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   Diosgenin is a primary material for synthesizing steriod hormone drugs. It is a raw material of 16-dehydro pregnenolone acetate. It synthesizes the hydrocortisone, prednisone, norethindronum, fluocinolone and daxamethasone etc. and kinds of steriod hormone drugs.

   Description:White crystalline powder, very soluble in gasoline and ethanol and insoluble in water

   Diosgenin showed a lack of progesterogenic action as was apparent from the absence of alveolar development even in the presence of exogenous estrogen.

   Estrogenic action of diosgenin on the mammary epithelium of ovariectomized (OVX) mouse has been reported. Diosgenin when administered (sc) at the dose levels of 20 and 40 mg/kg body weight for a period of 15 days stimulated the growth of mammary epithelium. This was indicated by the increase in DNA content, increase in number of ducts and appearance of terminal endbuds. There was a significant increase in the mammary development scores in the presence of diosgenin. Concomitant treatment of estrogen and diosgenin showed augmentation of estrogenic effect of diosgenin especially at the higher dose level (40 mg/kg body wt).

   suggested for:
   1. -chronic fatigue
   2. -loss of appetite
   3. -leukorrhea
   4. -immune deficiency
   5. -overall weakness and coldness in extremities
   6. -diarrhea
   7.-Anti-Aging
   8.-Enhanced mood, energy, and memory
   9.-Improved immune system
   10.-Boosted sex drive (especially in women)
   11.-Reduced Osteoporosis.Improved fat loss
   12.-More muscle mass
   13.-Reduced Autoimmune disorders
   14.-Less Heart Disease

   Wild Yam Extract Is Not Progesterone

   Most pharmaceutical grade progesterone is made from diogensin found in wild yams. Diosgenin is found in other plants as well but not in amounts significant enough to be of value. Diosgenin is converted into natural progesterone scientifically. There are no enzymes in the human body that will convert diosgenin, which is the active component of wild yams into progesterone. You can eat or rub on your skin all of the wild yam extract you like but the body will not convert it to progesterone. Diosgenin is still very useful in the body, however, and has been used by phytotherapists for centuries as an adaptagen. Whatever the effects of wild yam, it does not have the same benefits as natural progesterone.

   Many companies sell wild yam products containing diosgenin stating that they provide the same benefits as progesterone. It is also added to many genuine progesterone creams in which it is usually identified as "wild yam extract". However there is usually not enough diosgenin in these creams to have much of an effect. Thus, many women using a wild yam cream have stated that they just don't seem to feel any change. Most of the research that has been done on progesterone demonstrates that it is supplemental natural progesterone that will produce an increase in saliva and serum levels of progesterone, not yam extract.

   There has been considerable "hype" about all of the potential health benefits of progesterone cream applied to the skin. Here is what the medical scientific studies using randomized clinical trials show:

   Hot flashes have been shown to be significantly improved by use of progesterone cream but osteoporosis may not be being prevented at doses commonly used.

   If you are taking estrogen replacement after the menopause, progesterone cream does not protect the uterine lining (endometrium) from risk of cancer.

   Progesterone is definitely absorbed into the blood stream by skin cream applications but blood level and saliva measurement of progesterone is not reliable due to the variable levels absorbed. Saliva levels are much higher than blood levels

   Who should use progesterone topical skin cream?

   Women who have had a hysterectomy and have undergone natural or surgical menopause who do not wish to take estrogen replacement but who are having problems with hot flashes

   Women who have not had the uterus removed but have undergone natural menopause and do not wish to take any estrogen replacement

   Women who are perimenopausal who are not taking prescription estrogens or birth control pills but who are having hot flashes and wish some relief

   All women who use topical skin progesterone cream should still take supplemental calcium (1000-1500 mg a day) to help prevent osteoporosis.

   How to use

   Each teaspoon contains 80 mg of progesterone. The studies on hot flashes showed significant reduction at 20 mg a day. Therefore the dose each day should be about 1/4 teaspoon of cream rubbed on the skin. Dr. Rick Jelovsek recommends using the cream on a daily basis rather than cyclical use as recommended by others.

   Self-Dosing

   Feelgood2000?Natural Progesterone cream is easily and quickly absorbed into the body so you can apply it almost anywhere with success.

   We recommend that you rotate the areas you apply it, to avoid saturating any one area. It is best absorbed where the skin is relatively thin and well supplied with capillary blood flow, such as the face, neck, upper chest, breasts, inner arms and inner thighs and wrists.

   Apply and massage into your skin until it is noticeably absorbed. Natural progesterone cream should not be applied over top of other body creams or perfumes as this may interfere with proper absorption.

   Ingredients
   Natural Progesterone: (USP 2%) Pharmaceutical Grade (550 mg. per oz. 1650 mg per tube).
   Diosgenin: 400 mg. per oz derived from the Wild Yam Extract.
   Red Clover Extract: 400 mg. per oz. 1200mg. per tube
   Siberian Ginseng Extract
   Cetyl Acetate (and) Acetylated Lanolin Alcohol, Deionized Water, Caprylic Triglycerides, Glyceryl Stearate and Octal Palmitate

   For Absorbsion Efficacy: Carbomer, Glycerine, Stearic Acid and Dimethicone.


   Scientific References:
    
    1.Diosgenin--a growth stimulator of mammary gland of ovariectomized mouse.Aradhana, Rao AR, Kale RK.Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
    2.Usages of Diosgenin from Wild Yam.Via Michael Derrida.

   Amanuensis&Symbol trace Calligrapher: Michael Derrida