What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.

Contents

• What is Transresveratrol:Basic Botanical Data and Product Data of Transresveratrol.
• What is Polygonum cuspidatum?Is Polygonum cuspidatum same as Reynoutria japonica?
• Analysis Method,differentiation of MDidea Transresveratrol.
• High-speed counter-current chromatography separation and purification of resveratrol and piceid.
• Narrative History and Origin of Resveratrol.
• Phytochemicals of Polygonum cuspidatum.
• Health Benefits and research of transreveratrol.
• Reveratrol Biological Activities.
• Anti-platelet effects of trans-resveratrol from Polygonum cuspidatum Extract.
• Anti-HIV Effects of transresveratrol.
• Research Update:Protective effects of polydatin against CCl4-induced injury to primarily cultured rat hepatocytes.
• The chemistry and biosynthesis of resveratrol.
• Cosmetic compositions containing resveratrol and retinoids.
• Polygonum Caspidatum and treatment of viral myocarditis:Coxsackie Virus Infections
• SARS and Polygonum Caspidatum new use.
• Polygonum Caspidatum and West Nile virus treatment.
• Reveratrol and Cardiovascular Disease Prevention.
• Reveratrol Safety and Administration.
• Research update of Polygonum Cuspidatum Extract.Resveratrol.
• Photo Gallery of Polygonum Cuspidatum.

Reveratrol Biological Activities.

Direct Antioxidant Activity of Reveratrol.

 In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation. However, there is little evidence that resveratrol is an important antioxidant in vivo. After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol.

 Estrogenic and Anti-estrogenic Activities of Reveratrol:

 Endogenous estrogens are steroid hormones synthesized by humans and other mammals that bind to estrogen receptors within cells. The estrogen-receptor complex interacts with unique sequences in DNA to modulate the expression of estrogen-responsive genes. A compound that binds to estrogen receptors and elicits similar responses to endogenous estrogens is considered an estrogen agonist, while a compound that binds estrogen receptors but prevents or inhibits the response elicited by endogenous estrogens is considered an estrogen antagonist. The chemical structure of resveratrol is very similar to that of the synthetic estrogen agonist, diethylstilbestrol, suggesting that resveratrol might also function as an estrogen agonist. However, in cell culture experiments resveratrol acts as an estrogen agonist under some conditions, and an estrogen antagonist under other conditions.

 In estrogen receptor-positive breast cancer cells, resveratrol acted as an estrogen agonist in the absence of the endogenous estrogen, 17-beta-estradiol, but acted as an estrogen antagonist in the presence of 17-beta-estradiol. At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens.
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 Cancer Prevention:Effects on Biotransformation Enzymes:

 Some compounds are not carcinogenic until they have been metabolized in the body by cytochrome P450 enzymes. By inhibiting the expression and activity of certain cytochrome P450 enzymes, resveratrol could help prevent cancer by decreasing exposure to these activated carcinogens. In contrast, increasing the activity of phase II biotransformation enzymes generally promotes the excretion of potentially toxic or carcinogenic chemicals. Resveratrol has been found to increase the expression and activity of the phase II enzyme NAD(P)H:quinone reductase in cultured cells.

 Cancer Prevention:Preservation of Normal Cell Cycle Regulation:

 Following DNA damage, the cell cycle can be transiently arrested to allow for DNA repair or activation of pathways leading to cell death (apoptosis) if the damage is irreparable. Defective cell cycle regulation may result in the propagation of mutations that contribute to the development of cancer. Resveratrol has been found to induce cell cycle arrest when added to cancer cells grown in culture.

 Cancer Prevention:Inhibition of Proliferation and Induction of Apoptosis:

 Unlike normal cells, cancer cells proliferate rapidly and lose the ability to respond to cell death signals by undergoing apoptosis. Resveratrol has been found to inhibit proliferation and induce apoptosis in a number of cancer cell lines.

 Cancer Prevention:Inhibition of Tumor Invasion and Angiogenesis:

 Cancerous cells invade normal tissue aided by enzymes called matrix metalloproteinases. Resveratrol has been found to inhibit the activity of at least one type of matrix metalloproteinase. Invasive tumors must also develop new blood vessels to fuel their rapid growth by a process known as angiogenesis. Resveratrol has been found to inhibit angiogenesis in vitro.
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 Cancer Prevention:Anti-inflammatory Effects:

 Inflammation promotes cellular proliferation and angiogenesis and inhibits apoptosis. Resveratrol has been found to inhibit the activity of several inflammatory enzymes in vitro, including cyclooxygenase and lipoxygenase.

 Cardiovascular Disease Prevention:Inhibition of Vascular Cell Adhesion Molecule Expression:

 Atherosclerosis is now recognized as an inflammatory disease, and several measures of inflammation are associated with increased risk of myocardial infarction (heart attack). One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white blood cells from the blood to the artery wall by vascular cell adhesion molecules. Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells.

 Cardiovascular Disease Prevention:Inhibition of Vascular Smooth Muscle Cell Proliferation:

 The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis. Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture.

 Cardiovascular Disease Prevention:Stimulation of Endolethelial Nitric Oxide Synthase (eNOS) Activity:

 eNOS is an enzyme that catalyzes the formation of nitric oxide (NO) by vascular endothelial cells. NO is needed to maintain arterial relaxation (vasodilation), and impaired NO-dependent vasodilation is associated with increased risk of cardiovascular disease. Resveratrol has been found to stimulate eNOS activity in cultured endothelial cells

 Cardiovascular Disease Prevention:Inhibition of Platelet Aggregation:

 Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke. Resveratrol has been found to platelet aggregation in vitro.

 Note: It is important to keep in mind that that many of the biological activities discussed above were observed in cells cultured in the presence of resveratrol at higher concentrations than are likely to be achieved in humans consuming resveratrol orally.
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Reference:

• What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.

Article Information:

♥The article and literature was edited by herbalist of MDidea Extracts Professional.It runs a range of online descriptions about the titled herb and related phytochemicals,including comprehensive information related,summarized updating discoveries from findings of herbalists and clinical scientists from this field.The electronic data information published at our official website www.mdidea.com and www.mdidea.net,we tried best to update it to latest and exact as possible.
♣ last edit date:Jan 15th 2013 at 14:30