What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.Polygonum Cuspidatum Extract.Resveratrol.

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Reveratrol and Cardiovascular Disease Prevention.

Polygonum Cuspidatum Extract Resveratrol CAS.NO 510-36-0 photo picture image Red Wine Polyphenols:

 Significant reductions in cardiovascular disease risk have been associated with moderate consumption of alcoholic beverages. The "French Paradox",the observation that mortality from coronary heart disease is relatively low in France despite relatively high levels of dietary saturated fat and cigarette smoking,led to the idea that the regular consumption of red wine might provide additional protection from cardiovascular disease. Red wine contains resveratrol and even higher levels of flavonoids. These polyphenolic compounds have antioxidant, anti-inflammatory, and other potentially anti-atherogenic effects in the test tube and in some animal models of atherosclerosis. However, it is not yet known whether increased consumption of polyphenols from red wine provides any additional protection from cardiovascular disease beyond that associated with its alcohol content. The results of epidemiological studies addressing this question have been inconsistent. While some large prospective studies found that wine drinkers were at lower risk of cardiovascular disease than beer or liquor drinkers, others found no difference. Socioeconomic and lifestyle differences between people who prefer wine and those who prefer beer or liquor may explain part of the additional benefit observed in some studies. Several studies have found that people who prefer wine tend to have higher incomes, more education, smoke less, and eat more fruits and vegetables and less saturated fat than people who prefer other alcoholic beverages. Although moderate alcohol consumption has been consistently associated with 20-30% reductions in coronary heart disease risk, it is not yet clear whether red wine polyphenols confer any additional risk reduction.

 Resveratrol:

 Resveratrol has been found to exert a number of potentially cardioprotective effects in vitro, including the inhibition of platelet aggregation, promotion of vasodilation by enhancing the production of NO and inhibition of inflammatory enzymes. However, the concentrations of resveratrol required to produce these effects are often higher than those that have been measured in human plasma after oral consumption of resveratrol. The results of some animal studies suggest that high oral doses of resveratrol could decrease the risk of thrombosis (clot formation) and atherosclerosis, but at least one study found increased atherosclerosis in animals fed resveratrol. Although its presence in red wine has stimulated a great deal of interest in the potential for resveratrol to prevent cardiovascular disease, there is currently no convincing evidence that resveratrol has cardioprotective effects in humans, particularly in the amounts present in 1-2 glasses of red wine

 Cancer:

 When added to cells cultured outside the body, resveratrol has been found to inhibit the proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic and thyroid cancers. In animal models, oral administration of resveratrol inhibited the development of esophageal, intestinal and mammary (breast) cancer induced by chemical carcinogens. However, oral resveratrol was not effective in inhibiting the development of lung cancer induced by cigarette smoke carcinogens, and the effects of oral resveratrol administration on mice that are genetically predisposed to colon cancer have been mixed. It is not known whether high intakes of resveratrol can help prevent cancer in humans. Studies on human metabolism of resveratrol suggest that even very high dietary intakes of resveratrol may not result in tissue levels that are high enough to realize most of the protective effects demonstrated in cell culture studies.

 Longevity:

 Caloric restriction is known to extend the lifespans of a number of species, including mammals. In yeast, caloric restriction stimulates the activity of an enzyme known as Sir2. Providing resveratrol to yeast increased Sir2 activity in the absence of caloric restriction and extended the replicative lifespan of yeast by 70%. Resveratrol feeding also extended the lifespans of worms (C. elegans) and fruit flies (D. melanogaster) by a similar mechanism, but it is not known whether resveratrol will have similar effects in higher animals. Although resveratrol increased the activity of the homologous human enzyme (Sirt1) in the test tube, it is not known whether resveratrol can extend the human lifespan. Moreover, the resveratrol concentrations required to increase human Sirt1 activity were considerably higher than concentrations that have been measured in human plasma after oral consumption.

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Reference:

citations1.What is Transresveratrol?Basic Information,Super Function and Researches of resveratrol and Polygonum Cuspidatum Extract.Polygonum Cuspidatum Extract.Resveratrol.

last edit date:5th,May.2009.