What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.

Anti-platelet effects of trans-resveratrol from Polygonum cuspidatum Extract.

Polygonum Cuspidatum Extract Resveratrol CAS.NO 510-36-0 photo picture image Transresveratrol has been reported to have a variety of anti-inflammatory, anti-carcinogenic, anti-fungal and anti-platelet effects.

In platelet-rich plasma of healthy humans, the application of resveratrol has been shown to counteract the induction of collagen which causes platelets to aggregate. In addition, resveratrol inhibits the formation of lipooxygenase products which are involved in inflammatory processes, among them platelet aggregation (Bertelli 1995).

Recently, tranresveratrol and other related phenolic compounds including trans-3,3,5,5-tetrahydroxy-4-methoxystilbene and yuccaols A and C were isolated from the bark of Yucca schidigera by some researchers.

They do research to evaluate in vitro the effects of these compounds on platelet aggregation induced by thrombin and ADP. Pretreatment of platelets with transresveratrol or other tested phenolics (1-25 g/ml) slightly reduced platelet aggregation stimulated by 5 M ADP (P less than 0.05) or 10 M ADP (P less than 0.005).

The comparison of the inhibitory effects of tested compound in thrombin-induced platelet aggregation revealed that phenolic showed even stronger antiplatelet actions than resveratrol.

These compounds also had an inhibitory effect on the thrombin-induced enzymatic platelet lipid peroxidation determined as the level of thiobarbituric acid reactive substances.