Nettle.Stinging nettle,Nettle leaf,Nettle root,Common Stinging Nettle?Therapeutics and Pharmacology,Historical or traditional use of Nettle.

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Nettle Pharmacology:Cell proliferation inhibition.

Nettle Extract INCI Name Urtica Dioica Extract EINECS ELINCS No 281-685-5 CAS 84012-40-8 Urticae radix Extracts Nettle Root Extract photo picture image Urtica dioica directly inhibited cell proliferation and the binding of epidermal growth factor to its receptor in a tumor cell line. Subfractions of an aqueous ethanolic stinging nettle root extract inhibited growth of BPH-tissue in vitro; a methanolic extract suppressed proliferation of BPH-tissue ex vivo. This activity may contribute to anti-inflammatory and antiprostatic activity of the extracts. The polysaccharide fraction, of the 20% methanolic extract of stinging nettle roots, was able to reduce the induced growth of prostate gland by 33.8% in mice. Chronic intraperitoneal administration of Bazoton solution at a dose of 20mg per kilogram daily in male rats for 10 days had induced a reduction of prostate weight. A reduction of biological activity in prostate cells was noticed by fluorescent microscopy under the effect of extract of Radix urticae (ERU)-Bazoton in patients with benign prostatic hypertrophy.

 Interaction with sex hormone binding globulin (SHBG):SHBG appears to play a role in the regulation of prostate cells. A hydroethanolic root extract and a methanolic root extract interfered with the binding of dihydrotestosterone (DHT) with SHBG. An aqueous extract was able to inhibit the binding of SHBG to receptors on the membrane of human prostate cells.

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citations1.Nettle.Stinging nettle,Nettle leaf,Nettle root,Common Stinging Nettle?Therapeutics and Pharmacology,Historical or traditional use of Nettle.

last edit date:22th,May.2009.