Green Tea Modern Benefit,Applicable Uses and Research New findings.Green Tea Extract.Green Tea Polyphenols.

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Tea Safety and Administration.

Green Tea Extract INCI Name Camelia Sinensis Extract EINECS ELINCS No 283-519-7 CAS 84650-60-2 Tea Polyphenols photo picture image Adverse Effects of Tea and Tea Extracts:

 Tea is generally considered to be safe, even in large amounts. However, two cases of hypokalemia (abnormally low serum potassium) in the elderly have been attributed to excessive consumption of black and oolong tea (3-14 liters/day). Hypokalemia is a potentially life-threatening condition that has been associated with caffeine toxicity.

 Cancer patients in clinical trials of caffeinated green tea extracts who took 6 grams/day in 3-6 divided doses have reported mild to moderate gastrointestinal side effects, including nausea, vomiting, abdominal pain, and diarrhea. Central nervous system symptoms including agitation, restlessness, insomnia, tremors, dizziness, and confusion have also been reported. In one case confusion was severe enough to require hospitalization. These side effects were likely related to the caffeine in the green tea extract. In a four-week clinical trial that assessed the safety of decaffeinated green tea extracts (800 mg/day of EGCG) to healthy individuals, a few of the participants reported mild nausea, stomach upset, dizziness or muscle pain.

 Pregnancy and Lactation:The safety of tea extracts or supplements for pregnant or breastfeeding women has not been established. Some organizations advise pregnant women to limit their caffeine consumption to 300 mg/day because higher caffeine intakes have been associated with increased risk of miscarriage and low birth weight in some epidemiological studies.Green tea contains caffeine and as such should not be used in large quantities while pregnant or nursing or by people who are not allowed caffeine.

 Drug Interactions:Green teaExcessive green tea consumption may decrease the therapeutic effects of the anticoagulant, warfarin (Coumadin). Such an effect was documented in one patient who began drinking one half gallon to one gallon of green tea daily. It is probably not necessary for people on warfarin therapy to avoid green tea entirely. However, large quantities of green tea may decrease its effectiveness.

 Drug Interactions:CaffeineA number of drugs can impair the metabolism of caffeine, increasing the potential for adverse effects from caffeine. They include cimetidine (Tagamet), disulfiram (Antabuse), estrogens, fluoroquinolone antibiotics (e.g., ciprofloxacin, enoxacin, norfloxacin), fluconazole (Diflucan), fluvoxamine (Luvox), mexilitine (Mexitil), riluzol (Rilutek), terbinafine (Lamisil) and verapamil (Calan). High caffeine intakes may increase the risk of toxicity of some drugs, including albuterol (Alupent), clozapine (Clozaril), ephedrine, epinephrine, monoamine oxidase inhibitors, phenlypropanolamine and theophylline. Abrupt caffeine withdrawal has been found to increase serum lithium levels in people taking lithium, and may increase the risk of lithium toxicity.

 Nutrient Interactions:Nonheme IronFlavonoids in tea can bind nonheme iron, inhibiting its intestinal absorption. Nonheme iron is the principal form of iron in plant foods, dairy products and iron supplements. The consumption of one cup of tea with a meal has been found to decrease the absorption of nonheme iron in that meal by about 70%. To maximize iron absorption from a meal or iron supplements, tea should not be consumed at the same time.

 Safety and Acute toxicity:

 EGCg:
 Acute toxicity(LD50):LD50: Lethal dose,50 percent kill.Oral.Rodent-mouse.2170 mg/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:KSRNAM Kiso to Rinsho.Clinical Report.V.1-1960-Volume(issue)/page/year:21,4601,1987.

 EC(Epicatechin):

 Acute toxicity(LD50):LD50: Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.1gm(1000 mg)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:PLMEAA Planta Medica.(Georg Thieme Verlag,Postfach 732,D-7000 Stuttgart 1,Fed.Rep.Ger.)V.1-1953-Volume(issue)/page/year:42,75,1981.
 Mutagenic Data.:Sister chromatid exchange. Test System:Human Lymphocyte. Dose/Period:500 mg/L.
 Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB211,1000 AE.Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:246,205,1991

 Epigallocatechin:
 Acute toxicity(LD50):LD50: Lethal dose,50 percent kill.Oral.Rodent-mouse.>1gm(1000 mg)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:JKXXAF.(U.S.Patent and Trademark Office,Foreign Patents,Washington,DC20231) Volume(issue)/page/year:#93-944

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citations1.Green Tea Modern Benefit,Applicable Uses and Research New findings.Green Tea Extract.Green Tea Polyphenols.

last edit date:8th,May.2009.