Dosage and Safety of licorice root.
- Botanical Basic Data of Licorice.Glycyrrhiza Glabra.
- Narrative History and Description of licorice root.
- Phytochemicals and constituents of licorice root.
- Application and functionality of Licorice root.Glycyrrhiza Glabra.
- Therapeutics and Pharmacology:Glycyrrhiza from Licorice root stimulate endocrine system..
- Therapeutics and Pharmacology:super antibiotics,anti-inflammatory and anti-allergic,anti-arthritic.
- Nutrients,Uses,Acations and Indications of licorice root.
- Precautions and Possible Interactions of licorice root.
- Dosage and Safety of licorice root.
- Property and Applications of Licorice flavonoid.
- Estrogen of Licorice and Apply.
- How search engine think about Licorice.
- Research Update:Licorice.
Dosage and Safety of licorice root.
Dosage from various reference:
Dried root:1 to 5 g as an infusion or decoction three times per day
Licorice 1:5 tincture:2 to 5 mL three times per day
DGL extract:0.4 to 1.6 g three times per day for peptic ulcer
DGL extract 4:1: in chewable tablet form 300 to 400 mg 20 minutes before meals for peptic ulcer
A general medicinal dose is 1-2 cups of licorice tea a day. 1/2 to 1 teasp. of licorice root or powder is infused to 1 cup of boiling water. Tincture: 1/2 to 1 teasp. twice a day. For therapeutic use, it is recommended that licorice be taken before meals.
Dosage suggestions from CP:The CP(Chinese-Pharmacopia 2010) suggested the herb licorice nature smooth and taste sweet,enter into the heart,lung,spleen,stomach meridians.It main functions including invigorating spleen and replenishing qi,clear heat and resolve toxin,expelling phlegm and arresting coughing,relieving spasm and pain,moderating the property of herbs(coordinating the drug actions of a prescription).Indicated for weakness of the spleen and the stomach,fatigue and lack of strength,Palpitation and shortness of breath,cough with much sputum,pain in the stomach duct and abdomen,hypertonicity of the limbs,Carbuncle sore,smooth the toxicity and mildness of herbs.Suggested dosage 2 to 10grams.Contraindications it need avoid combine with seaweed,radix euphorbiae pekinensis,knoxia root,euphorbia kansui,flos genkwa,store at a dry and ventilated places,moth proofing.
Dosage suggestions from APA Guide:The APA Guide book suggested some commonly reported dosage:"A common-albeit conservative--dosage is 1 to 2 grams powdered root(Chinese sources commonly cite 2 to 12 grams,and European sources cite 5 to 15 grams),2 to 4 milliliters fluid extractmor 250 to 500 milligrams solid extract,three times per day.For premenstrual syndrome,licorice is taken two weeks prior to menstruation in the preceeding amounts.Licorice should not be taken for longer than four to six weeks.As an expectorant,a pinch of licorice is added to herbal teas.Take commercially prepared capsules according to package directions."2
Dosage suggestions from PDR Guide:The PDR Guide 4th edition suggested the licorice root "should not be administered for more than 4 to 6 weeks without medical advice.During this time,a high potassium diet should be consumed.Preparation:to prepare an infusion,use 1 to 1.5g of finely comminuted drug and add cold water.Bring to a boil,or pour the boiling water over the drug and allow to steep for 10 to 15 minutes and then strain(1 teaspoonful=3 gm drug).Daily Dosage:The average daily dose is 5 to 15 g of the root,equivalent to 200 to 600mg of glycyrrhizin.The drug is not to be taken longer than 6 weeks.Succus liquiritiae:"0.5 to 1 g for catarrhs of the upper respiratory tract and 1.5 to 3.0 g for gastric/doudenal ulcers.Tea:drink one cup of tea after meals."3
OverDosage:The intake of higher dosages(over 20grams per day for extract or over 50 grams per day for root)over an extended period of time will lead to hypokalemia,hypernatremia,edema,hypertension,and cardiac complaints.In rare cases,myoglobinemia has resulted due to the mineralcorticoid(aldosterone-like) effect of the saponins.Preparations from the drug should not be administered for longer than 6 weeks.The complaints disappear after discontinuing the drug.
Contraindications:The contraindications for licorice include chronic hepatitis,cholestatic diseases of the liver,cirrhosis of the liver,severe renal insufficiency,diabetes mellitus,hypertonic neuromuscular disorders,arrhythmias,hypertension,hypertonia,and hypokalemia.Tobacco use has been associated with licorice toxicity.Pregnancy:Not to be used during pregnancy.Breastfeeding:Not to be used during breastfeeding.
Safety and Toxicity of Licorice Root Component:
LD50: 2.52g/kg (mice/water-based extract/abdominal injection);
LD100: 3.6g/kg (mice/water-based extract/hypodermic injection).
Licorice Root Extract.LD50.Lethal dose,50 percent death.Oral.Rosent-mouse.>7500 mg/kg.
Licorice flavonoids.LD50.Lethal dose,50 percent death.Oral.Rodent-mouse.845 mg/kg
Chronic toxicity studies of Licorice flavonoids in dogs showed them to be devoid of any toxic effects on the heart, liver, kidney and other organs. They also did not cause any change in the levels of serum electrolytes (K+, Na+, and Cl-) as does glycyrrhizin.
Other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin:Not likely to cause skin irritation.
Eyes:Dust may cause mechanical eye irritation.
Inhalation:Dust may cause respiratory tract irritation.Breathing small amount of this material during normal handling is not likely to be harmful.
Ingestion:May cause gastrointestinal tract irritation with hypermotility and diarrhea.Swallowing this material during normal handling is not likely to be harmful.However swallowing large amount may be harmful.It may affect behavior/nervous system(muscle weakness,spastic paralysis,tetany,convulsions),heart,spleen.The toxicity is manifested primarily as hypokalemia.
Chronic Potential Health Effects:
Ingestion:Prolonged or repeated ingestion may affect the liver,and urinary system(kidneys) by binding to enzymes in the liver and kidney and alter the deactivation of glucocorticoids and other steriod hormones.It may also affect the blood,and metabolism(weight loss).
1: Licorice:Glycyrrhiza Glabra,Licorice Root Extract.
2: see The American Pharmaceutical Association Practical Guide to Natural Medicines,1st Ed.
3: see PDR for Herbal Medicines 4th Ed.
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