Old ancient soybean,Soy and the dissemination,cultivation.

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Health and Functionality of Soy:6).Soy as Bowman-Birk inhibitor(BBI).

Soy Bean Extract INCI Name Glycine Soja Extract CAS 84776-91-0 Soy isoflavones Genistein CAS 446-72-0 Daidzein CAS 486-66-8 Glycine max L extract photo picture image Another health benefit of soy intake may be through inhibition of angiogenesis by a peptide found in many soy products, referred to as Bowman-Birk inhibitor (BBI). Angiogenesis is the formation of new blood vessels to supply blood and nutrients and to remove metabolic wastes from living tissue. Physiologic angiogenesis is a tightly regulated process important to embryonic development, reproduction and wound healing. Pathologic angiogenesis is a feature of many inflammatory diseases and contributes to the spread of several chronic diseases and may involve excessive or inadequate angiogenesis. Prevention of excessive angiogenesis involves using drugs that inhibit the enzymes required for new blood vessel formation. Stimulation of new blood vessel growth with growth factors is being considered for therapeutic treatment of insufficient angiogenesis for patients with poor wound healing of skin ulcers.

 Data from animal models and cell culture show that angiogenesis can be inhibited by naturally occurring physiologically active compounds, such as BBI. BBI is stable to gastrointestinal digestion and maintains biological activity even after boiling for 10 minutes. BBI is used in the soybean as a defense mechanism against insects, predators and bacterial and viral infections. BBI is a natural inhibitor of several metalloprotease enzymes that lead to the onset and progression of angiogenesis and diseases related to excess production of new blood vessels.

 LSU AgCenter research has shown that BBI at concentrations found in a cup of soymilk can completely prevent the activation of metalloproteinases by binding to the enzymes. These enzymes can be maintained in an inactive form by the presence of low concentrations of BBI. The prevention of metalloprotein-ase activation preserves the integrity of the basal membrane and other tissues and may delay the onset and progression of diabetes complications, periodontal diseases, cancer, arthritis, osteoporosis, psoriasis and AIDS complications. Because treatments for many of these conditions may be costly and ineffective, good nutrition may be the key to prevention. Two advantages for promoting BBI as an inhibitor of angiogenesis are 1) BBI is not perceived as a medicine and has no known side effects in Asian populations who have consumed soy products for generations and appear to have low rates of chronic diseases and 2) food fortification with soybean BBI would be a relatively inexpensive way to deliver BBI over a life pan.

 BBI is a protein with health-enhancing properties that encompass a wide range of human ailments. Consumption of soymilk by the general population may provide health benefits in the intestinal tract and should be encouraged. A cup of soymilk a day may help keep the doctor away.

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citations1.Old ancient soybean,Soy and the dissemination,cultivation.

last edit date:5th,June.2009.