Grapefruit and GSE.Function and Application of Grapefruit seed extract.
- Botanical Basic Data of Grapefruit.
- Origin and Distribution of Grapefruit and Grapefruit Seeds?.
- Grapefruit Extract: What is GSE?.
- Production and processing of Grapefruit Extract.
- Function and Application of Grapefruit seed extracts.
- Dosage,Safety and additional comments of GSE?.
- Application of GSE in Pure Dish Wash?.
- External Application of GSE.
- Household uses of GSE.
- Function and Application GSE in slim formula.
- New, artificial grapefruit odorants.
- Frequently asked questions of GSE.
- Introduction of Naringin: Grapefruit's Fat Burning Accelerator.
- How Search Engine think about Grapefruit.
- Grapefruit Seed Extract Applications.
- Research Update:Grapefruit Seed Extract.
Dosage,Safety and additional comments of GSE?:
How long can I safely take grapefruit extract?
Grapefruit extract is not like pharmaceutical antibiotics where a set number of days treatment is specified. You can safely take GSE over a long period, if needed, without any worry of toxicity. We have reports of people taking GSE every day for years(as a preventative) without side-effects of any kind. Also, a long-standing parasite infection could take quite some time to overcome. Don't give up!
"I'm taking medication for high blood-pressure. Will GSE interfere?"
We have no reports of any drug interactions or contraindications of any kind. There is a danger in drinking fresh grapefruit juice or eating grapefruits when taking certain medications(consult your doctor). Grapefruit extract contains 0.1% or less of the compounds that increase absorption of certain medications. Consult your physician.
Why haven't I heard about grapefruit extract(GSE) before?
Most of our advertising is by word-of-mouth. Until the USFDA registration is approved, we cannot label the products as 'antimicrobial' or 'germicidal'. And consumers are overwhelmed with information from Drug companies and doctors who have little or no interest in botanical remedies. (BTW, We really appreciate hearing from you about your experiences with GSE.)
Is GSE made from the seeds and pulp of grapefruit?
Yes. Originally made from seeds only, it was discovered that a reasonable amount of the same active ingredient could be extracted from the pulp, also.
How do I use the powder concentrate of GSE?
For measuring accuracy in small doses, we recommend using the liquid concentrate. 1/16 teaspoon of powder concentrate is equivalent to 10-12 drops of Nutribiotic liquid(or 3-4 drops of Citricidal? professional strength), the recommended adult dose. So, generally speaking, just a small pinch at a time for various applications is plenty. This would be a handy way to add a little GSE to the washing machine, batch of potting soil, or wherever a dry preservative agent is needed. Our powdered extract is a very fine mesh powder that will mix well with any dry ingredients, including protein powders, corn starch, body powders, etc. The drying agent in Citricidal? Powder GSE is an inert, insoluble compound called silicon dioxide.
(Much of the powder concentrate being sold is going to manufacturers of encapsulated products, cosmetics makers, and those who are adding it to animal feed of various types.)
What is the 'shelf-life' of products containing grapefruit extract?
The oldest batch of extract still on hand is six years old, but it tests every bit as potent as a current batch. GSE is extremely stable. None of the NutriBiotic line(dental gel, cleansers, etc.) require a "best if used by..." date. The products will remain stable for an indefinite period, as long as they are not contaminated in some way.
Has GSE been tested?
Yes. View the partial list of labs that have tested GSE.Test results showing "Minimum Inhibitory Concentrations" and other stats are available upon request, and are now posted on the net. Most of our bulk-order customers have done their own lab testing to be sure of product potency and purity. In June 2002, 'The Journal of Alternative and Complementary Medicine' published research conducted by John Heggers, PhD, at the University of Texas Med School. This preliminary research confirmed that GSE was effective in inhibiting the growth of 67 different pathogens at dilutions that were non-toxic. Dr. Heggers plans further research on GSE as a wound dressing, as he is also affiliated with the Shriner's Hospital Burn Center in Galveston, TX.
In 1996 the U.S. FDA inspected the manufacturing facility in California, USA, and found no reason to change anything we were doing, including packaging, labeling, and manufacturing. Citricidal was submitted for official registration with the FDA as a "food and cosmetic additive", but FDA did not review the petition for two solid years. That petition was thereby terminated, and application has been made to the US Environmental Protection Agency(EPA) for registration as a water treatment. In 2000, the FDA was again petitioned to register Citricidal, but there has been no response. Don't hold your breath...
Which diseases will it cure?
Citricidal has been tested and found effective in lab studies against hundreds of pathogens, but we cannot guarantee a cure for anything. And we're not claiming that GSE works for everyone, everytime. There are countless herbal, homeopathic, and allopathic remedies that may be indicated. Still, GSE continues to be the "swiss-army-knife" of both prevention and cure.
GSE has been shown to be non-toxic at levels many times greater than the recommended dosages. Even when taken daily, GSE seldom produces a significant allergic reaction. However, people who are allergic to citrus fruits should exercise caution in the use of GSE.
Citricidal, the brand name of a GSE product in the United States containing 60% grapefruit seed extract in an aqueous, vegetable glycerine solution, has, in the United States, been labeled as GRAS (Generally Recognized as Safe) in the Code of Regulations. The Food and Drug Administration (FDA) has approved Citricidal? for cosmetic preparations. In addition, Citricidal? has also been approved by the FDA for the disinfection of foods.
Generally, GSE should never be used at full strength. GSE is extremely irritating to the eyes. If it gets into the eyes, a person should wash the eyes with large amounts of warm water and consult a physician, if necessary.
After an excessive ingestion of GSE, an individual should drink large amounts of water and take up to 3 tsp of psyllium husks (or up to 6 psyllium capsules). A doctor should be consulted, if necessary.
Side effectsSince GSE is quite acidic, if it is not properly diluted, it may further irritate already irritated tissues, such as a stomach or intestinal lining.
Interactions:Over 75 different combination herbal preparations containing GSE are available, based on the assumption of Chinese herbal medicine that combinations of substances are more beneficial than single remedies. In addition, the antimicrobial properties of GSE make it an excellent preservative, thus enabling the herbs it accompanies to retain their potency.
Safety and Toxicity of Grapefruit Seed Extract.:What are the risks to you in using grapefruit extract in your immune defense?
Acute oral toxicity:Lethal dose for fifty percent of tested organisms (LD50): greater than 5000 mg./kg of live weight.
Chronic toxicity:Lethal dose for fifty percent of tested organisms (LD50): 2500 mg/kg of live weight.(Acute oral with continuous feeding and reproduction study for 24 months.)
Acute Oral Toxicity:(Continuous feeding study with fishmeal for 12 mo's) LD50: 5000 mg/kg of live body weight(Adult rats, 12 months): LD50 400 mg/kg of live weight (newborn rats)
Carcinogencity:12-month tests in mice show no carcinogenic effect. 24-month tests in rats show no carcinogenic effect.
Eye toxicity:Eye IrritationIrritation has been observed at concentrations between 0.5-2%. Slight corneal and iris injury has been seen at full strength. Full strength - severe irritation with slight corneal iris injury. 0.5%, 1%, and 2% concentrations produce irritation and moderate erythema.
Respiratory toxicity:No damage was seen with 8 hours daily for five days a week over a period of 90 days with a dose between 100-150 mg/m3 of air.
Skin toxicity:Dermal ToxicityNot a primary skin irritant and is non-corrosive. Two years of exposure caused no carcinogenic, toxic or system effects with dermal exposure. No irritation is seen with 1-2% concentration exposures. Allergic persons may experience mild irritation with 3% concentrations.
GRAS:Products contain grapefruit extract have been recognized under the category of "generally recognized as safe."
Long-term Inhalation Study:Closed chamber exposure for 8 hours a day, 5 days a week for 90 days - no effect at 100 - 150 mg/m3 air Dermal Toxicity Carcinogenicity 2 year studies with rats and mice. No carcinogenic, toxicity or systemic effects seen.
Human Patch Studies:1% and 2% concentrations produced no irritation or sensitization. 3% concentration produced very mild irritation by allergic humans.
Safety and Toxicity of Naringin:
Chemical name: Naringin
CAS No.: 10236-47-2. Molecular Formula:C27-H32-O14. Molecular Weight:580.59
LD50-Lethal dose,50 percent kill. Intraperitoneal.Rodent-rat.2 gm(2000 mgs)/kg.
Details of toxic effects not reported other than lethal dose value.
LD50-Lethal dose,50 percent kill. Intraperitoneal.Rodent-guinea pig.2 gm(2000 mgs)/kg.
Details of toxic effects not reported other than lethal dose value.
Reference:EKMMA8 Eksperimentalna Meditsina i Morfologiya.(Hemus,Blvd.Russki 6,Sofia,Bulgaria)V.1-1962-Volume(issue)/page/year:19,207,1980.
Grapefruit Extract Safety Summary:
Grapefruit seed extract has been extensively tested and proven safe and effective by many laboratories and research centers throughout the world.
Grapefruit seed extract has no inherent toxicity and exhibits no negative impact on beneficial intestinal bacteria. There are no known side effects or interactions. Grapefruit seed extract can be taken for long periods of time with no ill or toxic effects.
It is non-allergenic. Even people who are allergic to citrus have had no adverse reactions. This is largely due to its harmonizing effects to cope with body stress. Although about 3 to 5 per cent of all people are allergic to citrus fruit and could therefore also display a sensitive reaction to grapefruit seed extract. These people should start with a low dosage and perform a patch test to be sure.
Grapefruit seed extract can be used safely by most people. Even infants and the elderly, as well as those with compromised health. Pets and animals of all types and sizes can benefit greatly using grapefruit seed extract.
Grapefruit seed extract has been safely used worldwide for over 25 years by countless doctors, alternative health care practitioners and veterinarians.
- 1.Grapefruit and GSE.Function and Application of Grapefruit seed extract.
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