What is Rosmarinic Acid?Super Function of RosA,Rosmarinic Acid?

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Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy.

Perilla Extract Perilla Ocymoides Extract EINECS ELINCS No.:290-151-0 CAS 90082-61-4 photo picture image Perilla frutescens Britton (perilla, Labiatae) is a medicinal herb prescribed in formula effective for allergic diseases such as bronchial asthma.

 Study research was conducted to evaluate the anti-allergic effect of orally administered perilla decoction and to identify the active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction, which is one of the animal models for type I allergy.

 Perilla decoction significantly suppressed PCA-reaction, and the inhibition % at the dose of 500 mg/kg was 43%.

 The perilla decoction contains 5.3% of luteolin 7-O-[beta-glucuronosyl(2-->1)beta-glucuronide], 1.6% of apigenin 7-O-[beta-glucuronosyl(2-->1)beta-glucuronide], 0.49% of scutellarin, and 2.5% of rosmarinic acid (weight of compound/dried weight of perilla decoction %), respectively.

 When these constituents were orally administered to mice at the dose equivalent to 500 mg/kg of perilla decoction, rosmarinic acid and apigenin 7-O-[beta-glucuronosyl(2-->1)beta-glucuronide] significantly suppressed PCA-reaction, and their inhibition % was 41% (p less than 0.01) and 32% (p less than 0.05), respectively.
 Since the inhibition % or perilla decoction and rosmarinic acid were nearly equal, the anti-allergic effect of perilla decoction depends primarily on rosmarinic acid.

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citations1.What is Rosmarinic Acid?Super Function of RosA,Rosmarinic Acid?

last edit date:5th,May.2009.