu leaves(pueraria leaves) contain dry phyto protein no less than 16.5% to 22.5%,and the output of kudzu vine(pueraria vine) and kudzu leaves(pueraria leaves) is more higher than other bird's foot(legumina pasture),fit for feed bird and livestock,wild kudzu plant grow in rich state and have good patience for bad weather,dry weather,still be viridity in 2 months without any rain.
kudzu flower(pueraria flower):
kudzu flower(pueraria flower),pick up in autumn,dry in the sun,best material for kudzu tea,and good for cure alcoholic flash,bad appetite,vomit and spit acid,hematemesis,and other disease.kudzu flower(pueraria flower) rich of phyto protein,plant fat,carbohydrate,mineral,vitamins and other nutrients.kudzu flower(pueraria flower) also fit for cooked and taste fresh,good for treat bad appetite,indigestion,etc.
kudzu worm:kudzu worm is a kind of easy rider live on kudzu plant,and this kind of worm also could be used for cure bad appetite,indigestion,etc.
Main Content:Puerarin[3681-99-0]
Formula: C21 H20O9. Molecular Weight:115.1316
CAS RN:3681-99-0 Melting Point:228 - 233
Major Constituents Used:Puerarin ,Daidzein, Daidzin, Genistein, Genistin, Glycitein, Glycitin
4.Pharmacology:
A.Coronary and Cerebral Vasodilatory Effects:
The decoction or ethanol extract of Gegen (which contains total flavones, daidzin, and Puerarin) upon being administered to rats intraperitoneally or subcutaneously antagonized acute myocardial ischemia induced by pituitrin. The injection of Puerarin caused a marked increase in the coronary flow and a decrease in vascular resistance. During intravenous injection, the blood flow of the internal carotid and femoral arteries was also increased, though not as markedly as that in the coronary vessels. The inability of reserpine to modify the action of the total flavones and Puerarin on coronary circulation indicates a direct relaxant action on the vascular smooth muscle. Puerarin was more potent than the total flavones. Intravenous injection of Puerarin in anesthetized dogs decreased the heart rate and the total peripheral resistance, slightly decreased the left ventricular work, reduced the myocardial oxygen consumption, and increased the myocardial efficiency. The cardiac output, however, was not significantly altered. These effects were beneficial to the maintenance of equilibrium between myocardial oxygen demand and supply [3]. IV injection of extract of Gegen in anesthetized dogs with acute myocardial infarction induced by ligation of the anterior descending coronary artery caused a significant decrease in blood pressure, a slowing of the heart beat, and a slight decrease in blood flow in the infarcted area. At the same time, it caused no significant change in the arterial blood oxygen, but significant increase in the venous blood oxygen at the coronary sinus and infracted area. The oxygen utilization and consumption, as well as lactic acid content, in both the normal and infarcted areas were markedly decreased. Whereas lactic acid utilization was markedly increased. These results indicate that Puerarin has excellent effects on the metabolism of infarcted myocardium. Injection of total flavones to the internal carotid artery of anesthetized dogs causes a dose-dependent increase in the cerebral blood flow and a decrease in cerebral vascular resistance.
B.Hypotensive Effects:
Pueraria's total flavones can causes hypertensive dogs and normotensive anesthetized dogs to lower their blood pressure. In hypertensive dogs, the pressure response to norepinephrine and the hypotensive effect of acetylcholine could be attenuated by the ethanol extract of Gegen. It has a direct vasodilatory action, which decreases the peripheral vascular resistance. It can also decrease the blood catecholamine level and vascular reactivity. This may be the reason why it can be effectively used for treating migraine headaches.
C.Inhibition of Platelet Aggregation:
ADP-induced rat platelet aggregation was inhibited to different extents by 0.25, 0.5, and 1.0 mg/ml of Puerarin in vitro, and also intravenous injection. At doses of 0.5 ¨C 3.0mg/ml, Puerarin also inhibited (in vitro) aggregation of rabbit and sheep platelets, and those of normal subjects induced by ADP or serotonin. It can also inhibit secretion of serotonin from platelets. This effect is favorable to the prevention and treatment of angina pectoris and myocardial infarction.
D.b-Adrenergic Blocking Effect:
In various isolated tissues with Beta-Adrenergic receptors, this herbal extract exhibited different degrees of significant antagonism against the effect of isoproterenol. This fact suggested that it is a wide-spectrum beta-blocker. The extract of Gegen at doses as low as 15 mg markedly attenuated the stimulant effect of 5 ug of isoproterenol on the isolated heart. Whereas tenfold the above dose had practically no direct inhibitory effect on normal hearts, nor does it influence the cardiotontic effect of digitalis glycosides. The findings suggest that the herb has selectivity to the ¦Â1-receptors. The beta2-receptor blocking action was found to be weak because doses up to 150 mg were required in order to antagonize bronchodilation and peripheral vasodilation induced by isoproterenol.
5.Pharmacokinetics:
Orally administered Puerarin was rapidly but incompletely absorbed in rats. IV injection of this substance was found highest in concentration in the kidney, lower in plasma, liver, and spleen, and lowest in the brain. It was minimally destroyed in the gastrointestinal tract, and it was metabolized in the blood, liver, and kidneys. Also, it can bind to the proteins of liver, kidneys, lungs and plasma. The 24-hour urinary and fecal excretion of the oral dose of Puerarin accounted for 1.85 and 35.7% respectively. The data showed that after administered, it was rapidly distributed and eliminated, with low accumulation.
Properties: Pungent and sweet in flavor, cool in nature, it is related to the spleen and stomach channels.
Functions: Expels pathogenic factors from muscles and skin to reduce fever, promotes eruption, promotes the production of body fluids to quench thirst and invigorates the vital functions to relieve diarrhea.
It is spasmolytic, antipyretic, secretory, and anti-diarrheal. It is also thought to induce the eruption of measles at the early stage;
The herb is used in China to treat fever, headache, stiffness of back and neck, dry mouth in diarrhea or dysentery, and early-stage measles.
Treats angiocardiopathy. A scavenger of reactive oxygen species and inhibitor of LDL oxidation. It has potential effect to prevent atherosclerosis
Oral administration of dried ethanol extract (10,000 to 20,000 mg/kg daily for three days) to mice did not result in any toxic effects. Likewise, no toxic effects were exhibited by the total flavones. The LD50 of the dried ethanol extract in mice was 2000-2120 mg/kg. Oral administration of the ethanol extract (2,000 mg/kg daily) to mice for two months did not cause pathological changes in the solid organs. Likewise, administration of the ethanol extract to hypertensive dogs (2,000 mg/kg daily for 14 days) orally produced no toxic effects either.
Safety and Acute toxicity:Puerarin
CAS No.:3681-99-0.Molecular Formula:C21-H20-O9. Molecular Weight:416.41
Synonmys:4H-1-Benzopyran-4-one;8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-
Acute toxicity(LD50):Puerarin
LD50-Lethal dose,50 percent kill. Intravenous.Rodent-mouse. 738mg/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:CYLPDN Zhongguo Yaoli Xuebao.Acta Pharmacologica Sinica.Chinese Hournal of Pharmacology.(China International Book Trading Corp.,POB 2820,Beijing,Peop.Rep.China)V.1-1980-Volume(issue)/page/year:6,166,1985
7.Clinical Studies:
A.Headache and Migraine:
Symptomatic improvement was achieved in 35 of 42 migraine cases. In hypertensive patients, it improved the cerebral blood flow, lowered the vascular resistance, and shortened the influx time in about 50% of the cases.
B.Hypertension:
The total flavones (100 mg daily in two doses) was given for a course of 2-8 weeks to 222 cases of hypertension with pain and stiffness of the neck. 78-90% of the cases reported relief of neck symptoms. In 90% of the cases remedial effects appeared after one week of administration, persisting for one to two weeks. In some patients there were no relapses during a period of 3 to 9 months after discontinuation of therapy. The treatment alleviated symptoms of headache, dizziness, tinnitus, and numbness of extremities but did not significantly lower the blood pressure.
C.Coronary Disease and Angina Pectoris:
191 cases of coronary disease and angina pectoris were treated with Gegen tablet (each tablet contains 10 mg of total flavones), 3-4 tablets three times a day. This treatment was effective in relief of anginal pain and in improving ECG. Another group of 110 cases of coronary disease were treated with a compound of extract of Puerarin and Crataegi, 90% of them had relief of anginal pain and 43% had marked improvement.
D.Sudden Deafness at Early Stage:
The tablets of the ethanol extract of Gegen (each equivalent to 1.5 grams of crude herb) were used at dose of 1-2 tablets three times a day together with injection of the total flavones 100 mg IM twice daily (and in some cases also supplemented with vitamin B complex) in order to treat 176 cases for a course of one to two months, hearing improvement in 79.5% of the cases.
8.Kudzu Root Modern Researches:
This herb mainly contains flavones, such as daidzein, daidzin, daidzein-4, 7-diglucose glucoside, puerarin, puerarin-7-xyloside, puerarol, xylopuerarin, isoflavonoid glycoside and starch. Kudzu vine root can dilate coronary vessels and cerebral blood vessels and increase the blood flow of coronary arteries.
Total flavone of kudzu vine root can reduce the myocardial oxygen consumption and increase the supply of oxygen. Kudzu vine root can directly dilate the blood vessels to lower peripheral resistance. It can also reduce blood pressure remarkably and alleviate the "nape tension" symptom of a patient with a high blood pressure in a better way. Puerarin can inhibit the platelet aggregation. Kudzu vine root has an extensive blocking effect on beta-receptors. Kudzu vine root also has an obvious antipyretic effect and can also reduce blood sugar slightly.
Updates:
1.Determination of 12 pueraria components by high-performance liquid chromatography-mass spectrometry:
Puerariae radix, a commonly used Chinese herb drug derived from the dried root of legume plant, contains a series of isoflavones as its chief pharmacologically active constituents. Using 12 pueraria components as markers, an LC-UV-MS method requiring less than 60 min, was developed for estimating the quality of pueraria samples within 60 min. Extracts were analyzed using a Cosmosil 5C18-MS column, by gradient elution with an aqueous solution of acetic acid and methanol-ACN at a flow-rate of 1.0 mL/min. Peaks were detected at 254 nm and each peak was identified by LC/MS. The reproducibilities (RSD) of this proposed method, on the basis of peak-area ratios from six replicate injections, were 0.93-1.42% (intraday) and 1.05-1.63% (interday) at a detection limit of 0.12-0.78 microg/mL. Most of the markers used in this study can be classified, respectively, into three major categories, namely, isoflavones, O-glycosidic isoflavones, and C-glycosidic isoflavones. The structures of the compounds were determined from LC-MS fragmentation data and data from the literature.
2.An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting:
Background: Of the available medications for treating alcohol-related problems, none are universally effective, and all have side effects that may limit their use. Extracts of kudzu containing a variety of isoflavones have been shown to reduce alcohol drinking in rats and hamsters.
Methods: The present study was designed to test the efficacy of a kudzu extract in a clinical population. Male and female "heavy" alcohol drinkers were treated with either placebo or a kudzu extract for 7 days and then given an opportunity to drink their preferred brand of beer while in a naturalistic laboratory setting. Participants served as their own controls, and order of treatment exposure was counterbalanced. Drinking behavior was monitored by a digital scale that was located in the top of an end table.
Results: Kudzu treatment resulted in significant reduction in the number of beers consumed that was paralleled by an increase in the number of sips and the time to consume each beer and a decrease in the volume of each sip. These changes occurred in the absence of a significant effect on the urge to drink alcohol. There were no reported side effects of kudzu treatment.
Conclusion: These data suggest that an extract of this leguminous plant may be a useful adjunct in reducing alcohol intake in a naturalistic setting.
3.Combination Case Study:Breast Pretty Precious
There are many combination with pueraria root aim at breast beauty with other herbs, a product named Breast Pretty Precious exampled as given below:Combined with herbs pawpaw fruit,Pueraria root,Wild Yam,Logan,Chinese Date,Wolfberry fruit,Tomato,Semen Coicis,Grapeseed,Soy milk,Vitamin B6,Vitamin B12,Vitamin E,etc and lactose as additives.
Suggest taken 5grams twice daily, before breakfast and night dreams. It is said to make girl breast enlarged from D to G size.
9.How Search engine think about kudzu:
kudzu is king ~ april 27
kudzu is king
kudzu is oblivious to both chemicals and pests
kudzu is green
kudzu is so plentiful that it was ignored by americans as a wild food until about twenty years ago
kudzu is also a valuable natural medicine
kudzu is a non
kudzu is planted during daylight hours
kudzu is used in ways which might surprise you
kudzu is cooked as food in china
kudzu is in texas and doing very well
kudzu is fast
kudzu is right up there with death and taxes
kudzu is planted around porches throughout the south for it?s fragrant flowers
kudzu is a vine that when left uncontrolled will eventually grow over almost any fixed object in its proximity including other vegetation
kudzu is on dawson forest rd
kudzu is minimal
kudzu is the super vine of the southeastern united states
kudzu is well adapted to the southern united states; in northern regions
kudzu is a long sustaining source of energy in an
kudzu is a rather interesting specialty she took on for herself
kudzu is a climbing or trailing
kudzu is present in a diet
kudzu is abundant throughout the southeastern united states from texas to virginia and southward
kudzu is a vine native to China which was introduced to the southeastern
kudzu is a fast growing
kudzu is a deciduous twining vine that spreads rapidly and covers everything in its path with a dense tangle of hairy stems and large trifoliate
kudzu is an incredibly aggressive
kudzu is perhaps the largest nonwoody weed problem in forest management in the south
kudzu is a perennial
kudzu is difficult to eliminate with herbicides and requires repeated annual control efforts to keep it in check and from spreading to new areas
kudzu is an unstoppable vine that we have here
kudzu is gegen
kudzu is a vine that loses its leaves in the fall
kudzu is a blessing from god
kudzu is a chinese vine introduced for decorative reasons to the us in 1876
kudzu is respected and enjoyed there
kudzu is the south defining product
kudzu is lively
kudzu is certainly not the most popular plant in the southern us
kudzu is common in alabama
kudzu is common throughout most of the southeastern us and has been found as far north as pennsylvania
kudzu is an annoying little plant that can be easily killed by the weakest exile
kudzu is an awesome beast
kudzu is a weedy vine
kudzu is the red hat linux hardware probing library
kudzu is an extraordinary vining ornamental plant with large green leaves
kudzu is that they give up too easily
kudzu is good
kudzu is not discarded; instead
kudzu is a surprisingly frugal seed producer
kudzu is edible
kudzu is deciduous
kudzu is in bloom
kudzu is aserl's shared catalog
kudzu is an extremely fast growing weed
kudzu is a fast
kudzu is now a classic image of the south
kudzu is not prohibited
kudzu is not actually a
kudzu is really good for them
kudzu is?
kudzu is the deep
kudzu is not found in grazed pastures
kudzu is one of the most common and troublesome weeds of rights
kudzu is that leafy vine that you often see growing up telephone poles or
kudzu is a climbing or trailing perennial native to eastern asia
kudzu is under control now
kudzu is also used for allergies
kudzu is proud to announce that it is holding summer camp and family retreat programming for our state
kudzu is
kudzu is a serious noxious weed that has plagued the southeastern united states for decades
kudzu is a type of legume
kudzu is found in china
kudzu is now entrenched and as much a part of the landscape as dogwoods and azaleas
kudzu is a leafy vine that was introduced to the southeast in the 1930's to prevent soil erosion
kudzu is georgia only sleep
kudzu is a hardy
kudzu is an invasive plant that has been called the vine that swallowed the south
kudzu is an extremely aggressive plant and in most places considered a pest; however
kudzu is a substantial change over last season's car
kudzu is the
kudzu is a coarse
4.Antitumor activity of spinasterol isolated from Pueraria roots.:
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenating folk medicine in Thailand and China. Dried, powdered plant material was extracted with 100% ethanol and further separated by concentration, filtration, and thin layer silica gel chromatography. Using the fractions obtained during separation, we first investigated their cytotoxicity in several cancer cell lines from various tissues. The ethanol-extracted components (PE1, PE4) had significant antiproliferative effects on breast cancer cell lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. Second, we compared these results with the cytotoxic effects of known flavonoids, sterols, and coumarins from Pueraria root. The known compounds were not as effective, and occurred in a different polarity region on HPLC. Third, further separation resulted in the isolation of eight different components (Sub PE-A to -H). One of these, PE-D, affected the growth of some breast cancer cell lines (MCF-7, MDA- MB-231) in a dose- and time-dependent manner, as well as the growth of ovarian (2774) and cervical cancer cells (HeLa). Finally, a transfection assay showed that this component had an estrogenic effect similar to 17beta - estradiol, which activates both estrogen receptor alpha (ERalpha) and ERbeta. The NMR analysis determined that spinasterol (stigmasta-7, 22-dien-3beta-ol) is an active cytotoxic component of Pueraria root.
5.Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography.:
The estrogenic activity of the Chinese herb kudzu root was investigated by a recombinant yeast screening assay (YES). Isoflavones are the main components in the plant, of which puerarin is the most abundant one. The kudzu root extract was separated into four fractions according to the polarity. The crude extract and its sub-fractions, except the water fraction, showed clear estrogenic activity and the potencies were in the range of 10(-3) to 10(-1)g/l. The ligand potency was used to compare the estrogenic activity of these fractions. The crude extract and its sub-fractions were further analyzed by high performance liquid chromatography (HPLC) to correlate the activity and the active components. Bioassay and chemical analysis showed that theoretical estrogenic activity expressed as equivalent 17beta-estradiol concentration or the cumulative effects are comparable to that experimentally determined by YES. The results showed that the high content of isoflavones as well as the high estrogenic activity could make kudzu root extract an interesting candidate for hormone replacement therapy.
6.Quantitative analysis of phytoestrogens in kudzu-root, soy and spiked serum samples by high-pressure liquid chromatography.:
A sensitive and reliable HPLC method that allows simultaneous quantification of phytoestrogens extracted from kudzu-root and soy preparations, and serum samples has been developed. Kudzu-root and soy preparations were mixed with 5 microg flavone and 15 microg rutin (internal standards) and the phytoestrogens were extracted by using solid-phase (C18) extraction cartridges. Blank or spiked serum samples were extracted by using either C18 cartridges or trichloroacetic acid-methanol extraction. The extracts were analyzed by the HPLC equipped with a reverse-phase (250 x 4 mm, C18) column and UV, diode-array or MS detector. A linear gradient of acetic acid and acetonitrile provided excellent separation of glycoside and aglycone-phytoestrogens from kudzu root and soy preparations. The C18 cartridge extraction of serum yielded excellent recovery of both glycoside- and aglycone-phytoestrogens, while the trichloroacetic acid-methanol extraction yielded excellent recovery of glycoside but poor recovery of aglycone compounds. UV and MS detectors were suitable for phytoestrogen analysis in plant and serum samples, while the diode-array detector was suitable for generating the UV absorbance curve for phytoestrogens.
Scientific References:
What is Pueraria root.kudzu root and Pueraria root extract?
Claims & Warning:
Claims: Information this web site presented is meant for Nutritional Benefit and as an educational starting point only, for use in maintenance and promotion good health in cooperation with a common knowledge base reference...Furthermore,it based solely on the traditional and historic use or legend of a given herb from the garden of Adonis. Although every effort has been made to ensure its accurate, please note that some info may be outdated by more recent scientific developments......
Pharmakon Warning: The order of knowledge is not the transparent order of forms and ideas,as one might be tempted retrospectively to interpret it; it is the antidote....(Dissemination,Plato's Pharmacy,II.The Ingredients:Phantasms,Festivals,and Paints;138cf. Jacques Derrida.).
And as it happens,the technique of imitation,along with the production of the simulacrum,has always been in Plato's eyes manifestly magical,thaumaturgical:......and the same things appear bent and straight to those who view them in water and out,or concave and convex,owing to similar errors of vision about colors, and there is obviously every confusion of this sort in our souls.And so scene painting (skiagraphia) in its exploitation of this weakness of four nature falls nothing short of witchcraft (thaumatopoia), and so do jugglery and many other such contrivances.(Republic X,602c-d;cf.also 607c).
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MDidea Extracts Professional
Standard Herbal Extract Series:
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Serie No.:S026.Basic Data Sheet Download
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seminal trace...Pueraria root Extract.Puerarin 97%98%,99%HPLC.Pueraria Flavones,Isoflavones 40%,60%UV.HPLC.CAS.NO:3681-99-0;.M.F.:C21H20O9;Pueraria lobata root extract.Kudzu root extract...Pueraria thunbergiana extract.CAS.NO:000000-10-8.Kudzu Vine extract.Pueraria thunbergiana. Benth.Pueraria thomsoniu Benth......
Origin:
1. Used for exterior syndromes caused by exopathogens:
Scientific References:
Claims & Warning:
