What is the differenciation between Panax ginseng and Ginsengs,How to use Panax Ginseng,Chemistry and Pharmacology,Substitutes?

Contents

How to use Panax Ginseng: dosage,administration,precautions and combinations.:

Panax Ginseng Extract INCI Name Panax Ginseng Extract CAS 84650-12-4 EINECS ELINCS No 283-493-7 Radix Ginseng Extract Asian Ginseng Extract Ginsenosides Fructus Panax Ginseng Folium Panax Ginseng Radix Panax Ginseng photo picture image Combinations:

 Panax may be combined with Turnera and Serenoa in glandular weakness. In China, it is rarely used on its own, but is usually combined with liquorice or Chinese dates.

 Indications:

 Atherosclerosis, adrenal insufficiency, ageing, anemia, cancer, chronic illness, depression, diabetes, dyspepsia, effects of radiation, effects of morphine and cocaine use, encouraging proper hormonal function, fatigue, heart problems, hypertension, impotence, increasing energy, infertility, inflammation, improving abstract thinking, reaction times and mental awareness, improving lipid levels, improving nerve growth, increasing life expectancy, increasing resistance to disease, insomnia, internal degeneration, lowering cholesterol, mental wellbeing, nausea, nervousness, periodontal disease, physical wellbeing, poor memory, poor circulation, pseudomonas aeruginosa, pulmonary problems, relaxing the nervous system, regulating menses, shock, stress (environmental, physical and mental), stimulating appetite, tiredness, tumours, ulcers, vaginal dryness, viral infections, vomiting, weakness.

 Applications:

 1.To treat collapse due to qi deficiency with symptoms of paleness, cold sweating throughout the body and extremely faint pulse, tending to cease: ginseng can be used in its large dosage of concentrated decoction or in combinatioit with prepared aconite root for invigorating qi, recuperating depleted yang, rescue the patient from collapse, such as Shen Eu Decoction.

 2.To treat deficiency of qi and yin, perspiration, lassitude, vexation, thirst and faint pulse tending to cease: ginseng is often used in combination with ophiopogon root and schisandra fruit for invigorating qi, nourishing yin, astringing perspiration and treating collapse, such as Shengmai Powder.

 3.Invigorating qi and strengthening the spleen: Ginseng is often used in combination with white atractylodes rhizome, poria, liquorice and other herbs for invigorating qi and strengthening the spleen, such as Sijunzi Decoction, to treat deficiency of spleen-qi and stomach-qi, anorexia, emaciation, lassitude and loose stool; and with astragalus root, bupleurum root, cimicifuga rhizome and other herbs for invigorating qi and elevating yang, to treat sinking of qi in middle-jiao, lingering diarrhea, proctoptosis and splan chnoptosis.

 4.For tonifying the lung, arresting cough and alleviating asthma, to treat deficiency of the lung-qi, lingering cough and asthma of deficiency type, perspiration on exertion, lassitude and faint pulse: Ginseng is often used in combination with schisandra fruit, astragalus root, tatarian aster root and other herbs for tonifying the lung, arresting cough and alleviating asthma, to treat deficiency of the lung-qi, lingering cough and asthma of deficiency type, perspiration on exertion, lassitude and faint pulse; and with genko, walnut kernel, psoralea fruit and other herbs for improving inspiration and relieving asthma, to treat lingering cough and asthma of deficiency type due to failure of the kidney in holding air.

 5.For clearing heat and fire, invigorating qi and promoting yin (the production of the body fluid), to treat epidemic febrile disease caused by exopathogen, injury of qi and yin by heat, vexation, thirst, perspiration and lassitude: Ginseng is often used in combination with Baihu Decoction for clearing heat and fire, invigorating qi and promoting yin (the production of the body fluid), to treat epidemic febrile disease caused by exopathogen, injury of qi and yin by heat, vexation, thirst, perspiration and lassitude; and with dried rehmannia root , trichosanthes root, pueraria root and other herbs for promoting the production of the body fluid and quenching thirst, to treat interior heat and diabetes.

 6.To treat vexation, insomnia and amnesia caused by deficiency of qi and blood and irritability: To treat vexation, insomnia and amnesia caused by deficiency of qi and blood and irritability, ginseng is often used in combination with longenaril, wild jujube seed, Chinese angelica root and other herbs for nourishing the heart and tranquilizing the mind.
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 Side Effects:

 One of Panax ginseng's most common side-effects is the inability to sleep.Other side-effects include nausea, diarrhea, euphoria, headaches, epistaxis, high blood pressure, low blood pressure, mastalgia, and vaginal bleeding.

 Overdose:

 The common adaptogen ginsengs (Panax ginseng and Panax quinquefolia) are generally considered to be relatively safe even in large amounts.

 Panax ginseng is not recommended within Chinese Medicine to be administered along with anti-infective herbs unless a person is quite debilitated, because of the fear that the pathogen will be tonified. Herbalists in China believed this and according to Xu Dachun in his brief essay on ginseng (1757 A.D., during the Manchu Colonization Period): "if one administers Ginseng of a purely supplementing nature, then one will merely supplement the evil influences and help them settle down. In minor cases, the evil influences will, as a result of such mistaken therapy, never leave the body again. In serious cases, death is inevitable."

 Precautions:

 1. Reported adverse effects include erythema, fatal poisoning, persistent hiccups, severe edema, hypokalemia, diabetic relapse, diseases of the five sense organs, melanosis, hypertension, allergic reactions, high fever, etc.

 2. An analysis of the reported cases involving adverse effects found: 1) 52.9% of the cases involved the nervous system, 11.8% the circulatory system, 8.8% the digestive system, 8.8% shock and death, 17.7% others; 2) the age of the patients involved ranged from 1 month to 74 years old; 3) the number of cases involving men was 1.7 times greater than that involving women; 4) all cases involved oral administration with one exception, wherein intramuscular injection was the mode of administration; 5) dosage ranged from 3 to 40 grams; and 6) the adverse effects occurred from several minutes to 30 days after treatment.
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 Caution:

 Antagonizing veratrum root, restraining trogopterus dung and inhibiting honey locust. Large doses are said to raise blood pressure.

 No significant toxicity or drug interactions are known but excessive use can lead to sleeplessness, hypertension, headaches, oestrogenic effects, irritability or other side effects. It should not be used in pregnancy, menstrual irregularities, acute illness, hypertension, or in conjunction with other stimulants (including caffeine-containing drinks). It should not be taken continuously - occasional use or courses of 1 month followed by a 2 month interval are recommended.

 Consuming large amounts of caffeine or other stimulants while taking ginseng can result in nervousness, sleeplessness, elevated blood pressure, and other complications. Avoid ginseng if you have an acute illness, uncontrolled high blood pressure, an irregular heart rhythm, or if you are pregnant.

 Higher than commonly recommended doses may cause nervousness, insomnia, headache, skin eruptions, stomach upset, and increased menstrual bleeding and breast tenderness. If you experience any of these reactions, reduce your dose or stop taking the herb.

 Panax ginseng is different from American ginseng and Eleuthero (formerly Siberian ginseng). They are not interchangeable.
 Panax Ginseng Extract INCI Name Panax Ginseng Extract CAS 84650-12-4 EINECS ELINCS No 283-493-7 Radix Ginseng Extract Asian Ginseng Extract Ginsenosides Fructus Panax Ginseng Folium Panax Ginseng Radix Panax Ginseng photo picture image

 Toxicity and Safety Data of Ginseng and Ginsenosides:

 Acute Toxicity:Ginseng Extract.

 LD50: 16.5mg/kg (mice/Ginseng extract/hypodermic injection).

 Acute Toxicity:Sinsenoside Rb1

 LD50,Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.1110 mg/kg.Details of toxic effects not reported other lethal dose value.Reference:Chinese Herb.Shanghai Science and Technology Publishing.page/year:1280/1998

 LD50,Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.1110 mg/kg.Details of toxic effects not reported other lethal dose value.Reference:ARZNAD Arzneimittel-Forschung.Drug Research.(Editio Cantor Verlag,Postfach 1255,W-7960 Aulendorf,Fed.Rep.Ger.)V.1-1951-Volume(issue)/page/year:25,343,1975.

 LD50,lethal dose,50 percent kill.Intravenous,Rodent-mouse.243 mg/kg.Details of toxic effects not reported other than lethal dose value.Reference:SYHJAM Saengyak Hakhoechi.Journal of Society of Pharmacognosy.(HangukSaengyak Hakhoe,c/o Natural Products Institute,Seoul National Univ.,28 Yunkeon-Dong,Chong-ro-ku,Seoul 110,Korea)1970-Volume(issue)/page/year:10,61,1979.
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 Mutagenic Data:Sinsenoside Rb1. Mutation test systems-not otherwise specified.Intraperitoneal.Rodent-rat.50 mg/kg.Reference:CPBTAL Chemical and Pharmaceutical Bulletin.V.6-1958-Volume(issue)/page/year:24,2400,1976.

 Acute Toxicity:Sinsenoside Re.

 LD50,Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.465 mg/kg.Details of toxic effects not reported other lethal dose value.Reference:Chinese Herb.Shanghai Science and Technology Publishing.page/year:1280/1998

 LD50,lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.405 mg/kg.Details of toxic effects not reported other than dose value.Reference:ARZNAD Arzneimittel-Forschung.Drug Research.(Editio Cantor Verlag,Postfach 1255,W-7960 Aulendorf,Fed.Rep.Ger.)V.1-1951-Volume(issue)/page/year:25,539,1975.

 LD50,lethal dose,50 percent kill.Subcutaneous.Rodent-mouse.>1500 mg/kg.Details of toxic effects not reported other than dose value.Reference:SYHJAM Saengyak Hakhoechi.Journal of Society of Pharmacognosy.(HangukSaengyak Hakhoe,c/o Natural Products Institute,Seoul National Univ.,28 Yunkeon-Dong,Chong-ro-ku,Seoul 110,Korea)1970-Volume(issue)/page/year:10,61,1979.

 LD50,lethal dose,50 percent kill.Intravenous.Rodent-mouse.130 mg/kg.Details of toxic effects not reported other than dose value.Reference:same as above

 Acute Toxicity:Sinsenoside Rg1.

 LD50,Lethal dose,50 percent kill.Oral.Rodent-mouse.5000 mg/kg.Details of toxic effects including reduce of activity,lower of body temperature and other inhibitive actions till death.Reference:Zhong Yao You Xiao Cheng Fen Yao Li Yu Ying Yong(Effective Constituents and Application of TCM).Ji Bin Yu.Hei Long Jiang Science and Technology Publishing.page/year:223/1995

 LD50,Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.1600 mg/kg.Details of toxic effects including reduce of activity,lower of body temperature and other inhibitive actions till death.Reference:Same as above.

 LD50,Lethal dose,50 percent kill.intravenous.Rodent-mouse.396 mg/kg.Details of toxic effects including reduce of activity,lower of body temperature and other inhibitive actions till death.Reference:Same as above.

 LD50,lethal dose,50 percent kill.Intraperitoneal.rodent-mouse.405 mg/kg.Details of toxic effects not reported other than lethal dose value.Reference:ARZNAD Arzneimittel-Forschung.Drug Research.(Editio Cantor Verlag,Postfach 1255,W-7960 Aulendorf,Fed.Rep.Ger.)V.1-1951-Volume(issue)/page/year:25,343,1975.

 Acute Toxicity:Sinsenoside Rg3. LD50,lethal dose,50 percent kill.Intraperitoneal.rodent-mouse.1250 mg/kg.Details of toxic effects not reported other than lethal dose value.Reference:ARZNAD Arzneimittel-Forschung.Drug Research.(Editio Cantor Verlag,Postfach 1255,W-7960 Aulendorf,Fed.Rep.Ger.)V.1-1951-Volume(issue)/page/year:25,343,1975.
 Panax Ginseng Extract INCI Name Panax Ginseng Extract CAS 84650-12-4 EINECS ELINCS No 283-493-7 Radix Ginseng Extract Asian Ginseng Extract Ginsenosides Fructus Panax Ginseng Folium Panax Ginseng Radix Panax Ginseng photo picture image
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 Preparation and Dosage:

 Pediatric:This herb is not recommended for use in children because of its stimulant properties.
 Regulatory Status: GSL Schedule 2
 Single dose in morning:
 Dried root: 0.6-2g or by decoction
 Unless otherwise prescribed: 1 g of root per day for up to three months; a repeated course is feasible.
 Decoction: 1 g in 150 ml of water.
 Fluidextract 1:1 (g/ml): 1 ml.
 Tincture 1:5 (g/ml): 5~10 ml.
 Standardized extract (4% total ginsenosides): 100 mg twice daily.
 5-10 g for being decocted alone and mixed with other herbal tea for oral medication. 2-3 times a day;
 1-2 g each time for ginseng powder in form of infusion with hot boiled water.
 15-30 g in concentrated decoction for emergency treatment of prostration syndrome.

 In healthy individuals who wish to increase physical or mental performance, to prevent illness, or to improve resistance to stress, ginseng should be taken in one of the above dosages in cycles. For example, take every day for 2 to 3 weeks, then stop for 2 weeks.

 For help recovering from an illness, the elderly should take 500 mg twice daily for three months. Alternatively, they may take the same dosage (500 mg twice daily) for a month, followed by a two-month break. This can then be repeated if needed.
 Panax Ginseng Extract INCI Name Panax Ginseng Extract CAS 84650-12-4 EINECS ELINCS No 283-493-7 Radix Ginseng Extract Asian Ginseng Extract Ginsenosides Fructus Panax Ginseng Folium Panax Ginseng Radix Panax Ginseng photo picture image

 Use During Pregnancy and Lactation :

 The Commission E reports no known restrictions on the use of ginseng during pregnancy and lactation. Although the British Herbal Compendium contraindicates ginseng during pregnancy, this is not substantiated by use in Asia or by the Commission E (McGuffin et al., 1997). However, controlled, long-term safety studies have not been conducted. WHO has also reiterated that the safety of ginseng use during pregnancy has not been established, although it noted that ginseng is not teratogenic (WHO, 1999).
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 Interactions:

 Interactions with Other Drugs:

 The British Herbal Compendium contraindicates the use of ginseng with stimulants, including excessive use of caffeine (Bradley, 1992). The WHO monograph cites two cases of ginseng interaction with phenelzine, a monoamine oxidase inhibitor, although the clinical significance of this interaction was yet to be determined (WHO, 1999).

 If you are currently being treated with any of the following medications, you should not use ginseng without first talking to your healthcare provider:

 Blood Thinning Medications:

 There have been reports that Asian ginseng may possibly decrease the effectiveness of the blood-thinning medication, warfarin. In addition, ginseng may inhibit platelet activity and, therefore, should probably not be used with aspirin either.

 Caffeine:

 While taking ginseng, it is wise to avoid caffeine or other substances that stimulate the central nervous system because the ginseng may increase their effects, possibly causing nervousness, sweating, insomnia, or irregular heartbeat.
 Panax Ginseng Extract INCI Name Panax Ginseng Extract CAS 84650-12-4 EINECS ELINCS No 283-493-7 Radix Ginseng Extract Asian Ginseng Extract Ginsenosides Fructus Panax Ginseng Folium Panax Ginseng Radix Panax Ginseng photo picture image

 Haloperidol:

 Ginseng may exaggerate the effects of this anti-psychotic medication, so these should not be taken together.

 Morphine:

 Ginseng may block the pain killing effects of morphine.

 Phenelzine and other MAO inhibitors for Depression:

 There have been reports of a possible interaction between ginseng and the antidepressant medication, phenelzine (which belongs to a class known as monoamine oxidase inhibitors [MAOIs]), resulting in symptoms ranging from manic-like episodes to headache and tremulousness.
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Reference:
  • 1.What is the differenciation between Panax ginseng and Ginsengs,How to use Panax Ginseng,Chemistry and Pharmacology,Substitutes?

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Available Product
  • Name:Panax Ginseng Extract
  • Serie No:R079.
  • Specifications:Ginsenosides 20%50%HPLC.10:1TLC
  • INCI Name:PANAX GINSENG EXTRACT
  • EINECS/ELINCS No.:283-493-7
  • CAS:84650-12-4
  • Chem/IUPAC Name:Panax Ginseng Extract is an extract of the roots of the ginseng,Panax ginseng,Araliaceae
  • Other Names:Ginseng Stem Leaf Extract.Panax ginseng C.A.Mey. Extract.Chinese Ginseng Extract.Panax ginseng Meyer Extract.Ren Cen.

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