What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.

Anti-HIV Effects of transresveratrol.

Polygonum Cuspidatum Extract Resveratrol CAS.NO 510-36-0 photo picture image Alonso Heredia, PhD, from the Institute of Human Virology at the University of Maryland gave an interesting presentation on a new, natural anti-HIV agent.Materials used with transresveratrol purchased bulk and low price available from Polygonum cuspidatum Root P.E. provided by MDidea Group. I n the scientific literature, this substance has been reported to have anti-cancer, anti-inflammation and anti-atherosclerotic (hardening of the arteries) benefits.

In laboratory studies, transresveratrol was synergistic (enhanced effect by combining) with either Videx (ddI, didanosine), Retrovir (AZT, zidovudine) or Hivid (ddC, zalcitabine). The greatest degree of synergism was with Videx. The agent even reverses Videx resistance when combined with it.

Interestingly, when transresveratrol was combined with Videx in the laboratory, the combination had anti-HIV effects on macrophages and even resting lymphocytes. This latter lymphocyte pool represents a reservoir of HIV that is not eradicated even after 2-3 of HAART therapy. When transresveratrol and Videx were removed from white cell cultures originally infected with HIV, no viral rebound occurred even after 14 days.

Transresveratrol works, in part, by increasing the percentage of cells in the "S" phase of cellular growth.This may decrease the number in the resting phase and account for its benefits for the resting pool of lymphocytes.

Mice Antiviral effect Acquired immunodeficiency syndrome (AIDS):

Scientists from China identified the effect of Polygonum cuspidatum water extract on C57BL/6 mice infected with LP BM5 murine leukemia virus (MuLV) was investigated taking spleen index, viral antigen positive cell, serum IgG level and ConA response as parameters. And demonstrated that Polygonum cuspidatum water extract can partly inhibit LP BM5 MuLV induecd splenomegaly, immunodeficiency and viremia of C57BL/6 mice.

Antiviral effect of Polygonum cuspidatum water extract is more effective before or at the same time of virus inoculation than after virus inoculation. It indicates that the earlier treatment, the better. Continual treatment can partly improve splenomegaly and ConA response of infected mice, but the inhibition of Polygonum cuspidatum water extract on hypergrmmaglobulinemia of infected mice is non persistent.