Gentian root.Gentiana Lutea.Chinese Gentian.

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Suggestion and Administration of Gentian.Radix Gentianae.Gentian root.

Gentian Extract INCI Name Gentiana Lutea Extract EINECS ELINCS No 277-139-0 CAS 72968-42-4 photo picture image Combinitions:Combines with lemon and ginger.

 Preparation and Dosage:Gentian is best consumed in the form of a decoction (boiling 1 teaspoonful of powdered root in a covered container of about 2 pints of water for about 20 minutes).

 Daily dosage:Decoction 3-6g or pill can be orally taken.Tincture: 1 - 3 g; Fluidextract: 2 - 4 g; Root: 2 - 4 g. Mode of Administration: Comminuted drug and dried extracts for infusions, bitter-tasting forms of medications for oral administration.

 Tincture - 1:5 in 45% alcohol. Dose: Take 2-5 drops with water before meals.

 As a simple bitter, Gentian is considered more palatable combined with an aromatic, and for this purpose orange peel is frequently used. A tincture made with 2 OZ. of the root, 1 OZ. of dried orange peel, and 1/2 oz. bruised cardamom seeds in a quart of brandy is an excellent stomachic tonic, and is efficacious in restoring appetite and promoting digestion. A favourite form in which Gentian has been administered in country remedies is as an ingredient in the so-called Stockton bitters, in which Gentian and the root of Sweet Flag play the principal part.
 The dose of the fluid extract is 1/2 to 1 teaspoonful in water, three times daily.

 Preparations and Dosages:Fluid extract, ? to 1 drachm. Compound infusion, B.P. 0.5 to 1 oz. Compound tincture, B.P. and U.S.P.,0.5 to 1 drachm. Solid extract, B.P., 2 to 8 grains.

 Root-G.Lutea:

 Fresh Gentian root is largely used in Germany and Switzerland for the production of an alcoholic beverage. The roots are cut, macerated with water, fermented and distilled; the distillate contains alcohol and a trace of volatile oil, which imparts to it a characteristic odour and taste.
 Decoction:use 10 g herb to 500 ml water and decoct for 20 minutes. Take before meals for fullness and stomach pains.

 Tincture:take up to 2 ml three times a day as a digestive stimulant, or in drop doses to allay cravings for sweet foods. Prescribed for liver disease, including hepatitis, gall bladder inflammations, and where jaundice is a symptom.

 Contraindication:Spleen and stomach deficiencies.
 Gentian Extract INCI Name Gentiana Lutea Extract EINECS ELINCS No 277-139-0 CAS 72968-42-4 photo picture image

 Acute toxicity:Gentianine
 LD50.Lethal dose,50 percent kill.Rodent-mice.Endogastric perfusion.460mg/kg
 LD50.Lethal dose,50 percent kill.Rodent-mice.Abdominal injection.350mg/kg
 LD50.Lethal dose,50 percent kill.Rodent-mice.Subcutaneous injection.>500mg/kg
 LD50.Lethal dose,50 percent kill.Rodent-mice.IV injection.250~300mg/kg

 Acute toxicity:Gentianidine

 LD50.Lethal dose,50 percent kill.Rodent-mice.Endogastric perfusion.1.25g(1250 mgs)/kg

 King's 1898 Dispensatory:

 'A powerful tonic, improves the appetite, strengthens digestion, gives more force to the circulation, and slightly elevates the heat of the body.'

 'When taken in large doses it is apt to oppress the stomach, irritate the bowels, and even produces nausea and vomiting, as well as fullness of pulse and headache. Its administration is contraindicated where gastric irritability or inflammation are present.'

 'Used in cases of debility and exhaustion, and in all cases where a tonic is required, as dyspepsia, gout, amenorrhoea, hysteria, scrofula, intermittents, diarrhoea, worms, etc.'

 'A tincture made by percolation of 1 part of podophyllum and 5 parts of gentian, diluted alcohol being the menstruum, was prized by Prof. Scudder as one of the most efficient remedies for 'atony of the stomach and bowels with feeble or slow digestion' (Spec. Med.).'

 'Gentian is valuable to relieve irritation and increase the appetite, after protracted fevers, where the powers of life are depressed and recovery depends upon ability to assimilate food.'

 'Dose of the powder, from 10 to 30 grains; of the extract, from 1 to 10 grains; of infusion, 1 or 2 fluid ounces; of tincture, 1 or 2 fluid drachms; of specific gentiana, 5 to 40 drops.'

 American Materia Medica, 1919 (Ellingwood):

 'This is a popular stomachic tonic in cases where enfeeblement has occurred as the result of protracted disease. It has long been given in combination with other tonics or in wine, as an agent in the dyspepsia of the aged, or of gouty patients, and in the gastric inefficiency of infants and children, and to a good advantage in catarrhal diarrhoea.'

 'As a tonic to the stomach, and the other organs of digestion and appropriation, in those cases where the system is greatly debilitated by protracted disease, it is one of the best remedies, especially by exhausting fevers of malarial origin. It is of much value in malarial conditions generally and has been used to a great extent instead of quinine.'

 'When the periodicity has been overcome by quinine this is a rapid restorative to the system.'

 'The tincture of gentian is given freely in conjunction with other tonics and with alteratives. It is given with the tincture of iron in the treatment of anemia complicating malarial disease. It is given in conjunction with the iodide of potassium where a tonic and alterative is demanded, and given alternately with hydrocyanic or hydrochloric acid, it is sometimes of great value in the vomiting of pregnancy.'

 'This agent is perhaps the most valuable of this class. It can be depended upon as a bitter tonic and constant use will establish a confidence in it.'

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Reference:

citations1.Gentian root.Gentiana Lutea.Chinese Gentian.

last edit date:19th,May.2009.