The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

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Genistein mimics human estrogens.

Soy Bean Extract INCI Name Glycine Soja Extract Soy Isoflavones Genistein Daidzein CAS 84776-91-0 Genistein CAS 446-72-0 Daidzein CAS486-66-8 photo picture image In research collaborations with scientists in the Department of Medicinal Chemistry here at Ohio State, we are investigating the nature of these potentially conserved signaling and signal transduction pathways. So far evidence suggests possible parallels in apoptotic cell death, estrogen-like and interleukin signaling pathways.

 Shown at left is the soybean isoflavone genistein (the small grey structure with red hydroxy groups) binding to the human estrogen receptor ER-Alfa.

 Genistein is one of the most potent phytoestrogens. It mimics human estrogens by binding to both ER-Alfa and ER-Beta and has promising anti-breast cancer activity.

 Genistein is also a central signal in soybean for the potentiation of defense responses. Interestingly, human estrogens such as estradiol also activate defense potentiation in soybean, possibly by acting as a genistein mimic.

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citations1.The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

last edit date:6th,May.2009.