What is Marigold Flower Petals Extract? What is Lutein?Application and Value of Lutein as super remedy?

Lutein:Safety and recommendation.

Marigold Flower Extract.Lutein TAGETES ERECTA EXTRACT EINECS ELINCS 290-353-9 CAS:90131-43-4 Calendula officinalis,Marigold Extract.Tagetes erecta extract,Tagetes erecta flower extract photo picture image Safety and Acute Toxicity:Calendula Extract.

Calendula Aqueous Extract:LD50.Lethal dose,50 percent kill.Intravenous.rodent-mice.375 mg/kg.
Calendula Aqueous Extract:LD100.Lethal dose,100 percent kill.Intraperitoneal.rodent-mice.580 mg/kg.
Calendula Aqueous Ethanolic Extract (drug/extract ratio 1 : 1 and 0.5 : 1, 30% ethanol):LD50.Lethal dose,50 percent kill.Subcutaneous.rodent-rat.526 mg/100 g

An aqueous extract of calendula had an LD50 of 375 mg/kg (intravenous administration) and an LD100 of 580 mg/kg (intraperitoneal administration) in mice.
Aqueous ethanolic extracts (drug/extract ratio 1 : 1 and 0.5 : 1, 30% ethanol) had LD50 values of 45 mg/mouse (subcutaneous administration) and 526 mg/100 grams in rat (intravenous administration).
An aqueous extract was not toxic following chronic administration to mice. Six saponins at doses of 400 micrograms were non-mutagenic in the Ames test using Salmonella typhimurium TA98 with and without S9 activation mixture.
In vitro cytotoxicity has been reported for calendula extracts.Extracts have been reported to be non-carcinogenic in rats and hamsters.
Reference:Boucard-Maitre Y et al. Cytotoxic and antitumoral activity of Calendula officinalis extracts. Pharmazie 1988; 43: 220.(PubMed)

Subchronic toxicity:Lutein

Subchronic toxicity.NOAEL.Oral.Rat.>350 mg/kg.
Subchronic toxicity.NOAEL.Oral.Dog.>150 mg/kg.
ADI(acceptable daily intake).2 mg/kg body weight(equivalent to 120 mg/day for a 60 kg person).

There is a long history of safe consumption of lutein containing fruits and vegetables in humans.A lutein formulation based on free lutein derived from Tagetes erecta was tested in toxicological studies to determine safety.This lutein formulation was not mutagenic and did not show genotoxicity in vivo.Repeated dose oral toxicity was tested in rats and dogs and it was demonstrated that the lutein formulation did not show any sign of subchronic toxicity with a NOAEL of greater than 350 mg lutein/kg body weight per day in rats and a NOAEL of greater than 150 mg lutein/kg body weight per day in dogs.In addition,the lutein formulation did not show any signs of maternal and developmental toxicity in doses up to 200 mg lutein/kg body weight per day.

Based on a high safety margin,BASF recommends an intake of up to 15 mg lutein per day.No RDA for lutein has been established in any country to date.However,the JECFA(Joint FAO/WHO Expert Committee on Food Additives) extrapolated animal data to set an ADI(acceptable daily intake) of 2 mg/kg body weight(equivalent to 120 mg/day for a 60 kg person) for lutein and zeaxanthin derived from Tagetes erecta.

Lutein supplements may serve as a beneficial adjunct to food intake and may provide a considerable health benefit for the public.Lutein 5% DC contains free lutein derived from marigold flowers (Tagetes erecta).

Dosage and Suggestions:

Dried Florets: 1-4 g or by infusion three times daily.
Liquid Extract: 0.5-1.0 mL (1 : 1 in 40% alcohol) three times daily.
Calendula Tincture: (BPC 1934) 0.3-1.2 mL (1 : 5 in 90% alcohol) three times daily.
Dried Extract: Marigold (Calendula) capsules are generally available in strengths that range from 300 to 600 mg. Within herbal blends, quantities of marigold flower are significantly smaller. Typically, a capsule strength of 400 to 500 mg is recommended to be taken 3 times daily.
External Use Tincture-liquid extract (1 : 1) in 40% alcohol or tincture 1 : 5 in 90% alcohol. Apply to wounds as such and dilute 1 : 3 with water for compresses. Ointment 2.5%.

The German Commission E Monographs recommend the following dosages for liquid preparations / infusions:1-2 g per cup of water (150 mL) or 1-2 teaspoons (2-4 mL) tincture per 1/4-1/2 L water, or prepared in ointments equivalent to 2-5 g crude drug in 100 g ointment.

Guidelines For Specific Indications:
For burns (including sunburn), apply three times a day to affected area until healed.
For athletes foot, apply cream or lotion to affected area twice a day until clear.
For insect bites and stings, rub a small dab of cream into skin several times a day or as needed.
For canker sores, rinse mouth 1 tbsp. liquid extract mixed with 1/2 cup water or with cooled tea 3 times a day.
For cuts and scrapes, apply ointment or cream 3 times a day, bandaging lightly if necessary.

Precautions Contraindications:

Calendula may cause an allergic reaction in sensitive individuals, especially those with an existing hypersensitivity to other members of the Asteraceae/Compositae.

Pregnancy and Lactation:

Calendula is traditionally reputed to affect the menstrual cycle. An uterotonic effect (in vitro) has been reported, and the triterpenoid constituents are reported to be effective as spermatocides and as antiblastocyst and abortion agents. In view of the lack of toxicity data, the use of calendula is best avoided during pregnancy and lactation.
When treating any type of wound, remember that the most important thing you can do to prevent infection is to thoroughly clean the area before applying calendula ointment or any other type of herb or medicine.

Pharmacological Summary:

Phytochemical studies have reported four main groups of constituents, for calendula, namely flavonoids, polysaccharides, volatile oil and triterpenes. The latter seems to represent the principal group, with many compounds isolated including pentacyclic alcohols, glycosides (saponins) and sterols. Animal studies have reported wound-healing and anti-inflammatory effects, supporting the traditional uses of calendula in various dermatological conditions. The anti-inflammatory effect is due to the triterpenoid constituents although flavonoids may contribute to the activity. The reputed antispasmodic effect may be attributable to the volatile oil fraction. In addition, immunostimulant activity has been reported for high mol ecular weight polysaccharide components. Despite the popularity of calendula in herbal preparations there is little substantial clinical evidence to support its use.

Reference:

1.What is Marigold Flower Petals Extract? What is Lutein?Application and Value of Lutein as super remedy?

last edit date:25th,Feb.2010.

Available Product

Name:Marigold Flower Extract.Lutein
Serie No:S-016.
Specifications:Lutein 5%,10%,20%,50%UV.
INCI Name:TAGETES ERECTA EXTRACT
EINECS/ELINCS No.:290-353-9
CAS:90131-43-4
Chem/IUPAC Name:Tagetes Erecta Extract is an extract of the flowers aztec marigold,Compositae

Supplying Conditions