Turmeric Root or Curcuma Root,Phytochemicals and Applications.
- Basic Botanical Data and Identification of Turmeric Root.Curcuma Root.
- Description of Turmeric Root.Curcuma Root.
- Origin of Curcuma root.
- Curcuma Root Appearance and characters.
- Powdered plant material of Curcuma Root.
- Chemical assays and Phytochemicals of Turmeric Root.Curcuma Root.
- Medicinal uses of Turmeric Root.Curcuma Root.
- Experimental pharmacology of Turmeric Root.Curcuma Root.
- Functions of Turmeric Root.Curcuma Root.
- Curcuma Root Suggestions and Administrations.
- Literature from Chinese historical sources:Curcuma Root.
- Modern Researches of Turmeric Root.Curcuma Root.
- Curcuma longa Common Application.
- Dose escalation of a curcuminoid formulation.
- Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury.
- Quality control including chromatographic fingerprint profiling.
- Research Update:Curcumae Longae.Curcuma longa.
Medicinal uses of Turmeric Root.Curcuma Root.:
Uses supported by clinical data:
The principal use of Rhizoma Curcumae Longae is for the treatment of acid, flatulent, or atonic dyspepsia.
Uses described in pharmacopoeias and in traditional systems of medicine:
Treatment of peptic ulcers, and pain and inflammation due to rheumatoid arthritis and of amenorrhoea, dysmenorrhoea, diarrhqea, epilepsy, pain, and skin diseases.
Uses described in folk medicine, not supported by experimental or clinical data:
The treatment of asthma, boils, bruises, coughs, dizziness, epilepsy, haemorrhages, insect bites, jaundice, ringworm, urinary calculi, and slow lactation.
Tumeric is a mild aromatic stimulant seldom used in medicine except as a colouring. It was once a cure for jaundice. Its chief use is in the manufacture of curry powders. It is also used as an adulterant of mustard and a substitute for it and forms one of the ingredients of many cattle condiments. Tincture of Turmeric is used as a colouring agent, but the odour is fugitive. It dyes a rich yellow. Turmeric paper is prepared by soaking unglazed white paper in the tincture and then drying. Used as a test for alkaloids and boric acid.
Many Other Uses:
Turmeric (Curcuma longa) Turmeric contains an incredible essential oil and its main constituent, curcumin. It is anti-inflammatory and an antioxidant. It is excellent for cystic fibrosis, even turning off the Cystic Fibrosis gene and aids asthma by opening the chloride channels in the cell membrane which enhances breathing at a cellular level. It is a dual inhibitor of arachidonic acid metabolism and helps with both cholesterol issues and weak detoxification capacity of the liver. It is a standard in our treatment of Alzheimer's Disease.
Documented Properties and Actions:
Anti-inflammatory, Antioxidant, Anti-mutagenic, Anti-cancerous, Cholagogueue, Depurative, Diuretic, Fumitory, Hemostatic, Hepatoprotective, Lactagogue, Stomachic, Tonic, Vulnerary
Anti-inflammatory (Chuthaputti and Permpipat 1994)
Antifungal activity (Wuthi-udomlert et al., 2000, Apisariyakul et al., 1995 )
Anti-carcinogenesis (Limtrakul et al., 1997, Limtrakul et al 2001)
Antiflatulance: The active principle are essential oils.
Antispasmodic activity: Crude extract of the tuber decreased the constriction of smooth muscle such as uterus stimulated with acetylcholine, barium chloride andserotonin.
Antimicrobial activity: Crude extract and essential oil inhibited both bacteria and fungi.
Anti-inflammatory activity: Crude, crude extract and isolated curcumenoids exhibited the anti-inflammatory activity in animal models.
Hepatoprotective effect: Curcumin has antihepatotoxic activity in vitro and in vivo in animalexperiments.
Antioxidant activity: An extract of tuber and curcumenoids exhibited strong antioxidant activity.
Antimutagenic activity: Curcumenoids exhibited apoptosis of cancer cells.
Mosquito repellant: Essential oil was used for mosquitos repellant.
Application of Curcumin:
Curcumin is known for its antitumor, antioxidant, antiarthritic, anti-amyloid and anti-inflammatory properties. Anti-inflammatory properties may be due to inhibition of eicosanoid biosynthesis.
A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
Curcumin is the principal curcuminoid of the Indian curry spice turmeric, the other two curcuminoids being demethoxycurcumin and Bis-demethoxycurcumin.The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two tautomeric forms, keto and enol. The enol form is more energetically stable in the solid phase and in solution,It is also hepatoprotective.
Curcumin can be used for boron quantification in the so-called curcumin method. It reacts with boric acid forming a red colored compound, known as rosocyanine.Since curcumin is brightly colored, it may be used as a food coloring. As a food additive, its E number is E100.
Antioxidant Property: Curcumin acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage. Curcuminoids induce glutathione S-transferase and are potent inhibitors of cytochrome P450.
For the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of curcumin. Its anticancer effects stem from its ability to induce apoptosis in cancer cells without cytotoxic effects on healthy cells. Curcumin can interfere with the activity of the transcription factor NF-gammaB, which has been linked to a number of inflammatory diseases such as cancer.Indeed, when 0.2% curcumin is added to diet given to rats or mice previously given a carcinogen, it significantly reduces colon carcinogenesis (Data from sixteen scientific articles reported in the Chemoprevention Database). A 2007 report indicates that curcumin may suppress MDM2, an oncogene involved in mechanisms of malignant tumor formation.
Inhibition of beta-amyloid and Anti-aging: Alzheimer's disease prevent:
A 2004 UCLA-Veterans Affairs study involving genetically altered mice suggests that curcumin might inhibit the accumulation of destructive beta-amyloid in the brains of Alzheimer's disease patients and also break up existing plaques associated with the disease.
Mental alert and improves mental functions:
There is also circumstantial evidence that curcumin improves mental functions; a survey of 1010 Asian people who ate yellow curry and were between the ages of 60 and 93 showed that those who ate the sauce "once every six months" or more had higher MMSE results than those who did not.From a scientific standpoint, though, this does not show whether the curry caused it, or people who had healthy habits also tended to eat the curry, or some completely different relationship.
Little curcumin, when eaten, is absorbed-- 2 grams of curcumin alone resulted in undetectable to very low serum levels.Co-supplementation with 20 mg of piperine (extracted from black pepper) significantly increased the absorption of curcumin by 2000%. However, due to its effects on drug metabolism, piperine should be taken cautiously (if at all) by individuals taking other medications. Some benefits of curcumin, such as the potential protection from colon cancer, may not require systemic absorption. Recently, a polymeric nanoparticle encapsulated formulation of curcumin ("nanocurcumin") has been synthesized which has the potential to bypass many of the shortcomings associated with free curcumin, such as poor solubility and poor systemic bioavailability. Nanocurcumin particles have a size of less than 100 nanometers on average, and demonstrate comparable to superior efficacy compared to free curcumin in human cancer cell line models.
- 1.Turmeric Root or Curcuma Root,Phytochemicals and Applications.
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