Description and remedy use of Tall Gastrodia Tuber,Rhizoma Gastrodiae and its Determination Method...
- Basic Botanical Data of Tall Gastrodia Tuber.
- Botanical Desription:Tall Gastrodia Tuber.
- Phytochemicals and constituents of Tall Gastrodia Tuber:Rhizoma Gastrodiae.
- Gastrodia Tuber Remedy for Migraines.
- Functions and indications of Tall Gastrodia Tuber:Rhizoma Gastrodiae.
- Gastrodia Formula and Gastrodia Elixir.
- Treatment of Vascular Dementia of Tall Gastrodia Tuber:Rhizoma Gastrodiae.
- Actions and Pharmacology of Tall Gastrodia Tuber:Rhizoma Gastrodiae.
- How to Use Tall Gastrodia Tuber:Rhizoma Gastrodiae.
- Determination Method of Gastrodine in Product of Rhizoma Gastrodiae.
- Research Update:Gastrodia Tuber,Rhizoma Gastrodiae.
Treatment of Vascular Dementia of Tall Gastrodia Tuber:Rhizoma Gastrodiae.:
The Chinese herb gastrodine may be just as effective as conventional drugs for the treatment of vascular dementia, which occurs in some patients after a stroke. Vascular dementia is the second most common cognitive disorder, after Alzheimer's.
Researchers of china studied 120 stroke patients with vascular dementia. The patients were divided into two groups. The first group was given the gastrodine herbal compound granule three times a day for 12 weeks. The second group was given Duxil -- a conventional drug used to treat stroke-related dementia. Both treatments were dissolved in hot water, so the patients could take them orally.
Results of the study show both the gastrodine compound and Duxil were effective in improving dementia-related problems in patients who suffered a stroke. The gastrodine group improved by about 51 percent and the Duxil group improved by about 52 percent. However, the gastrodine group suffered fewer side effects and had higher scores for improved behavior and personality.
Researchers say gastrodine treatment might be a better alternative for some patients. Chemical drugs are effective in the treatment of cognitive memory function in dementia, but these drugs are expensive and have side effects. This study might result in doctors considering the use of herbal medications, such as gastrodine compound granules.
The gastrodine compound used in the study was extracted from tall gastrodia tuber plants and six other herbs. It is the first of new herbal drugs tested in clinical trials for dementia.
Gastrodia Tuber Extract Improves Mental Function in Stroke Patients:
Between 1 percent and 3 percent of the world's adult population suffers from vascular dementia, making it the second most common form of dementia behind Alzheimer's disease. It occurs when small blood vessels in the brain become diseased or cease function, and can be caused by a large stroke or a series of smaller strokes. Depending on the severity of the condition, vascular dementia can cause problems with one's memory, behavior and cognitive abilities. Advanced cases can leave a person unable to work, or to carry out everyday tasks such as bathing, cooking or dressing.
In China, one of the herbs being studied for the treatment of vascular dementia is gastrodia (gastrodia elata blume), a type of orchid native to east Asia. Gastrodia has been a part of traditional Chinese medicine for centuries. It was first mentioned in the Shennong Bencao Jing more than 1,900 years ago, and has traditionally been used to treat headaches, dizziness, vertigo, and related conditions, and to improve circulation.
In research presented at the American Heart Association's Second Asia Pacific Scientific Forum in Honolulu, Hawaii this summer, Dr. Jinzhou Tian, director of the Beijing University of Chinese Medicine Institute of Geriatrics, delivered the results of a trial showing that an extract derived from gastrodia tuber (gastrodine) was effective in improving memory, language, and other cognitive functions in certain types of vascular dementia patients. Patients taking the extract also experienced significant improvements in behavior and personality scores, without the side-effects associated with most pharmaceuticals.
In the study, conducted at the Beijing Bongzhimen Hospital, Dr. Tian's team identified 120 stroke patients diagnosed with mild-to-moderate vascular dementia of at least three months duration. All of the patients were assessed for vascular dementia at the beginning of the trial, and divided into two groups. One group (70 patients) received a gastrodine compound granule containing 2.6 milligrams of gastrodine, dissolved in hot water and taken orally. The second group (50 patients) received a drug combination used to treat stroke patients in China called Duxila, also dissolved in hot water and administered orally. The extracts were taken three times a day for 12 weeks.
The researchers utilized two tests were used to evaluate the patients' progress: the Mini-Mental State Exam (MMSE), which measures memory, orientation, calculation and language skills, and the Blessed Behavioral Scale (BBS), which measures behavioral characteristics, including personality, activities of daily living and overall behavior. Test scores were taken at baseline and endpoint for comparison.
Overall improvement rates were nearly identical for both groups. Thirty-six gastrodine patients (51.4 percent) showed "much improvement" or "some improvement" in their dementia symptoms as determined by the researchers; the improvement rate was slightly higher in Duxila patients (52 percent).
In the gastrodine group, there were significant increases in the average MMSE score at the end of the study compared to baseline. In the areas of memory, orientation, calculation, and language, the MMSE showed similar improvement in both groups.
When analyzing the BBS scores, however, the scientists discovered significant differences in patients taking gastrodine versus those in the Duxila group. Behavioral scores dropped an average of more than three points per patient in the gastrodine group, from 18.76 at baseline to 15.72 at the study's conclusion. According to the researchers, a BBS score equal to or greater than 16 is considered abnormal; scores below 16 are normal. In comparison, the average BBS score in Duxila patients remained above normal at endpoint (17.08) The gastrodine patients also suffered fewer side-effects.
In a press release given during the meeting, Dr. Tian theorized that gastrodine may have increased cerebral blood flow in the dementia patients, resulting in the improved cognitive and behavioral scores. They also admitted that a longer study - one lasting a minimum of six months - should be conducted to determine the clinical effectiveness of the gastrodine extract and its role in the treatment of vascular dementia.
Given the positive results shown in their initial trial, however, the researchers added that further research into herbal therapies for vascular dementia is clearly warranted.
"Chemical drugs, such as cholinesterase inhibitors, are effective in the treatment of cognitive and memory function in dementia, but these drugs are expensive and have side-effects," Dr. Tian said. "This study might result in doctors considering the use of herbal medications, such as gastrodine compound granules, to supplement the treatment of mild and moderate cognitive impairment in primary care for the elderly with cerebral ischemic damage."
- 1.Description and remedy use of Tall Gastrodia Tuber,Rhizoma Gastrodiae and its Determination Method...
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