Research Update of Eyebright:Euphrasia officinalis.

  seminal trace...Eyebright Extract.5:1.Euphrasia extract.CAS.RN.NO:84625-36-5.Euphrasia officinalis L.Synonyms:Euphrasia Officinalis Extract,Extract of euphrasia,Eyebright Extract.....

 


   Phytochemical info of Eyebright Extract:

 Product Name:
 Synonym:
 Definition:Eyebright Extract are majorly composed of
 Chemical information disclosed as following table:


   Research Update of Eyebright:Euphrasia officinalis

  Recent Positive Clinical Findings:

 The aim of a recent human prospective cohort trial (Stoss et al. 2000) was to describe the efficacy and tolerability of Euphrasia eye drops in a community-based setting. The trial was carried out in the clinics of 12 experienced general practitioners and ophthalmologists in Germany and Switzerland. Patients with inflammatory or catarrhal conjunctivitis, treated with Euphrasia single-dose eye drops were included in the trial. One drop of Euphrasia single-dose eye drops 1-5 times a day was prescribed. The prescription was determined solely by medical therapeutic needs. The measures of efficacy were determined by assessing: redness, swelling, secretion, burning of the conjunctiva, and foreign body sensation. Tolerability variables were: conjunctival reddening, burning of the conjunctiva, foreign body sensation, and veiled vision. All symptoms were given for the right or left eye separately, with degree of severity in relation to baseline after approximately 7 days and after approximately 14 days. If, after the first follow-up, all symptoms had disappeared, no second follow-up was done. Sixty-five (65) patients fulfilled the inclusion criteria for the protocol evaluation. A complete recovery was seen in 53 patients (81.5%) and a clear improvement in 11 patients (17.0%). A slight worsening could only be determined in 1 patient in the second week of treatment (1.5%). No serious adverse events were observed during the entire trial. The efficacy and tolerability of the eyebright eye drops were evaluated by the patients and doctors and were deemed as "good" to "very good" in more than 85% of cases. The researchers concluded that Euphrasia single-dose eye drops can effectively and safely be used for various conjunctival conditions by general practitioners and ophthalmologists. A dosage of one drop three times a day seems to be the general prescribed dosage. [Stoss M, Michels C, Peter E, Beutke R, Gorter RW. 2000. Prospective cohort trial of Euphrasia single-dose eye drops in conjunctivitis. J Altern Complement Med. Dec; 6(6): 499-508].

  Review of complementary and alternative medicine in treatment of ocular allergies.:Curr Opin Allergy Clin Immunol. 2003 Oct;3(5):395-9.Bielory L, Heimall J.Department of Medicine, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA. bielory@umdnj.edu.

 PURPOSE OF REVIEW: Ocular allergy is a common complaint of allergy sufferers, many of whom may choose to use complementary and alternative medicine in the treatment of these symptoms. In this review major complementary and alternative medicine modalities including herbal therapies, acupuncture, homeopathy, alternative immunotherapy and behavior modification are assessed for evidence of their effectiveness in the treatment of ocular allergy symptoms. RECENT FINDINGS: Certain herbs including Euphrasia officinalis, Petasites hybridus and Argemone mexicana have been evaluated in control studies in the treatment of ocular allergy. Honey is no more effective than placebo in the treatment of ocular allergy. Acupuncture used regularly has demonstrated some positive trends in ocular allergy sufferers. Homeopathy has shown conflicting results in the treatment of ocular allergy, while alternative forms of immunotherapy have been shown to develop immunologic tolerogenic effects in the control of the condition. SUMMARY: Several forms of complementary and alternative medicine have been studied for their effectiveness in treatment of ocular allergy symptoms. Further research is needed to assess mechanisms of action and to establish practice guidelines for the use of these modalities

  In vitro anti-mycotic activity of some medicinal plants containing flavonoids.:Boll Chim Farm. 2000 Sep-Oct;139(5):225-7.Trovato A, Monforte MT, Forestieri AM, Pizzimenti F.Pharmaco-Biological Department, School of Pharmacy, Vill. SS. Annunziata, 98168 Messina.

 Aqueous, ethanolic and petroleum ether extracts of Citrus sinensis L. (Osbeck), Euphrasia officinalis L., Glycyrrhiza glabra L., Matricaria recutita L., Rosa canina L. and Ruta graveolens L. have been studied. The antimycotic activity was evaluated "in vitro" on strains of Candida albicans isolated from clinical samples obtained in the course of acute vaginitis.

  In vitro cytotoxic effect of some medicinal plants containing flavonoids.:Boll Chim Farm. 1996 Apr;135(4):263-6.Trovato A, Monforte MT, Rossitto A, Forestieri AM.Pharmaco-Biological Department, School of Pharmacy, Messina, Italy.

 Aqueous, ethanolic and petroleum ether extracts of Citrus sinensis L. (Osbeck), Euphrasia officinalis L., Glycyrrhiza glabra L., Matricaria recutita L., Rosa canina L. and Ruta graveolens L. have been studied. The cytotoxicity of the drugs assayed was evaluated "in vitro" by means of the dye test using cells of the Yoshida ascites sarcoma. The aqueous extract of Citrus sinensis L. (Osbeck); the petroleum ether extract of Glycyrrhiza glabra L.; the ethanolic and petroleum ether extracts of Rosa canina L. and the petroleum ether extract of Ruta graveolens L. showed a quite significative cytotoxic effect.

  Identification and determination of effective components in Euphrasia regelii by capillary zone electrophoresis.:Biomed Chromatogr. 2004 Dec;18(10):857-61.Shuya C, Shengda Q, Xingguo C, Zhide H.Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.

 A capillary zone electrophoresis (CZE) method has been developed for simultaneous determination of eukovoside, cinnamic acid and ferulic acid in Euphrasia regelii for the first time. The electrophoresis buffer was 20 mmol/L sodium borate containing 10% (v/v) methanol (pH 8.50). The effects of concentration of borate and electrolyte pH on electrophoretic behavior and separation were studied. Regression equations revealed linear relationships (correlation coefficients 0.9995-0.9998) between the peak area of each analyte and the concentration. The levels of analytes in the different parts of Euphrasia regelii were easily determined with recoveries ranging from 95.5 to 104.2%.


  Studies on the chemical constituents from the water-soluble part of Euphrasia regelii:Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):733-4.Li L, Wang HQ.Lanzhou Institute of Chemical Physics, Chinese Academy Sciences, Lanzhou 730000, Gansu, China.

 OBJECTIVE: To study the chemical constituents from the water-soluble part of Euphrasia regelii. METHOD: The compounds were isolated by macroporous resin and column chromatography, and identified by IR, NMR data. RESULT: Two special compounds were isolated and identified. CONCLUSION: Two compounds were isolated from this plant for the first time.

  Iridoid Glucosides from Euphrasia rostkoviana:Planta Med. 1983 Feb;47(2):90-4.Salama O, Sticher O.Eidgen?ssische Technische Hochschule Z¨¹rich, Pharmazeutisches Institut, Z¨¹rich, Schweiz.

 Eight iridoid glucosides have been isolated from EUPHRASIA ROSTKOVIANA by the combination of open column- and high performance liquid chromatography. The structure of a new compound, named eurostoside, and the identity of the others have been established by chemical transformations and spectral evidence of the compounds and their derivatives.


  Scientific References:

  1.Research Update of Eyebright:Euphrasia officinalis.
  2.Eyebright--just the Greek Euphrasia.Euphrosyne.Gladness.