Griffonia Seed and 5-HTP (5-hydroxy tryptophan),the magic seed from African folk medicine not only play as effective replacement for tryptophan,but more.

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Administration and Suggestions of 5-HTP.

Griffonia Seed Extract 5-Hydroxytryptophan 5HTP CAS 4350-09-8 photo picture image For Sleep: 100-600 mg within 1 hour before bedtime either with water or a small carbohydrate snack (but no protein) or one half of dose 1/2 hour before dinner and the rest at bedtime.
 For Daytime Calming: 1-2 of the 100 mg every few hours through the day until calming benefits felt.
 ALWAYS TAKE 5-HTP or TRYPTOPHAN with pyridoxal-5-phosphate to ensure adequate and proper conversion to serotonin rather than unwanted metabolites.

 Side effects are rare but may be: Raises Seratonin Levels,Nausea,Headache,"Hung over" feeling,Paradoxical agitation,Blood pressure increase only in those who already have high blood pressure of a fluctuating type.

 5HTP has been sold in the USA since 1994. Our understanding of the clinical benefit of 5HTP and its side effect profile is still fuzzy. We don't know as much as we should about the benefit of 5HTP and side effects of chronic 5HTP use. Therefore, until we learn more, the idea is to take 5HTP in the minimum effective dosage and to avoid its prolonged continuous use. Take breaks from the use of this nutrient to avoid potential 5HTP side effects (the frequency and length of breaks varies since each person is unique). As of 2007, and after more than a decade off 5HTP being available to the public, we are not aware of any reports in the medical literature of anyone who has encountered life threatening or other serious 5HTP side effects. Common side effects with 5HTP include nausea, stomach upset, loose stools or constipation, and headache.

 What is the best way to take 5-HTP?

 For depression, weight loss, headaches, and fibromyalgia the dosage should be started at 50 mg three times per day. If the response is inadequate after two weeks, increase the dosage to 100 mg three times per day. This recommendation will greatly reduce the mild symptoms of nausea often experienced during the first few weeks of 5-HTP therapy. Using enteric-coated capsules or tablets (pills prepared in a manner so that they will not dissolve in the stomach) significantly reduces the likelihood of nausea. Because 5-HTP does not rely on the same transport vehicle as L-tryptophan, it can also be taken with food. But, if you are taking 5-HTP for weight loss I recommend taking it 20 minutes before meals.

 For insomnia, I recommend 100 to 300 mg thirty to forty-five minutes before retiring. Start with the lower dose for at least three days before increasing dosage.

 Toxicity and Safety:5-hydroxy tryptophan

 Chemical Identification:
 Chemical Name:Tryptophan,5-hydroxy-. Cas.No.56-69-9 Molecular Formula:C11-H12-N2-O3. Molecular Weight:220.2.
 Synonyms:5-Htp;Hydroxytryptophan;5-Hydroxytryptophan;5-Hydroxytryptophane;5-Hydroxytrytophan;NCI-C56644;USAF CB-96.
 Solubility:Soluble in water. Handling:Protect from light. Appearance;White Solid.

 Acute Toxicity:
 LD50-lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.200 mg/kg.Details of toxici effects not reported other than lethal dose value.
 Reference:NTIS**National Technical Information Service.(Springfield,VA 22161).Formerly U.S.Clearinghouse for Scientific and Technical Information.Volume(issue)/page/year:AD277-689.

 Reproductive Data:
 TDLo-Lowest published toxic dose.Intraperitoneal.Rodent-rat.30 mg/kg.Sex/Duration:male 1 day(s) pre-mating.
 Toxic Effects:Reproductive-Fertility-mating performance (e.g.#sperm positive females per # females mated;#copulations per # estrus cycles)
 ANENAG Annales d'Endocrinologie.(Masson Editeur,120 Blvd.Saint-German,F-25280 Paris Codex 06,France) V.1-1939-Volume(issue)/page/year:24(Suppl 3),1,1963

 General Description:
 TOXICOLOGY REVIEW.CLPTAT Clinical Pharmacology and Therapeutics (St.Louis).(C.V.Mosby Co.,11830 Westline Industrial Dr.,St.Louis,MO 63146)V.1-1960-Volume(issue)/page/year:5,480,1964.

 Report in USA:
 EPA TSCA Section 8(b) CHEMICAL INVENTORY

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citations1.Griffonia Seed and 5-HTP (5-hydroxy tryptophan),the magic seed from African folk medicine not only play as effective replacement for tryptophan,but more.

last edit date:2nd,June.2009.