Valeriana officinalis.Valerian and Medical Attributes.Valerian Root Extract.

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Safety and Acute toxicity:Valerienic acid

Valerian Root Extract INCI Name Valeriana Officinalis Extract EINECS ELINCS No.232-501-7 CAS 8057-49-6 Valerienic acid 109-52-4 photo picture image Acute toxicity (LD50):Valerienic acid

 LD50:Lethal dose,50 percent kill.Oral.Rodent-mouse.600mg/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:85GMAT "Toxicometric Parameters of Industrial Toxic chemicals Under Single Exposure,"Izmerov,N.F.,et al.,Moscow,Centre of International Projects,GKNT,1982 Volume(issue)/page/year:-,119,1982.

 LD50:Lethal concentration,50 percent kill.Inhalation.Rodent-mouse.4100 mg/m3/2H.
 Details of toxic effects not reported other than lethal dose value.
 Reference:85GMAT "Toxicometric Parameters of Industrial Toxic chemicals Under Single Exposure,"Izmerov,N.F.,et al.,Moscow,Centre of International Projects,GKNT,1982 Volume(issue)/page/year:-,119,1982.

 LD50:Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.3590 mg/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:JPPMAB Journal of Pharmacy and Pharmacology.(Pharmaceutical Soc.of Great Britian,1 Lambeth High St.,London SEI 7JN,UK)V.1- 1949- Volume(issue)/page/year:21,85,1969.

 LD50:Lethal dose,50 percent kill.Subcutaneous.Rodent-mouse.3590 mg/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:JPPMAB Journal of Pharmacy and Pharmacology.(Pharmaceutical Soc.of Great Britian,1 Lambeth High St.,London SEI 7JN,UK)V.1- 1949- Volume(issue)/page/year:21,85,1969.

 LD50:Lethal dose,50 percent kill.Intravenous.Rodent-mouse.1290 mg/kg.
 Toxic effects:
 Behavioral:altered sleep time(including change in righting reflex)
 Behavioral:convulsions or effect on seizure threshold.
 Lungs,Thorax,or Respiration:Respiratory depression.
 Reference:APTOA6 Acta Pharmacologica et Toxicologica.(Copenhagen,Denmark)V.1-59,1945-86.For publisher information,see PHTOEH Volume(issue)/page/year:18,141,1961.

 NOSH data:Valerienic acid

 NOHS:National Occupational Hazard Survey(1974)
 NOHS Hazard Code: 84212
 No. of Facilities: 21 (estimated)
 No. of Industries: 1
 No. of Occupations: 3
 No. of Employees: 497 (estimated)

 NOHS:National Occupational Hazard Survey(1983)
 NOHS Hazard Code: 84212
 No. of Facilities: 79 (estimated)
 No. of Industries: 2
 No. of Occupations: 8
 No. of Employees: 4510 (estimated)
 No. of Female Employees: 780 (estimated)

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citations1.Valeriana officinalis.Valerian and Medical Attributes.Valerian Root Extract.

last edit date:7th,May.2009.