Licorice:Glycyrrhiza Glabra,Licorice Root Extract.

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Dosage and Safety of licorice root.

Licorice Root Extract INCI Name GLYCYRRHIZA GLABRA EXTRACT EINECS ELINCS No 283-895-2 CAS 84775-66-6 photo picture image Dosage:
 Dried root:1 to 5 g as an infusion or decoction three times per day
 Licorice 1:5 tincture:2 to 5 mL three times per day
 DGL extract:0.4 to 1.6 g three times per day for peptic ulcer
 DGL extract 4:1: in chewable tablet form 300 to 400 mg 20 minutes before meals for peptic ulcer

 A general medicinal dose is 1-2 cups of licorice tea a day. 1/2 to 1 teasp. of licorice root or powder is infused to 1 cup of boiling water. Tincture: 1/2 to 1 teasp. twice a day. For therapeutic use, it is recommended that licorice be taken before meals.

 Safety and Toxicity of Licorice Root Component:

 LD50: 2.52g/kg (mice/water-based extract/abdominal injection);
 LD100: 3.6g/kg (mice/water-based extract/hypodermic injection).
 Licorice Root Extract.LD50.Lethal dose,50 percent death.Oral.Rosent-mouse.>7500 mg/kg.
 Licorice flavonoids.LD50.Lethal dose,50 percent death.Oral.Rodent-mouse.845 mg/kg

 Chronic toxicity studies of Licorice flavonoids in dogs showed them to be devoid of any toxic effects on the heart, liver, kidney and other organs. They also did not cause any change in the levels of serum electrolytes (K+, Na+, and Cl-) as does glycyrrhizin.

 Other Toxic Effects on Humans:

 Acute Potential Health Effects:
 Skin:Not likely to cause skin irritation.
 Eyes:Dust may cause mechanical eye irritation.

 Inhalation:Dust may cause respiratory tract irritation.Breathing small amount of this material during normal handling is not likely to be harmful.

 Ingestion:May cause gastrointestinal tract irritation with hypermotility and diarrhea.Swallowing this material during normal handling is not likely to be harmful.However swallowing large amount may be harmful.It may affect behavior/nervous system(muscle weakness,spastic paralysis,tetany,convulsions),heart,spleen.The toxicity is manifested primarily as hypokalemia.

 Chronic Potential Health Effects:

 Ingestion:Prolonged or repeated ingestion may affect the liver,and urinary system(kidneys) by binding to enzymes in the liver and kidney and alter the deactivation of glucocorticoids and other steriod hormones.It may also affect the blood,and metabolism(weight loss).

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Reference:

citations1.Licorice:Glycyrrhiza Glabra,Licorice Root Extract.

last edit date:22th,May.2009.