The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.
Article Content:
- .Basic Info of Soy Isoflavones.
- .Introduction and Brief Benefits of Soy Isoflavones.
- .Actions and Pharmacology.
- .Women's health and Isoflavones.
- .Suggestions and Administration.
- .Soy Isoflavones Metabolism.
- .Soy Isoflavones Estrogenic and Anti-Estrogenic Activities.
- .Soy Isoflavones Estrogen Receptor-Independent Activities.
- .Soy Isoflavones Prevent Cardiovascular Disease.
- .Soy Isoflavones and Hormone-associated Cancers.
- .Soy Isoflavones Prevent Osteoporosis.
- .Soy Isoflavones Help Prevent Cognitive Decline.
- .Soy Isoflavones Treatment Menopausal Symptoms.
- .Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.
- .Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women.
- .What is genistein?
- .Genistein mimics human estrogens.
- .Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor Beta.
- .Estrogenic Effects of Genistein.
- .Effect of genistein to control postmenopausal symptoms and bone loss.
- .Safety and Acute toxicity.
- .How Search engine think about Genistein.
- .Research Update and latest findings of Soy Isoflavones.Daidzein.Daidzin.Genistein.Genistin related.
Safety and Acute toxicity.
Genistein:
Chemical Name: Isoflavone,4',5,7-trihydroxy-
CAS: 446-72-0.Molecular Formula: C15-H10-O5.Weight: 270.25
Synonyms: 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-(4-hydroxyphenyl)-;C.I.75610;Differenol A;Genistein;Genisteol;Genisterin;Prunetol;Sophoricol;4',5,7-Trihydroxyisoflavone;5,7,4'-Trihydroxyisoflavone.
Acute toxicity(LD50):
LD-Lethal dose,Intraperitoneal.Rodent-mouse.>500mg/kg.
Details of toxic effects not reported other than lethal dose value.
Reference: JANTAJ Journal of Antibiotics.V.2-5,1948-52;V.21-1968-Volume(issue)/page/year:39,606,1986.
Reproductive Data:
TDLo-Lowest published toxic dose.Subcutaneous.Rodent-rat.125mg/kg.
Sex/Duration:female 16~20days(s) after conception.
Toxic Effects: Reproductive-Specific Development Abnormalities-urogenital system.
Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.
TDLo-Lowest published toxic dose.subcutaneous.Rodent-rat.625mg/kg.
Sex/Duration:female 16~20 day(s) after conception.
Toxic Effects: Reproductive-Effects on Newborn-growth statistics(e.g.%,reduced weight gain).
Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.
TDLo-Lowest published toxic dose.Oral.Rodent-mouse.1680mg/kg.
Sex/Duration:female 21 day(s) pre-mating.
Toxic Effects:Reproductive.Maternal Effects.other effects.
Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.
TDLo-Lowest published toxic dose.Oral.Rodent-mouse.13200mg/kg.
Sex/Duration:male 22 day(s) pre-mating.
Toxic Effects: Reproductive-fertility-male fertility index(e.g.#males impregnating females per#males exposed to fertile nonpregnant females).
Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.
TDLo-Lowest published toxic dose.Oral.Rodent-mouse.18600mg/kg.
Sex/Duration:male 31 day(s) pre-mating.
Toxic Effects: Reproductive-Effects on Newborn-stillbirth.
Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.
Mutagenic Data.
DNA damage.Test system:Human Cells-not otherwise specified.50mg/L.
Reference: CNREA8 Cancer Research.(Public Ledger Building,Suit 816,6th Chestnut Sts.,Philadelphia,PA 19106)V.1-1941-Volume(issue)/page/year:50,2618,1990.
DNA damage.Test system:Human Cells-not otherwise specified.50umol/L.
Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.
Mutation test systems-not otherwise specified.Test system:Human Cells-not otherwise specified.45 umol/L.
Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.
Micronucleus test.Test sytem:Rodent-hamster Lung.18 umol/L.
Reference:FCTOD7 Food and Chemical Toxicology.(Pergamon Press Inc.Maxwell House,Fairview Park,Elmsford,NY 10523) V.20-1982-Volume(issue)/page/year:35,605,1997.
Daidzein:
Chemical Name: 4H-1-Benzopyran-4-one,7-hydroxy-3-(4-hydroxyphenyl)-
CAS: 486-66-8.Molecular Formula: C15-H10-O4.Weight: 254.25
Beilstein No.:0231523(5-18-04-00089.Beilstein Handbook Reference)
Synonyms: Daidzein;Daidzeol;4'7-Dihydroxyisoflavone;7,4'-Dihydroxyisoflavone;7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Isoflavone,4'7-dihydroxy-;K251b.
Acute toxicity(LD50):
LD-Lethal dose,Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
Details of toxic effects not reported other than lethal dose value.
Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.
Genistin:
Chemical Name:4H-1-Benzopyran-4-one,7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-
CAS: 4529-59-9.Molecular Formula: C21-H20-O10.Weight: 432.41
Beilstein No.:0064479(4-18-00-02732.Beilstein Handbook Reference)
Synonyms:Genistein,7-beta-D-glucopyranoside;Genistein,7-O-beta-D-glucoside;Genistin;Genistine;Genistoside.
Acute toxicity(LD50):
LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
Details of toxic effects not reported other than lethal dose value.
Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.
Daidzin:
Chemical Name:4H-1-Benzopyran-4-one,7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hydroxy-
CAS: 552-66-9.Molecular Formula: C21-H20-O9.Weight: 416.41
Beilstein No.:0059741(4-18-00-01808.Beilstein Handbook Reference)
Synonyms:Daidzein 7-glucoside;Daidzein 7-O-glucoside;Daidzin;Daidzoside;7-(beta-D-Glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one.
Acute toxicity(LD50):
LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
Details of toxic effects not reported other than lethal dose value.
Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.
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1.The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.
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