Scientific Study: Vitex agnus castus Phyto formulation Treatment of Premenstrual Syndrome.


Scientific Study: Vitex agnus castus Phyto formulation Treatment of Premenstrual Syndrome.

Vitex Chaste Berry Vitexin  Premenstrual syndrome Definition:Premenstrual syndrome refers to symptoms that occur between ovulation and the onset of menstruation. The symptoms include both physical symptoms, such as breast tenderness, back pain, abdominal cramps, headache, and changes in appetite, as well as psychological symptoms of anxiety, depression, and unrest. Severe forms of this syndrome are referred to as premenstrual dysphoric disorder (PMDD). These symptoms may be related to hormones and emotional disorders.

PMS Description:

 Approximately 75% of all menstruating women experience some symptoms that occur before or during menstruation. PMS encompasses symptoms severe enough to interfere with daily life. About 3-7% of women experience the more severe premenstrual dysphoric disorder (PMDD). These symptoms can last 4-10 days and can have a substantial impact on a woman's life.

 The reason some women get severe PMS while others have none is not understood. PMS symptoms usually begin at about age 20-30 years. The disease may run in families and is also more prone to occur in women with a history of psychological problems. Overall however, it is difficult to predict who is most at risk for PMS.

Causes and symptoms:

 Vitex Chaste Berry Vitex Agnus Castus Vitex BerryBecause PMS is restricted to the second half of a woman's menstrual cycle, after ovulation, it is thought that hormones play a role. During a woman's monthly menstrual cycle, which lasts from 24-35 days, hormone levels change. The hormone estrogen gradually rises during the first half of a woman's cycle, the preovulatory phase, and falls dramatically at ovulation.

 After ovulation, the postovulatory phase, progesterone levels gradually increase until menstruation occurs. Both estrogen and progesterone are secreted by the ovaries, which are responsible for producing the eggs. The main role of these hormones is to cause thickening of the lining of the uterus (endometrium).

 However, estrogen and progesterone also affect other parts of the body, including the brain. In the brain and nervous system, estrogen can affect the levels of neurotransmitters, such as serotonin. Serotonin has long been known to have an effect on emotions, as well as eating behavior. It is thought that when estrogen levels go down during the postovulatory phase of the menstrual cycle, decreases in serotonin levels follow. Whether these changes in estrogen, progesterone, and serotonin are responsible for the emotional aspects of PMS is not known with certainty. However, most researchers agree that the chemical transmission of signals in the brain and nervous system is in some way related to PMS. This is supported by the fact that the times following childbirth and menopause are also associated with both depression and low estrogen levels.

 Symptoms for PMS are varied and many, including both physical and emotional aspects that range from mild to severe. The physical symptoms include: bloating, headaches, food cravings, abdominal cramps, headaches, tension, and breast tenderness. Emotional aspects include mood swings, irritability, and depression.

Vitex agnus castus Phyto formulation Treatment of premenstrual syndrome

 Vitex Chaste Berry Vitex Agnus Castus Vitex BerryA multicentric noninterventional trial (open study without control) to investigate the efficacy and tolerance of a drug in a large number of patients under routine medical conditions was performed for a new solid preparation from an extract of the fruit of Vitex agnus castus (VAC, Vitex, chaste tree, Chasteberry) in 1634 patients suffering from premenstrual syndrome (PMS).

 A specific questionnaire was developed for determining the effect of Vitex on psychic and somatic complaints, on the four characteristic PMS symptom complexes depression, anxiety, craving, and hyperhydration (DACH), and on single groups of symptoms.

 After a treatment period of three menstrual cycles 93% of patients reported a decrease in the number of symptoms or even cessation of PMS complaints. To a certain extent, this effect was observed within all symptom complexes and correlated with the global assessment of therapeutic efficacy.

 Whereas 85% of physicians rated it as good or very good, 81% of patients assessed their status after treatment as very much or much better. Analysis of frequency and severity of mastodynia as the predominant symptom revealed that complaints still present after 3 months of therapy were mostly less severe.

 Ninety-four percent of patients(94%) assessed the tolerance of Vitex treatment as good or very good. Adverse drug reactions were suspected by physicians in 1.2% of patients, but there were no serious adverse drug reactions.

 Hence, the risk/benefit ratio of the new Vitex preparation can be rated as very good, with significant efficacy for all aspects of the multifaceted and inhomogeneous clinical picture of PMS, with a safety profile comparable to other Vitex preparations.


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Available Product
  • Name:Vitex.Chaste Berry Extract
  • Serie No:R097.
  • Specifications:10:1TLC.
  • INCI Name:Vitex Agnus Castus Extract
  • Other Names:Vitex Trifolia Extract,Cloister Pepper Extract,Fructus Viticis Extract.
  • CAS:Vitexin,525-82-6
  • Chem/IUPAC Name:N/A
  • Other Names:Chaste Berry,Vitex trifolia L.var.simplicifolia Cham,Vitex trifolia L.,Vitex agnus-castus,Vitex rotundifolia,Vitex trifolia,Fructus viticis Verbenaceae,Chasteberry,Monk's pepper,Cloister pepper,Agnus Castus,Man jing zi,Agnus Castus,Cloister Pepper,Monk's Berry,Monk's Pepper,Vitex.

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Vitex.Chaste Berry Extract INCI Name Vitex Agnus Castus Extract Vitex Berry Extract Chaste Tree Berry Extract VITEX-CHASTE BERRY

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