Botanical info and medicinal uses of Ecliptae Herba.
Contents
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- Basic Botanical info and Identification of Ecliptae Herba.
- Eclipta prostrata Physical Characteristics.
- Cultivation details of Eclipta prostrata.
- Eclipta prostrata Phytochemicals and Constituents.
- Medicinal Uses of Ecliptae Herba.
- Traditional Functions and Notes of Ecliptae Herba.
- Pharmacological studies:Ecliptae Herba.
- Eclipta prostrata Quality control including chromatographic fingerprint profiling.
- Suggestions and Administrations of Eclipta prostrata.
- Research Update:Eclipta prostrata.
Pharmacological studies:Ecliptae Herba.:
AntivenOn effect:
The ether extract of the dried aerial parts showed antivenOn effect, when administered 0.5 mg I.P. in mouse. The methanol extract (80%) of the dried aerial parts shows antihepatotoxic activity, administered in rat (1 mg/ml) (Kim and Park, 1994). The hydroalcoholic extract of the dried leaf reported analgesic activity, when administered intragastrically in mouse (100.0 mg/kg). The chloroform and methanol extract of the dried leaf (1.0 gm/ml) showed antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus (Naovi et al., 1991; Phadke and Kulkarni, 1989; Farouk et al.,1983)
Various biological activities have been reported in the literature for extracts of E. prostrata: SNC (Debelmas et al., 1976); hepatoprotective (Chandra et al., 1987; Singh et al., 1993; Sharma et al., 1991; Saxena et al., 1993); antiviral (Kusumoto et al., 1995; Jayaram et al., 1997; Zheng et al., 1988); antirheumatic (Dabral and Sharma, 1983); molluscicidal (Mendes et al., 1984); antimalarial (Misra et al.,1991) and antifertility (Misra et al.,1979).
Effect on Proteolytic and Hemorrhagic activities:
The partially purified ethyl acetate extract (PEE) of Eclipta prostrata L. was found to c
ontain 47% of wedelolactone as its major constituent. PEE and wedelolactone demonstrated strong antiproteolytic and antihemorrhagic activity agianst Malayan Pit Viper venom (MPV) in a dose d ependent manner. The extract, at 5 mg/mL, could inhibit proteolytic activity of 100 ug of the venom and hemorrhagic activity of 3 minimum hemorrhagic doses (MHD) to 95% and 65% respectively. At the same concentration, wedelolactone could neutralize the proteolytic activity at around 76% and, at doses of 0.25-1.0mg/mL, offered protection against hemorrhagic activity of the venom in the range 3-3.5%. Both PEE and wedelolactone displayed partial antiphospholipase A2 activity (21% for PEE and 7% for wedelolactone ) and could not neutralize the lethal effect of either 2LD50 0r 4 LD 50 of MPV venom (Pithayanukul, et al 2007).
Clinical trials:
A clinical trial was conducted on 50 children suffering from hepatitis. All patients were administered Eclipta alba powder with honey in doses of 50 mg/kg body wt. in three divided doses for a period of 1-5 weeks. The results revealed that 80 % of patients recovered fully. In another clinical trial 100 % cure in patients of infective hepatitis was observed with Eclipta alba powder (Ministry of Health and Family Welfare Government of India, 2001).
A clinical trial was conduced on 30 patients of viral hepatitis with a compound herbal preparation containing Eclipta alba as one of the ingredients. The response was excellent in terms of clinical as well as biochemical parameters as compared to the placebo group (Ministry of Health and Family Welfare Government of India, 2001).
Reference:
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- 1.Botanical info and medicinal uses of Ecliptae Herba.
Article Information:
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