Pine Bark Extract Proanthocyanidins and Pine Bark logogriph.Pine Bark Extract.

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Physiology and Historical Uses.

Pine Bark Extract INCI Name Pinetree extract CAS 000000-14-0 French Marine Pine Bark Extract French Maritime Pine Bark Extract Leucoanthocyanidins OPC Oligomeric Proanthocyanidins PCO Pinus maritima Pinus pinaster Procyandiol Oligomers Procyanodolic Oligomers Pycnogenol Pygenol Pine Bark Extract.Proanthocyanidins Pinus Strobus Bark extract.Proanthocyanidin B2 photo picture image Physiology:

 Free radicals do damage in the capillaries in two ways: (1) by inactivating a compound called a 1-antitripsin, whose role is to restrain the enzymes that break down collagen, elastin and hyaluronic acid, and (2) by turning the fats in the cell membranes rancid (lipid peroxidation).

 Proanthocyanidins protect both the 1-antitripsin and the lipids by neutralizing the specific types of free radicals most likely to damage them, and may also directly inhibit the damaging enzymes. Collagen, elastin and hyaluronic acid make up much of the inner wall and supporting matrix of the capillaries; when they are in good shape the capillaries stretch to let red blood cells through the tight places and do not let the fluids in the blood leak out.

 Pro-anthocyanidins have shown a marked tendency to accumulate in tissues with high contents of glycosaminoglycans (complex amino sugars), such as capillary walls and skin. This may also apply to cartilage and synovial fluid. Proanthocyanidins have also shown antimutagenic effects in vitro at high concentrations (250 mcg/ml).

 Historical Uses:

 Pine Bark extract is used for its free radical fighting capabilities, and for a variety of conditions related to capillary health and permeability. It is synergistic with vitamin C which is more potent and absorbed more rapidly when used together with Proanthocyanidins. Proanthocyanidins have been indicated for:

 poor distribution of microcirculatory blood flow in the brain and heart;
 altered capillary fragility and permeability (in diabetes mellitus);
 chronic arterial/venous insufficiency in the extremeties;
 altered platelet aggregation and other characteristics of blood flow in capillaries;
 breakdown in the elastic fibers of the capillaries (collagen and elastin) due to free radical and enzyme action;
 microangiopathy of the retina, edema of the lymph nodes, varicose veins and other symptoms of the problems listed above;
 the cumulative effects of aging and reducing the risk of degenerative diseases.

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citations1.Pine Bark Extract Proanthocyanidins and Pine Bark logogriph.Pine Bark Extract.

last edit date:11th,May.2009.