What is Picrorrhiza Root and it's major application?
- Basic Botanical Info of Picrorrhiza kurroa.
- Phytochemical and Constituents of Picrorrhiza Root.
- Indications of Picrorrhiza Root.
- Western Properties and Reported Uses.
- Action and Classical Note of Picrorrhiza Root.
- Picrorrhiza Root:Pharmacology.
- Dosage,Administrations and Safety.
- Application Case Study:Liver function improvement formulation.
- Research Update:Picrorrhiza kurroa and Picrorhiza scrophulariaeflora.
Dosage,Administrations and Safety.:
Adult Dosage Range:500mg - 2g/day or 400 to 1500 mg/day of the dried root.with doses up to 3.5 g/day sometimes being recommended for fevers.250mg (standardized extract), 2 to 4 times daily.Tincture: 2 to 4 ml daily.
Most Common Dosage:250mg (standardized extract), 2 times daily.Tincture: 2 ml daily.
1-4mL/day of 1:2 extract
Root powder:300 - 500 mg. b.i.d. / t.i.d. 2 - 3 weeks for viral hepatitis.1 - 2 gms. M.S. for laxative effect
Standardization:The most current available medical and scientific literature indicates that this dietary supplement should be standardized to 4%-10% kutkin.
3-4 gm of drug is generally given as antiperiodic and 0.6-1.2 gm as bitter tonic. Typical adult dosage is 400 to 1500 mg/day, with dosages up to 3.5 g/day sometimes being recommended for fevers
Between 400 and 1,500 mg of powdered, encapsulated picrorhiza per day has been recommended. One author considers this equivalent to the use of 1~!2 ml of fluid extract twice per day.Picrorhiza tastes quite bitter. Combining with ginger root powder capsules or taking as tea can improve palatability.
Side effects or interactions:
Loose stools and colic have been reported when unprepared picrorhiza rhizomes are used as medicine. However, extracts in alcohol have shown much less tendency to cause such effects.19 No other adverse effects have been reported with picrorhiza. Although the use of the herb is not discouraged in India during pregnancy and breast-feeding, there is little information to determine the safety of the herb during these times.
In sensitive individuals high doses may cause diarrhea,flatulence and griping (due to cucurbitacins),skin rash
Some people find the bitterness intolerable
Cautions Contraindicated in Spleen/Stomach Deficiency
Contraindicated in pregnancy
Toxicity Relatively safe for long term use
General:Picrorhiza is reported safe in recommended dosages.
Health Conditions:Based on pharmacology, use with caution in individuals with bleeding disorders.
Pregnancy/Breast-Feeding:If pregnant or nursing, consult a physician before use.
Age Limitations:Do not use in children under 2 years of age unless recommended by a physician.
Picrorhiza kurroa (P.kurroa), a known hepatoprotective plant, has been studied in experimental and clinical situations.In a randomised, double-blind placebo controlled trial in patients diagnosed to have acute viral hepatitis (HBsAg negative), P. kurroa root powder 375 mg three times a day was given for 2 weeks (n = 15) or a matching placebo (n = 18) was given. Difference in values of bilirubin, SGOT and SGPT was significant between placebo and P.kurroa groups. The time in days required for total serum bilirubin to drop to average value of 2.5 mg% was 75.9 days in placebo as against 27.44 days in P.kurroa group.
Toxicity and Safety:
Picrorhiza is generally regarded as safe when taken in the recommended doses; however, mild side effects such as loose stools and colic pains occur when unprepared Picrorhiza rhizomes are used.Picrorhiza is not readily water-soluble and is therefore not usually taken as a tea. While it is ethanol soluble, the bitter taste makes tinctures unpalatable, so it is therefore usually administered as a standardized (4% kutkin) encapsulated powder extract. Typical adult dosage is 400 to 1500 mg/day, with dosages up to 3.5 g/day sometimes being recommended for fevers. Picrorhiza root extracts are widely used with no adverse effects having been reported. Safety in young children or those with severe liver or kidney disease is not known. The [LD50] of kutkin is greater than 2600 mg/kg in rats with no data available for humans.
- 1.What is Picrorrhiza Root and it's major application?
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