The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

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Soy Isoflavones and Hormone-associated Cancers.

Soy Bean Extract INCI Name Glycine Soja Extract Soy Isoflavones Genistein Daidzein CAS 84776-91-0 Genistein CAS 446-72-0 Daidzein CAS486-66-8 photo picture image Breast Cancer:

 Breast cancer rates in Asia, where average isoflavone intakes from soy foods range from 11-47 mg/d, are lower than breast cancer rates in the Western countries where average isoflavone intakes in non-Asian women may be less than 2 mg/d. However, many other hereditary and lifestyle factors could contribute to this difference in breast cancer rates. Most epidemiological studies have not found that women with higher soy intakes are at lower risk of breast cancer, with the possible exception of women who had higher soy intakes during adolescence. At present, there is no evidence that taking soy isoflavone supplements decreases breast cancer risk. See the article on Legumes for more information about soy consumption and breast cancer risk.

 Endometrial Cancer:

 Because the development of endometrial (uterine) cancer is related to prolonged exposure to unopposed estrogens, it has been suggested that high intakes of phytoestrogens with anti-estrogenic activity in uterine tissue could be protective against endometrial cancer. In support of this idea, two retrospective case-control studies found that women with endometrial cancer had lower intakes of soy isoflavones from foods compared to cancer-free control groups. However, supplementation of postmenopausal women with soy protein providing 120 mg/d of isoflavones for 6 months did not prevent endometrial hyperplasia induced by the administration of exogenous estradiol. Although limited evidence from case-control studies suggests that higher dietary intakes of soy foods may be associated with lower endometrial cancer risk, there is no evidence that taking soy isoflavone supplements decreases endometrial cancer risk.

 Prostate Cancer:

 Mortality from prostate cancer is much higher in the US than in Asian countries, such as China. However, epidemiological studies do not provide consistent evidence that high intakes of soy foods are associated with reduced prostate cancer risk. See the article on Legumes for more information about soy foods and prostate cancer risk. The results of cell culture and animal studies suggest a potential role for soy isoflavones in limiting the progression of prostate cancer. Although soy isoflavone supplementation for up to one year did not significantly decrease serum prostate specific antigen (PSA) concentrations in men without confirmed prostate cancer, soy isoflavone supplementation appeared to slow rising serum PSA concentrations associated with prostate tumor growth in two small studies of prostate cancer patients. Although such preliminary findings are encouraging, the results of larger randomized controlled trials, which are currently ongoing, are needed to determine whether soy isoflavone supplementation can play a role in the prevention or treatment of prostate cancer.

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citations1.The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

last edit date:6th,May.2009.