The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.
Article Content:
- .Basic Info of Soy Isoflavones.
- .Introduction and Brief Benefits of Soy Isoflavones.
- .Actions and Pharmacology.
- .Women's health and Isoflavones.
- .Suggestions and Administration.
- .Soy Isoflavones Metabolism.
- .Soy Isoflavones Estrogenic and Anti-Estrogenic Activities.
- .Soy Isoflavones Estrogen Receptor-Independent Activities.
- .Soy Isoflavones Prevent Cardiovascular Disease.
- .Soy Isoflavones and Hormone-associated Cancers.
- .Soy Isoflavones Prevent Osteoporosis.
- .Soy Isoflavones Help Prevent Cognitive Decline.
- .Soy Isoflavones Treatment Menopausal Symptoms.
- .Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.
- .Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women.
- .What is genistein?
- .Genistein mimics human estrogens.
- .Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor Beta.
- .Estrogenic Effects of Genistein.
- .Effect of genistein to control postmenopausal symptoms and bone loss.
- .Safety and Acute toxicity.
- .How Search engine think about Genistein.
- .Research Update and latest findings of Soy Isoflavones.Daidzein.Daidzin.Genistein.Genistin related.
Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor Beta.
The structural similarity, but non-identity, between 17b-oestradiol and the soy phytoestrogen genistein suggests that the two compounds will have actions that may be identical in some target biological systems, but different in others. Epidermal growth factor (EGF)-stimulated proliferation of human mammary epithelial cells (that do not express the oestrogen receptor) was significantly suppressed at genistein concentrations (5~10 uM) that are attainable physiologically.
Others have shown previously that transforming growth factor b (TGFBeta) has similar growth-inhibitory effects on human cells. Analysis of the conditioned medium of human mammary epithelial cells exposed to genistein plus EGF showed increased levels of TGFBeta relative to those in the medium of cells exposed to EGF or genistein alone. Related experiments in a primate model of menopause demonstrated that ingestion of soy containing isoflavones was correlated with the suppression of neurodegeneration-relevant phosphorylation of the microtubule-associated protein tau, while intake of Premarin (a hormone replacement therapy that is commonly prescribed for women) was not correlated. The results discussed here indicate that genistein, and probably other related phytoestrogens, have pleiotropic actions, some of which may involve TGFBeta activity.
Reference:
1.The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.
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