Rhodiola rosea.Rosavin.Salidroside.Narrative History,Function,Uses and Application of Rhodiola rosea.Rhodiola Rosea Extract.

Experimental Studies and Application Study.

Adaptogenic Activity.:

Rhodiola rosea appears to offer generalized resistance against physical, chemical, and biological stressors in rats and other animals studied. Evidence also suggests cardioprotective and anticancer benefits in animals.

In the test of swimming "to the limit," Rhodiola rosea administration increased the swimming time of rats 135-159 percent. Working capacity of the rats consistently improved throughout the supplementation period.

Eggs from the freshwater snail Lymnaea stagnalis were incubated in water extracts of Rhodiola rosea and subsequently exposed to a variety of environmental stressors, including heat shock (43 for four minutes), oxidative stress (600 menadione for two hours), and heavy metal-induced stress (one-hour exposure to 150 copper sulphate or 20 cadmium chloride). Exposure to these environmental stressors kills 80-90 percent of larvae within four days post-exposure. Pre-incubation with Rhodiola rosea extract afforded a significant degree of non-specific resistance against each of these environmental stressors as measured by rate of survival. While only nine percent of the control population survived exposure to heat shock, approximately 90 percent of snail larvae pre-incubated with Rhodiola rosea (40.5 mg/ml) survived. Pre-incubation with Rhodiola resulted in non-specific resistance to oxidative stress (survival of approximately 68 percent) and heavy metal stress (approximately 28-35 percent of larvae survived depending on the metal exposure).

Two experiments have suggested possible benefit on various aspects of learning and memory in rats under certain experimental conditions. Rhodiola rosea extract administered orally at a dose of 0.1 mL/day for 10 days resulted in a non-significant trend toward protection against impairments in memory, as assessed by step-down passive avoidance, induced by electroshock in rats.Rhodiola rosea extract was administered in a single dose of 0.10 mL. Improvements in both learning and memory retention, as determined by using a maze test with negative reinforcement, were observed. Repeated dosing with the same quantity of the extract over a 10-day period generated significant improvement in long-term memory as assessed by the maze test with negative enforcement and the "staircase" method with positive enforcement. However, in this experiment two other doses were tested (0.02 and 1.0 mL) and were found to have no substantial effect on learning and memory.

This suggests the possibility of an efficacious dose of Rhodiola rosea administration, above and below which beneficial physiological effects might be less likely. In the other experimental conditions investigated (active avoidance with negative reinforcement using a "shuttle box" and passive avoidance using "step down" and "step through") no beneficial effects on either learning or memory were observed with any of the administered doses of Rhodiola rosea.

Cardioprotective Activity.:

Rhodiola rosea has been shown to moderate against stress-induced damage and dysfunction in cardiovascular tissue. Treatment with Rhodiola rosea extract prevents the decrease in cardiac contractile force secondary to environmental stress in the form of acute cooling and contributes to stable contractility. In animals, acute cooling leads to a decrease in myocardial contractile activity that partially recovers during the first 18 hours after the cold-stress is removed. This recovery is viewed as only partial, since the heart tissue is incapable of stable contractility during perfusion. Pretreatment with Rhodiola rosea extracts appears to create a beneficial adaptive response in this type of stress. When Rhodiola pretreated rats were exposed to acute cooling, the decrease in contractility was prevented and stable contractility of heart tissue occurred during perfusion.

Other reports suggest administration of Rhodiola rosea protects cardiovascular tissue from stress-induced catecholamine release and mitigates against adrenaline-induced arrhythmias in rats. The antiarrhythmic effect of Rhodiola rosea is suggested to be secondary to an ability to induce opioid peptide biosynthesis13 and related to the stimulation of peripheral kappa-opioid receptors.

Anticancer Activity.:

Administration of Rhodiola rosea appears to have potential as an anticancer agent, and might be useful in conjunction with some pharmaceutical antitumor agents. In rats with transplanted solid Ehrlich adenocarcinoma and metastasizing rat Pliss lymphosarcoma, supplementation with Rhodiola rosea extract inhibited the growth of both tumor types, decreased metastasis to the liver, and extended survival times.Administration of Rhodiola rosea extract also directly suppressed the growth of and the extent of metastasis from transplanted Lewis lung carcinomas.When Rhodiola rosea extract was combined with the antitumor agent cyclophosphamide in these same tumor models, the antitumor and antimetastatic efficacy of drug treatment was enhanced. The authors also commented that, "complete abrogation of the haematotoxicity of cyclophosphamide" was observed. The chemotherapeutic drug Adriamycin is known to induce pronounced liver dysfunction, generally reflected by an increase in transaminase levels. In animal experiments, adding Rhodiola rosea extract to a protocol with Adriamycin resulted in an improved inhibition of tumor dissemination (as compared to that found with Adriamycin alone), and the combined protocol prevented liver toxicity.

Application Study.:Muscle Superman

There is some herb formula named Muscle Superman formulated following: These three anabolic supplements push muscle growth from a variety of angles:

Believe it or not, the best way to pack on lean muscle mass isn't by concentrating just on increasing muscle growth. You need a multitiered approach that includes 1) boosting the processes in muscle fibers that lead to more mass and 2) enhancing other physiological systems that can influence muscle hypertrophy.

To build more muscle, testosterone isn't the only concern ~ the immune and endocrine systems must be running at full efficiency. Keeping your thyroid gland in optimal health helps keep muscles growing because thyroid hormones are actually anabolic. As for your immune system, if it's run down due to excessive stress from superintense training or other daily stressors, your body won't spend energy on growth. Instead, it'll focus on kicking up your immune system in an effort to fight off any foreign invaders that could be making you sick.

Taking a supplement stack that stimulates protein synthesis in muscle fibers (aka muscle growth) and enables the body to better deal with stress is a smart idea. This jump-starts the process of muscle growth and keeps it ramped up. The following three supplements, when taken together, do just that. They'll help increase protein synthesis, strength and endurance, and defend against stress and fatigue.

20-Beta-Ecdysterone:

This phytoecdysteroid ~ a plant chemical produced to defend against insects ~ is actually a steroid hormone that has potent anabolic properties. Research shows it can enhance lean muscle growth, even in instances when calorie intake was reduced. The mechanism involves pathways in muscle fibers that cause the muscle to synthesize more muscle protein. And the more muscle protein a muscle has, the bigger it is.

Researchers say 20-beta-ecdysterone provides numerous other effects, such as increasing muscle endurance by enhancing the amount of adenosine triphosphate (ATP) ~ the energy currency of all cells ~ in muscle cells. It also increases insulin sensitivity, not only allowing insulin to enhance glycogen storage in muscle cells but having a more potent anabolic effect on them.

Dose: Look for products that give you about 2~3 mg per pound of bodyweight per day, or about 300~800 mg total daily for those weighing between 150 and 250 pounds. The best way to take ecdysterone is in 3~6 doses daily with food.

Rhodiola Rosea:

Considered an effective adaptogen, this plant increases the body's resistance to a variety of chemical, biological and physical stressors, such as intense exercise, anxiety, pollution, poor sleep habits and emotional stress. Regardless of the source, stress leads to the same outcome: disturbances in key physiological systems in your body.

Two systems most at risk from stress are the immune and endocrine systems. While an immune system compromised by stress leaves you highly susceptible to colds and infections, taking rhodiola allows your body to better deal with most stressors to help ward off infections and keep growing. When your endocrine system is battered by stressors, most anabolic hormones, such as testosterone, growth hormone, IGF-1 and the thyroid hormones, become blunted. And since these guys are critical drivers of muscle growth, muscle growth gets blunted, too.

To add insult to injury, the catabolic hormone cortisol peaks in times of stress, inhibiting testosterone's effects in muscle cells and instigating muscle breakdown. Taking an adaptogen, such as rhodiola rosea, however,helps prevent the blunting of anabolic hormones and inhibit the rise of catabolic hormones, ultimately leading to greater gains in muscle size and strength.

One way rhodiola works is by increasing cellular ATP and creatine phosphate levels, which should lead to not only greater muscle endurance but also muscle strength.

Dose: The recommended dosage is 100~300 mg daily of a standardized extract yielding a minimum of 3% rosavins and 0.8%~1% salidrosides (3:1 ratio of rosavins to salidrosides). Take it in 2~3 divided doses throughout the day.

Bacopa Monnier:

An adaptogen like rhodiola, this herb has strong anti-stress and antioxidant properties, plus it promotes memory and concentration and enhances visual processing (great for athletes whose sports require hand-eye coordination). While its adaptogenic properties are great for stabilizing the body's critical systems so muscle growth adaptations can take place, bacopa's effects on the thyroid gland may be the most critical. Research shows it can increase anabolic thyroid hormone levels by more than 40%, which can have a dramatic impact on muscle growth and plays a major role in regulating the metabolic rate. Higher thyroid hormone levels mean you burn more calories in a typical day, so you can add muscle while keeping fat off.

Dose:Take 100~300 mg of bacopa monnieri extract standardized to at least 20% bacosides in 2~3 divided doses throughout the day. M and F

Guide or Dosage Suggestions:

Take these three supplements in several divided doses per day. Supplement Daily Dose:20-beta-ecdysterone 300~800 mg,Rhodiola rosea 100~300 mg,Bacopa monnieri 100~300 mg.
Rhodiola Rosea Extract.INCI Name Rhodiola Rosea Root Extract EINECS ELINCS No 306-819-2 CAS 97404-52-9 Salidroside 10338-51-9 Rosavin 84954 -92 -7 Siberian Rhodiola Rosea Root Extract,Rhodiola extract,Rhodiola rosea ethanol extract,golden root photo picture image

An Example:Eva Birath-a swedish bodybuilder

This is what I eat:Fish, shrimps, turkey, chicken, eggs and red meat with salads and vegetables. I use oil for cooking, casew and peanuts for snacks.

This I don't eat:Diary products. sugar, almost no complex carbohydrates like pasta, rice, potatoes and soft bread.

Following an example of what I eat on a weekday:

Supplements:Multivitamin,Vitamin C,Glocusamin and MSM,Aminoacids,Rhodiola Rosea,Tribulus,E-Bol.

Food:

9.00 Wholeweat bread with two eggs and caviar
12.00 Chicken 150g, salad with avocado, lettuce, peas and tomato
15.00 Banana and 1 dl casew or peanuts
17.30 Two chicken filets with salad, peppers avocado and broccoli and some oil
21.00 Shrimps 175g, tomato, wholeweat bread and 1dl casew or peanuts