Celery Seed.Apium Graveolens Application and Pharmacology.

Safety and Administration of Celery Seed.Apium Graveolens.

Celery Seed Extract INCI Name Apium Graveolens Extract EINECS ELINCS No 289-668-4 CAS 89997-35-3 photo picture image Side effects, precautions, interactions:

Pregnant women should not use celery seed because it may uterine bleeding and cause muscle contractions in the uterus. People with active kidney inflammation should also avoid this herb. Active compounds in celery stems and seeds can cause the skin to become highly sensitive to UV rays. Do not apply the essential oil externally in bright sunshine, because bergapten in the seeds could increase photosensitivity. The volatile oil in quantity is toxic to the kidneys and so should not be used in kidney disorders. Allergic reactions are rare.

Caution: Apium should be avoided in pregnancy because it is a uterine stimulant. The volatile oil in quantity is toxic to the kidneys and so should not be used in kidney disorders. Allergic reactions are rare.

Precautions:

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain active substances that can trigger side effects and that can interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a practitioner knowledgeable in the field of botanical medicine.

Pregnant women should not use celery seed because it may uterine bleeding and cause muscle contractions in the uterus.
People with active kidney inflammation should also avoid this herb.

Although uncommon, allergic reactions (even anaphylaxis) to celery seed may develop in people who handle or ingest celery. In fact, some individuals who are allergic to birch pollen may also be allergic to celery seed.

Active compounds in celery stems and seeds can cause the skin to become highly sensitive to UV rays (called photodermatitis). For this reason, people taking celery seed should use sunscreen or sunblock lotions to protect their skin from the sun.

Celery seeds should not be taken from a garden packet. Most seeds sold for these purposes have been treated with chemicals and should not be taken internally.

Possible Interactions:

There are no known scientific reports of interactions between celery seed and conventional medications. However, given that celery seed is an herb with diuretic effects, people taking prescription diuretics (such as furosemide or hydrochlorothiazide) should not take this herb without first consulting a healthcare provider.

Similarly,celery contains properties that may thin the blood, thus making it somewhat of a concern to take with blood thinning medications such as warfarin or aspirin. If you take warfarin in particular you should not use celery seed without first consulting your healthcare provider.

Since the effects of celery extract have not been evaluated for safety in pregnancy, it is generally recommended that it not be used during pregnancy or lactation. No other contraindications are presently known. I would advise individuals taking the drug Coumadin (warfarin) to be closely monitored by their physician when starting to use celery extract. It is just a precautionary recommendation.

Can I take celery extract with conventional anti-inflammatory drugs?Yes. There does not seem to be any adverse interactions with conventional drugs.

Dosage:

Pediatric:There are no known scientific reports on the pediatric use of celery seed. Therefore, it is not currently recommended for medicinal purposes in children.

Adult:

Celery seed oil capsules or tablets: One to two capsules or tablets three times a day, as directed by your health care provider.

Celery seed extract: 1/4 to 1/2 tsp three times a day, or as directed by your health care provider. (Always take with plenty of juice or with water at mealtime, unless instructed otherwise.)

Whole celery seeds: Prepare a tea by pouring boiling water over one teaspoon (1 to 3 g) of freshly crushed seeds. Let it steep for 10 to 20 minutes before drinking. Drink three times a day.

Combinations:Apium combines well with Menyanthes and/or Guaiacum in rheumatic disease. The therapeutic action of Apium is potentiated by Taraxacum.

How much celery or celery extract should I take for high blood pressure?:My recommendation is to either consume 8 ribs of celery per day or take a celery extract standardized to contain 85% 3nB and other celery phthalides at a dosage of 75 to 150 mg twice daily.

What is the proper dosage and are their any side effects?

Over 100,000 people in Australia have now used this proprietary celery seed extract standardized at 85% phthalides without any reports of side effects. The current recommendations for joint and muscle complaints based on the information now available from trials as well as clinical experience are the following (based upon using a celery seed extract standardized to contain 85% 3nB and other phthalides):

For the relief of join and muscle pain (including pain due to osteoarthritis, rheumatoid arthritis, and fibromyalgia): one tablet two to three times daily.

For gout: two tablets twice daily. NOTE: The initial blood uric acid measurements may increase in people with gout as uric acid crystals begin to dissolve.

Do you have to take the celery extract continuously to maintain benefits in relieving joint and muscle pain?

Yes. Results from the studies conducted to date indicate that as long as the celery extract is used it keeps pain at bay. But, if it is stopped the pain tends to recur.
Celery Seed Extract INCI Name Apium Graveolens Extract EINECS ELINCS No 289-668-4 CAS 89997-35-3 photo picture image

Toxicity and Safety:

Substance:Apigenin.

Chemical Name:Flavone,4'-5,7-trihydroxy-. CAS.No.520-36-5. Beilstein.No.0262620.
Molecular Formula.C15-H10-O5. Molecular Weight.270.25

Synonyms:Apigenin,Apigenine,Apigenol;4H-1-Benzopyran-4-one,5,-7-dihydroxy-2-(4-hydroxyphenyl)-;Chamomile;C.I.Natural Yellow 1;2-(p-Hydroxyphenyl)-5,7-dihydroxychromone;4',5,7-Trihydroxyflavaone;4',5,7-Trihydroxyflavone.

Acute Toxicity:LD50.Intraperitoneal.Rodent-mice.150mg/kg.LD50.Intraperitoneal.Rodent-rat.125mg/kg.

Mutagenic Data:
Mutation in microorganisms.Bacteria-Salmonella typhimurium.100 ug/plate.
Reference:BCSTB5 Biochemical Society Transactions.(Biochemical Soc.Book Depot,POB 32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1973-Volume(issue)/page/year:5,1489,1977.
Micronucleus test.Human Lymphocyte.5 mg/L.
Sister chromatid exchange.Human Lymphocyte.10 mg/L.
Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB211,1000AE Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:246,205,1991.

Substance:Celery Oil.Celery Seed Oil.RTECS:RJ3690450;CAS.No.8015-90-5.

Acute Toxicity:Oral.Rodent-rat.LD50.>5000 mgs/kg.

Reference:

1.Celery Seed.Apium Graveolens Application and Pharmacology.

last edit date:1st,Mar.2010.

Available Product

Name:Celery Seed Extract
Serie No:R002.
Specifications:10:1.5:1TLC.
INCI Name:APIUM GRAVEOLENS EXTRACT
EINECS/ELINCS No.:289-668-4
CAS:89997-35-3
Chem/IUPAC Name:Apium Graveolens Extract is an extract of the herb, roots and seeds of the celery,Apium graveolens,Umbelliferae

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