Ursolic acid:Actions,Commonly Known Benefit and Research.

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Administration and Dosage.

Loquat Leaf extract.Glossy privet leaf Extract.Ligustrum Lucidum Extract.Loquat Leaf extract.Glossy privet leaf Extract.EINECS ELINCS No.:Ursolic acid.201-034-0,CAS 223749-57-3 Ursolic acid.77-52-1.Loquat Leaf extract.Pentacyclic Triterpenes photo picture image Clinical use of ursolic acid as an isolate is new, but oleanolic acid, which is nearly identical in structure but apparently milder in action, has been used for some time. Effective daily doses of oleanolic acid, based on its application in treatment of hepatitis, are reported in the range of 75-300 mg/day.

 For a standard dried hot water extract of an herb, which may contain about 2% of the PCTs, that dosage corresponds to use of about 4-15 grams of the extract, a large amount. Additional information on dosage of compounds of this type (see: Platycodon and other herbs with triterpene glycosides) indicates that a daily dose of about 300 mg is safe and potentially useful for long term applications and 600 mg is safe at least for short term dosage.

 Dr. Acharan Narula describes use of 300-500 mg or oleanolic acid as an intestinal anti-inflammatory and recommends Olenoate, a product of oleanolic acid in capsules of 100 mg each. For ursolic acid, in vitro studies have shown that it is about twice as effective as an anti-inflammatory compared to indomethacin, a potent NSAID that is administered in doses of just 50-100 mg/day; however, when converted to actual human use, the dose of ursolic acid needed may prove higher.

 Boswellic acid, another PCT that inhibits 5-LOX, and is used as an anti-inflammatory for arthritis, Crohn's disease, and asthma, is administered in doses of 400 mg 3 times a day of an extract standardized to contain 37.5% boswellic acids, which corresponds to 450 mg/day of boswellic acid.

 In general, the PCT dosage for anti-inflammatory effects appears similar to the dosage of NSAIDS.

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citations1.Ursolic acid:Actions,Commonly Known Benefit and Research.

last edit date:7th,May.2009.