What is Pilose asiabell root,Poor Man's Ginseng?

Functionality and Application of Radix Codonopsis Pilosulae.

Pilose Asiabell Root Extract Radix Codonopsis Pilosulae Codonopsis Pilosula Franch Nannf Pilose asiabell root Dang Shen Ginseng Yellow Ginseng Moderate Asiabell Root photo picture image Dosage Suggestions:

Most practitioners recommend a codonopsis decoction between 3-9 grams depending on the condition being treated. Other conditions may require dosages as high as 30 grams per day.The raw herb is appropriate for promoting body fluid production to help nourish the blood. The processed herb is suitable for invigorating the spleen to benefit the lungs.

Decoction: 6 to15g is orally taken. The herb can be made into pills, powder, or paste.
5:1 concentrated extract: 1.2 to 3g/day.

Safety and Acute Toxicity:LD50 for intra-abdominal injection of Dang Shen polysaccharides is 2.06+-0.28g/kg.

Precautions:Patients with excess and heat syndromes should be prohibited from taking the drug. It is appropriate for the herb to be used alone for patients with body resistance weakened while pathogenic factors prevail.

Clinical Trials

Clinical and experimental study on codonopsis pilosula oral liquor in treating coronary heart disease with blood stasis:

The effects of Codonopsis pilosula on plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of 25 patients of coronary heart disease with blood stasis showed significant decrease in t-PA activity and platelet aggregation with no significant difference in t-PA and PAI.

The effects of Codonopsis pilosula oral liquor (CPOL) on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of 25 patients of coronary heart disease with blood stasis were studied. It has been shown that those patients had a significant decrease in t-PA activity (P less than 0.01) compared to healthy subjects. After 4 weeks of CPOL therapy, platelet aggregation significantly decreased (P less than 0.05), there was no significant difference in t-PA and PAI. From the results shown above, it suggested that one of the effects of CPOL in influencing blood coagulation was its inhibition on platelet aggregation, but not through the elevating of fibrinolytic activity.

Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B

This paper reports that 320 patients with chronic hepatitis B treated with YGNG (Astragalus membranaceus , Artemisia capillaris, Codonopsis pilosula) had results at the 6 months follow up showing that 60 of 62 patients receiving YGNG were in stabilized state.

This paper reports that 320 patients with chronic hepatitis B (CHB) were treated with Yi-ganning Granule (YGNG) and the pharmacodynamics of YGNG in the animal study. As control, another 70 patients with CHB receiving oleanolic acid granule (OAG) were compared to 68 patients in YGNG group. YGNG is consisted of Astragalus membranaceus , Artemisia capillaris, Codonopsis pilosula, et al. Each patient has taken YGNG or OAG for 3 months. The result showed YGNG was effective on recovering the liver function and OAG had similar effect. The sero-negative conversion rates of HBsAg, HBeAg, HBcAb and positive conversion rate of HBeAb in the YGNG group were 33.1%, 40.5%, 10.5% and 15.5% respectively, which were much better than that in OAG group (P less than 0.05-0.001). The result of 6 months follow up showed that 60 of 62 patients receiving YGNG were in stabilized state. The result in the animal study demonstrated that YGNG had significant protection from the liver damage caused by CCl4. YGNG could decrease serum ALT level and protect the liver function of carbohydrate, fat, protein metabolism and detoxication. YGNG could induce interferon in vivo and play an important role in seroconversion of negative DHBV-DNA and improvement of pathological morphology in viral hepatitis B.

Immunological and hematopoietic effect of Codonopsis pilosula on cancer patients during radiotherapy

Codonopsis pilosula was used as an adjuvant in 76 cancer patients during radiotherapy and its protective effect on hematopoietic and immunologic function was studied. Results: (1) No influence on Hb and WBC of the patients with radiotherapy. (2) It could reduce the immunosuppressive effect of radiotherapy on delayed hypersensitive reaction, the lymphocyte response to PHA and IL-2. (3) No difference between treated and control groups in most humoral immune indices such as IgG, IgA and C3, but had slight increase in IgM in treated patients, while significant decrease in control.

Treatment of operated late gastric carcinoma with prescription of strengthening the patient's resistance and dispelling the invading evil in combination with chemotherapy: follow-up study of 158 patients and experimental study in animals

158 cases of late gastric carcinoma (11 males and 47 females, age 30-70 years) were treated postoperatively with TCM prescriptions of strengthening the patient's resistance and dispelling the invading evil in combination with chemotherapy. The main ingredients were Radix Codonopsis Pilosulae, Radix Astragali seu Hedysari, Rhizoma Atractylodes, Herba Solani Hyrati, Herba Oldenlandiae and Herba Salviae. The prescription was individualized by adding or subtracting some herbs according to TCM syndrome diagnosis at the time of patient's visit. The decoction was given daily for a long time, three to four years or even longer. It was given alone or together with regimes of chemotherapy at random. The average survival rates at 3 and 5 years were 41.07% and 30.36% respectively. Seven patients have lived for more than 11 years. 10 years survival rate was 12.5%. The combination of Chinese medicine with chemotherapy was better than chemotherapy regime alone (single 5-Fu or CCNU+5-Fu, MMF). Immunological studies of the survivors revealed an enhancement of both humoral and cellular immunity especially the function of peripheral NK cells. The decoction had been given to mice bearing Ehrlich ascites tumor. The amount of ascitic fluid was reduced and its cancer cell count decreased besides a significant increase in over-all survival rate of the animals. It suggested that the above prescription might have an inhibitory or even killing effect on tumor cells. T cell immunity of the treated mice was also improved as seen among patients.

Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases

This paper reports the clinical treatment of 100 patients with minimal brain dysfunction (MBD), their age ranged from 7-14.2 years, and the average age was 10.5. Patients were divided into TCM and WM group randomly. The TCM group (80 cases) were treated with the therapy of subdueing hyperactivity of the Liver and invigorating the function of the Spleen by using: Bupleurum chinense, Scutellaria baicalensis, Astragalus membranaceus, Codonopsis pilosula, Ligustrum lucidum, Lophatherum gracile and thread of ivory. The WM group (20 cases) were treated with retalin 5-15 mg twice daily. One course of treatment lasted one month, and effects were evaluated after 1-3 courses of treatment. The results were as follows: In the TCM group, 23 cases were cured (clinical symptom and sign disappeared, 10 IQ units were raised in their intelligence, abnormal electroencephalogram was recovered and there was no recurrence during the first six months after recovery). 46 cases were improved (clinical symptom and sign markedly improved, 4 IQ units raised in intelligence and electroencephalogram improved), and 11 cases ineffective. The effective rate was 86.25%. In the WM group, 6 cases were cured, 12 cases improved and 2 cases ineffective, the clinical effective rate being 90.0%. There was no significant difference between the two groups in this study, but, the side-effects of the TCM group was less than the WM group, and the TCM group had more beneficial effects to improve intelligence, enuresis and the black of orbits. The study showed that the Verbal Scale in Wechsler Intelligence Scale for children is one of the indications of diagnosis and evaluating of the curative effect of MBD.

A clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction

This paper deals with the prospective clinical study on treatment of acute upper digestive tract hemorrhage with Wen-She decoction (WSD). An opened sequential controlled trial method of simple orientation quality reaction was adopted in this study. 7 cases were treated and all of them were cured. It was concluded that WSD was an excellent therapy to treat the middle or small amount hemorrhage of acute upper digestive tract. The effective rate of WSD of the stool OB (+) becoming (-) within 5 days was more than 95%. WSD consists of Codonopsis pilosulae, Atractylodes macrocephala, Poria cocos, Glycyrrhiza uralensis, Zingiber officinale, Os sepiae Halloysitum rubrum and Astragalus membranaceus. It is effective in stopping bleeding by warming the Spleen and tonifying Qi.