What is Pueraria root kudzu root?Value of Pueraria root kudzu root and Pueraria root kudzu root extracts?

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Pharmacology.

Pueraria root Extract Pueraria Lobata Extract CAS 223748-08-1 photo picture image

 A.Coronary and Cerebral Vasodilatory Effects:

 The decoction or ethanol extract of Gegen (which contains total flavones, daidzin, and Puerarin) upon being administered to rats intraperitoneally or subcutaneously antagonized acute myocardial ischemia induced by pituitrin. The injection of Puerarin caused a marked increase in the coronary flow and a decrease in vascular resistance. During intravenous injection, the blood flow of the internal carotid and femoral arteries was also increased, though not as markedly as that in the coronary vessels. The inability of reserpine to modify the action of the total flavones and Puerarin on coronary circulation indicates a direct relaxant action on the vascular smooth muscle. Puerarin was more potent than the total flavones. Intravenous injection of Puerarin in anesthetized dogs decreased the heart rate and the total peripheral resistance, slightly decreased the left ventricular work, reduced the myocardial oxygen consumption, and increased the myocardial efficiency. The cardiac output, however, was not significantly altered. These effects were beneficial to the maintenance of equilibrium between myocardial oxygen demand and supply [3]. IV injection of extract of Gegen in anesthetized dogs with acute myocardial infarction induced by ligation of the anterior descending coronary artery caused a significant decrease in blood pressure, a slowing of the heart beat, and a slight decrease in blood flow in the infarcted area. At the same time, it caused no significant change in the arterial blood oxygen, but significant increase in the venous blood oxygen at the coronary sinus and infracted area. The oxygen utilization and consumption, as well as lactic acid content, in both the normal and infarcted areas were markedly decreased. Whereas lactic acid utilization was markedly increased. These results indicate that Puerarin has excellent effects on the metabolism of infarcted myocardium. Injection of total flavones to the internal carotid artery of anesthetized dogs causes a dose-dependent increase in the cerebral blood flow and a decrease in cerebral vascular resistance.
 Pueraria root Extract Pueraria Lobata Extract CAS 223748-08-1 photo picture image

 B.Hypotensive Effects:

 Pueraria's total flavones can causes hypertensive dogs and normotensive anesthetized dogs to lower their blood pressure. In hypertensive dogs, the pressure response to norepinephrine and the hypotensive effect of acetylcholine could be attenuated by the ethanol extract of Gegen. It has a direct vasodilatory action, which decreases the peripheral vascular resistance. It can also decrease the blood catecholamine level and vascular reactivity. This may be the reason why it can be effectively used for treating migraine headaches.

 C.Inhibition of Platelet Aggregation:

 ADP-induced rat platelet aggregation was inhibited to different extents by 0.25, 0.5, and 1.0 mg/ml of Puerarin in vitro, and also intravenous injection. At doses of 0.5 ~ 3.0mg/ml, Puerarin also inhibited (in vitro) aggregation of rabbit and sheep platelets, and those of normal subjects induced by ADP or serotonin. It can also inhibit secretion of serotonin from platelets. This effect is favorable to the prevention and treatment of angina pectoris and myocardial infarction.

 D.b-Adrenergic Blocking Effect:

 In various isolated tissues with Beta-Adrenergic receptors, this herbal extract exhibited different degrees of significant antagonism against the effect of isoproterenol. This fact suggested that it is a wide spectrum beta blocker. The extract of Gegen at doses as low as 15 mg markedly attenuated the stimulant effect of 5 ug of isoproterenol on the isolated heart. Whereas tenfold the above dose had practically no direct inhibitory effect on normal hearts, nor does it influence the cardiotontic effect of digitalis glycosides. The findings suggest that the herb has selectivity to the beta1-receptors. The beta2-receptor blocking action was found to be weak because doses up to 150 mg were required in order to antagonize bronchodilation and peripheral vasodilation induced by isoproterenol.

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citations1.What is Pueraria root kudzu root?Value of Pueraria root kudzu root and Pueraria root kudzu root extracts?

last edit date:5th,May.2009.