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This Babchi seeds or that Psoralea corylifolia,very useful phytochemicals in the future...
Basic Botanical and Description of Babchi seeds,Psoralea corylifolia:
Botanical Source: Psoralea pinnata. L. or Psoralea corylifolia L.(Psoralea corylifolia Linn.)
Plant Part: Dry fruit seed.(other part used:Roots, leaves.)
Family genus:Fabaceae.(Papillionaceae)
English Name:Babchi seeds,Malaytea Scurfpea Fruit
Latin name: Psoralea corylifolia;Fructus Psoraleae
Common Chinese name:BU GU ZHI;Babchi Seeds,Bu Gu Zhi,
Common other names:Bakuchi;Psoralea Seed;Osiralean seeds,Bemchi ;Bawchi;Fountain bush, fonteinbos (Afr.), bloukeur (Afr.), penwortel (Afr.), umHlonishwa (Zulu);Psoralea Fruit, Scurfy Pea;Babchi Seeds, Bavachi, Bavanchalu, Bavanchi Bavchi, Bhavanchi-vittulu, Bawachi, Bhavaj, Bobawachi, Bogi-vittulu, Hakuchi, Kantaka, Karpokarishi, Karu-bogi, Krishnaphala, Latakasturi, Somaraji, Sugandha kantak, Vabkuchi, Vakuchi
Habitat: Common all over China and India in dry and sandy places.
Common and popular names of Bemchi (Psoralea corylifolia) around the world
1. Arabic:Loelab el abid, Mahalep
2. Bengal:Barachi, Bavachi, Hakuch, Latakasturi
3. Kanarese:Bavanchi
4. Srilanka:Ravoli
5. Chineses:Ku Tzu, Pu Ku Chih
6. Gujarati:Babchi, Bavacha, Bawachi
7. Hindi:Babachi, Babchi, Bavanchi, Bukchi
8. Marathi:Bavachya, Babchi, Bavachi
9. Persian:Waghchi
10. Sanskrit:Aindavi, Asitatvacha, Avalguja, Bakuchi, Chandralekha, Chandra prabha, Chandraraji, Kalameshi, Kambojii, Kantaka, Krishna, Krishnaphala, sita, Sitavari, Soma, Somaraji, Suprabha,
11. Sinhalese:Bodi
12. Tamil:Karpokarishi, Karpurvarishi
13 Telugu:Bhavanji, Kalanginja, Karubogi, Korjastham
14 Urldu:Babechi
15 Uriya:Bakuchi
Title Botanical Narrative of Psoralea corylifolia:
A herbaceous annual, is about 1 m in height. The leaves are arranged in racemes.The purple seed pods contain dark elongated seeds.
Psoralea is a climbing bean found throughout China. Psoralea seeds, which are harvested in the fall when they have ripened, should be large, solid, and black. Unlike garden beans, psoralea seeds are pungent and bitter.
Psoralea seeds are pungent and bitter. This plant is one of the main herbs in traditional Chinese herbal medicine for the treatment of skin conditions. Bu Gu Zhi, the Chinese name of this herb means ttonify bone resin because it helps promote bone calcification. Psoralens, a component of Psoralea, induces pigmentation of the skin.
Remedies For :Aromatic, Antihelmintic, Antibacterial, Antifungal, Diuretic, Diaphoretic, Laxative, Stimulant, Aphrodisiac.
Bu Gu Zhi (Psoralea corylifolia):Libido Stimulator
Libido Stimulator:Treat impotence and premature ejaculation and to improve vitality
Valued as a yang tonic, bu gu zhi is taken in China to treat impotence and premature ejaculation and to improve vitality. The one-seeded fruits (or the seed plus the seedpod) are highly regarded as an aphrodisiac and tonic to the genital organs.
It is used in the treatment of debility and other problems reflecting ¡°kidney yang deficiency¡±, such as febrile diseases, premature ejaculation, impotence, lower back pains, frequent urination, incontinence, bed wetting etc.
Benefits of Psoralea corylifolia:
Psoralea is one of the main herbs in traditional Chinese herbal medicine for the treatment of skin conditions. It has been used in the treatment of eczema and hair loss. In addition, it acts against staph infections and helps stimulate the heart.
Psoralea is used to promote bone calcification, making it useful for treating osteoporosis and bone fractures.
Benefits of psoralea for specific health conditions include the following:
As hair tonic: In the treatment of leucoderma, leprosy, scabies, dermatatis, vitiated pitta and muco memberanous disorders.
For hair Growth: Rub this oil on the scalp for a few minutes. Continue this process for some weeks. After a few days, the colour of the scalp-skin will turn red. Stop the treatment at this stage.
Cancer: Psoralea contains bavachinin, corylfolinin, and psoralen, all of which inhibit the multiplication of osteosarcoma and lung cancer cells.
Note:Immunomodulatory and antitumour properties of Psoralea corylifolia seeds:Psoralea corylifolia seed extract has been found to stimulate the immune system in mice. Administration of the extract was found to inhibit EAC ascitic tumour growth and stimulate natural killer cell activity, antibody-dependent cellular cytotoxicity, antibody-forming cells and the antibody complement-mediated cytotoxicity during tumour development.
Psoriasis: Psoralea is a natural source of psoralens, a group of chemicals that includes the active ingredient of a conventional psoriasis medication called methoxsalen (8-MOP, Oxsoralen-Ultra). Psoralens make ultraviolet-light therapy for this disorder more effective.
Vitiligo: Psoralea helps fight vitiligo, a disorder in which patches of skin lose their pigmentation. In one study, forty-nine patients underwent six months of psoralea treatment. Of these patients, 14 percent were cured and another 19 percent regained pigmentation on at least two-thirds of the affected skin.
Other uses: Bone cancer:The Chinese name of this herb, bu gu zhi, means "tonify bone resin."
Scientific Evidence:Because Psoralea promotes bone calcification it is useful in treating osteoporosis and other bone diseases. This herb is also used to stop the spread of some forms of cancer as it inhibits the multiplication of osteosarcoma (bone cancer cells) and lung cancer cells. Psoralea is used to treat vitiligo, a disorder in which the skin looses its pigmentation. Studies of the effects of Psoralea on vitiligo have shown positive results. This herb can also be used for treating psoriasis.
Phytochemicals and Content:Psoralea corylifolia seed
Main content: psoralen,C11H6O3,(0.230%~0.980); isopsoralen,C11H6O3,(0.210%~0.975%),etc.
Chemical Name:7H-furo[3,2-g]chromen-7-one or 7H-furo[3,2-g]benzopyran-7-one.
Synonyms:7H-Furo[3,2-g]benzopyran-7-one;Furo[3,2-g] coumarin;Ficusin;Furocoumarin;Furo(2',3',7,6)courmarin;Furo(4',5',6,7)coumarin;Psoralen;Psoralene.
Molecular Formula:C11H6O3 Molecular Weight: 186.17 Melting Point:158~161 Deg C CAS RN:66-97-7. EINECS:200-639-7. Beilstein Reference:0152784;5-19-04-00445; RTECS:LV0944000
Dictionary note:Psoralen (also called psoralene) is the parent compound in a family of natural products known as furocoumarins. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. Psoralen occurs naturally in the seeds of Psoralea corylifolia, as well as in the common Fig, celery, parsley and West Indian satinwood. It is widely used in PUVA (=Psoralen +UVA) treatment for psoriasis, eczema and vitiligo. Although safe to mammals, it should be used with care since many furocoumarins are extremely toxic to fish, and some are indeed used in streams in Indonesia to catch fish.
Pharmacology Study of Psoralea corylifolia seed
Pharmacology of Psoralen(C11H6O3):
Pigmented deposit: Oral taken by rabbit at dose 4 mg/g,exposed in sun of rabbit back skin,pigment deposit occurs.Reference:Modern Study of TCM and Clinical Applications,by Yin Jian,etc.Xue Yuan Publishing,Beijing,1993,382.
Anti-Cancer and Boost Immune System: Black light 250 ug/ml,shows strong killing effects on mice osteosarcoma cell S180,MTT method shows:relative anti-tumor activity index of proralen for mucoepidermoid carcinoma cells(IC50: 8.6ug/ml): 15;MTT method shows psoralen release stronger kill effects on leukaemia,when dosage lower than 8 ug/ml,the kill capacity decreased;Intraperitoneal injection 1 time daily 0.2 ml dose to mice,10 days period,inhibition ratio of transplanted tumor as :S180:40.2%;EAC:68.0%;H22:20.5%;apply Ethyl Carbamate to induce lung tumor of mice,dose 1 mg/ml(contains psoralen and isopsoralen),strong immune boost effects got.Reference:Shaan Xi Zhong Yi,1990,11(9):427,by Zhao Jianbing,etc.Shi Yong Kou Qiang Yi Xue Za Zhi,1990,6(4):320;by Wu Junzheng,etc.Zhong Xi Yi Jie He Za Zhi,1990,10(6):370;by Lu Zehua,etc.Shaan Xi Xin Yi Yao,1983,(10):49,by Yang Yi Can,etc.Zhong Xi Yi Jie He Za Zhi,1989,(1)2:736,by Yang Yican,etc.
Anti-Bacteria: Black light 0.5 ug,shows strong inhibition on bacteria such as:Microsporum Canis,Microsporum gypseum,microsporum ferrugineum,Trichophyton rubrum,Trichophyton mentagrophytes,Staphylococcus aureus,Candida albicans,Group B Streptococcus,E.coli,Pseudomonas aeruginosa,etc.
Effects on Blood System: Stanch effects on uterus,bleeding of uterus,nose and gum,diastolic function of Bronchial Smooth Muscle proved.
Heart Effect: Expand coronary vessels of isolated rabbit heart,Posterior Pituitrin induced coronary artery shrink,boost and strong the heart shrink capacity.
Sleep Effect: Extending sleeping of mice induced by Pentobarbital Sodium and Barbital sodium.
Effect on medicine metabolism: Increase liver microsome protein concentration,thus increase concentration of P-250 and NADPH-cytochrome C.
Pharmacology of Isopsoralen(C11H6O3):
Pigmented deposit: Pigmented deposit proved,but weaker than psoralen,prompt re-birth of skin pigmented mole.
Anti-Early Pregnant Effects: Anti-Early Pregnant experiment shows that 10 mg injection to mice uterus released strong anti-early pregnant effects.
Applications and Studies:Psoralea and Its Constituents
Evaluation of the antioxidant and antimicrobial properties of bakuchiol:antimicrobial agents against oral pathogens:
Phytochemical investigation of Psoralea corylifolia recently identified result and conclusions following:
Use of antioxidants from natural sources, especially plants, is becoming more popular due to the health concerns arising from the use of synthetic antioxidants in the food industry.
Psoralea corylifolia is an annual plant found in China and India and is widely used in folklore medicine for a number of ailments.
The seeds of Psoralea corylifolia were extracted with solvents of increasing polarity. The hexane extract exhibited the maximum 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and therefore was subjected to activity guided chromatographic fractionation.
This led to the isolation and characterization of Bakuchiol, a known meroterpenoid. The antioxidant properties of Bakuchiol were spectrophotometrically evaluated and compared to Vitamin E and Butyl Hydroxy Anisole (BHA) using the DPPH radical scavenging method and monitoring the peak at 517 nm.
Results of the antioxidant and antimicrobial assays of Bakuchiol would be presented:
In this study, we evaluated in vitro the antimicrobial activities of bakuchiol against some oral microorganisms and showed that bakuchiol had bactericidal effects against all bacteria tested, including S. mutans, S. sanguis, S. salivarius, S. sobrinus, E. faecalis, E. faecium, L. acidophilus, L. casei, L. plantarum, A. viscosus, and P. gingivalis, with MICs ranging from 1 to 4 ug/ml and sterilizing concentrations for 15 min ranging from 5 to 20 ¦Ìg/ml.
The antimicrobial activity of bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose. Bakuchiol was found to have cytotoxic activity against L929 cells in cell culture, and this cytotoxic activity was considered to be due to injury of the cell membrane, based on electron microscopic observation and hemolytic activity. Recently, various biological activities of bakuchiol have been reported, e.g., anti-inflammatory effects, inhibition of mitochondrial lipid peroxidation, stimulation of the immune system, inhibition of DNA polymerase, inhibition of papilloma formation, and prevention of diabetes.
Therefore, bakuchiol might be a promising lead compound for development of antimicrobial agents against oral pathogens in humans.
Antimicrobial Activities of Bakuchiol against Oral Microorganisms:
Bakuchiol was isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine
In a study recently from China, the antimicrobial activities of bakuchiol against some oral microorganisms were evaluated in vitro. The cell growth of Streptococcus mutans was inhibited in a bakuchiol concentration-dependent manner, and growth of S. mutans was completely prevented by 20 ug of bakuchiol per ml.
The bactericidal effect of bakuchiol on S. mutans was dependent on temperature and stable under the following conditions: sucrose, 0 to 10% (wt/vol); pH, 3.0 to 7.0; organic acids (3% [wt/vol] citric and malic acids).
Bakuchiol showed bactericidal effects against all bacteria tested, including S. mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus sobrinus, Enterococcus faecalis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Actinomyces viscosus, and Porphyromonas gingivalis, with MICs ranging from 1 to 4 ¦Ìg/ml and the sterilizing concentration for 15 min ranging from 5 to 20 ¦Ìg/ml.
Furthermore, bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth. Thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries.
Inhibit the aggregation of rabbit platelets:MeOH extract of the seeds of Psoralea corylifoli L.
The MeOH extract of the seeds of Psoralea corylifoli L. was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid, collagen and PAF.
Bioassay-directed fractionation led to the isolation of three flavonoids, isobavachalcone, neobavaisoflavone and bavachin. Compounds (1) and (2) inhibited platelet aggregation.
Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds:
Some scientif prove find:Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA) - induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids.
DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia seed?:
Psoralea corylifolia is an ancient medicinal plant of India and China. It is still cultivated for medicinal purposes in China today. Since P. corylifolia's folkloric uses included cancer treatment, we tested the plant extract using and intact cell assay which can detect inhibitors of specific DNA replication enzymes.
Drugs which target enzymes of DNA replication often have anticancer activity. The test indicated the presence of one or more DNA polymerase inhibitors, and the assay was then used to guide their isolation. The activity of the plant was mainly due to bakuchiol and to corylifolin (a new compound).
Several weakly active topoisomerase II and DNA polymerase inhibitors were also detected as subfractions of the plant were concentrated and tested.
Psoralen, a DNA photocrosslinker, is the compound that P. corylifolia is best known for, but it was inactive in our assay.
The psoralen analog, bakuchicin, however was found to be a very weak topoisomerase II inhibitor. After consideration of the structure of the active compounds corylifolin and bakuchiol, resveratrol was obtained from a commercial source and tested for activity. It also had significant activity as a replicative DNA polymerase inhibitor. Resveratrol is more often studied as an antioxidant.
Skin Diseases Treatment:Babchi in Blood Cleaner
Babchi Seeds have been traditionally used as a tonic for cutaneous affections both as a topical preparation and as a food supplement to support healthy skin and promote radiant skin appearance.
Psoralens, components in psoralea, are active principles for inducing pigmentation of the skin.Supports dermal health for normal skin appearance.
They cause residual pigmentation when applied on hypo-pigmented skin, together with increased blood flow and melanin-producing activity in the affected area.
It is also used externally to treat various skin ailments including leprosy, leucoderma and hair loss. The seed and fruit contain psoralen. This causes the skin to produce new pigment when exposed to sunlight and is used for treating vitiligo and psoriasis. This has been supported by Chinese studies.
In Vietnam, a tincture of the seeds is used to treat rheumatism. It is antifungal and for most skin diseases should be taken internally and externally. For the latter, the seeds are crushed and topically applied in a poultice.
An ointment made by combining one part of an alcoholic extract of the seeds with two parts of chaulmugra oil and two parts of lanoline has been found to be effective in treating leucoderma, white leprosy, psoriasis, and other inflammatory skin diseases and febrile conditions. The oil can be used both internally or as a simple ointment externally. Gently rub the oil once or twice daily. The proportion of the active ingredients may be increased if needed.
Research has been done on using the seeds for alopecia. An injection of psoralea extracts and exposure to ultraviolet light were used in 45 cases. Within six months hair was completely resored in 36% of the cases and there was a significant restoration in another 30%.
Babchi in Blood Cleaner Mechanism:Skin conditions-especially Leukoderma, Psoriasis (used both internally and as an external paste or ointment), fevers, internal ulcers, bile conditions, improves the color of skin (including removing white spots), hair, nails; tones liver, spleen, and pancreas; impotency, frequent or involuntary urine, cold or painful extremities, joints, or lower back; difficulty breathing, diarrhea, abdominal pain.
An important use of psoralen is in PUVA treatment for skin problems such as psoriasis and (to a lesser extent) eczema and vitiligo. This takes advantage of the high UV absorbance of psoralen. The psoralen is applied first to sensitise the skin, then UVA light is applied to clean up the skin problem. Psoralen has also been recommended for treating alopecia.
Psoralea corylifolia is an important plant in the Indian Ayurveda system of medicine, and also Chinese medicine. The seeds of this plant contain a variety of coumarins including psoralen, and they have a variety of medicinal uses, but the specific role (if any) of psoralen in this unknown.
Psoralea Safety & Interaction Information:Psoralea is generally regarded as safe; however, if this herb is being used to treat a light-sensitive disorder, it is important to use sunscreen or avoid sun exposure. It is possible to experience skin irritation and blistering when using this herb topically. If that happens, discontinue use. There have also been occasional side effects such mild stomach upset, but taking ginger tea usually resolves the problem. If not, discontinue use.
Interactions:Do not use Psoralea with licorice root.
LD50.Lethal dose,50 percent kill,Oral..Rat.1330 mg/kg.
LD50,Lethal dose,50 percent kill,Subcutaneous injection.Rat.830 mg/kg.Reference:Zhong Yao Da Ci Dian(TCM Big Dictionary),by Jiang Su Xin Yi Xue Yuan,Shang Hai Science and Technology Publishing.1986.1177.
Mutagenic Data:Psoralen
Mutation in microorganisms.Bacteria-Salmonella typhimurium,16500 ug/L.Reference:JOBAAY Journal of Bacteriology.(American Soc. for Microbiology,1913 I St.,NW,Washington,DC 20006)V.1-1916-Volume(issue)/page/year:121,259,1975. Mutation in microorganisms.Bacteria-Escherichia coli.20 mg/L.Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB 211,1000AE Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:58,23,1978. DNA Damage.Bacteria-Escherichia coli;1700 ng/L.Reference:JMOBAK Journal of Molecular Biology.(Academic Press,Inc.,1 E.First St.,Buluth,MN 55802)V.1-1959-Volume(issue)/page/year:103,39,1976. Mutation in microorganisms.Yeast-Saccharomyces cerevisiae.50 umol/L.
Gene conversion and mitotic recombination.Yeast-Saccharomyces cerevisiae.50 umol/L.Reference:BUCABS Bulletin du Cancer.(SPPIF,B.P.22,F-41353 Vineuil,France)V.53-1966-Volume(issue)/page/year:67,245,1980.
Data in USA:Psoralen
EPA GENETOX PROGRAM 1988,Positive:In vitro mammalian nonhuman micronucleus.
EPA GENETOX PROGRAM 1988,Inconclusive:S cerevisiae-reversion.
Acute Toxicity:Isopsoralen
LD50.Lethal dose,50 percent kill,Intramuscular injection.Mice.180+-29.6 mg/kg.
LD50,Lethal dose,50 percent kill,Intraperitoneal injection .Mice.138.0+-10.9 mg/kg.Reference:Zhong Yi Yan Jiu Yuan Zhong Yao Yan Jiu Suo Ji Hua Sheng Yu Yan Jiu Shi.Zhong Yao Yan Jiu Zi Liao,1979,(1):16.
Scientific References:
1.This Babchi seeds or that Psoralea corylifolia,very useful phytochemicals in the future.
Claims & Warning:
Claims: Information this web site presented is meant for Nutritional Benefit and as an educational starting point only, for use in maintenance and promotion good health in cooperation with a common knowledge base reference...Furthermore,it based solely on the traditional and historic use or legend of a given herb from the garden of Adonis. Although every effort has been made to ensure its accurate, please note that some info may be outdated by more recent scientific developments......
Pharmakon Warning: The order of knowledge is not the transparent order of forms and ideas,as one might be tempted retrospectively to interpret it; it is the antidote....(Dissemination,Plato's Pharmacy,II.The Ingredients:Phantasms,Festivals,and Paints;138cf. Jacques Derrida.).
And as it happens,the technique of imitation,along with the production of the simulacrum,has always been in Plato's eyes manifestly magical,thaumaturgical:......and the same things appear bent and straight to those who view them in water and out,or concave and convex,owing to similar errors of vision about colors, and there is obviously every confusion of this sort in our souls.And so scene painting (skiagraphia) in its exploitation of this weakness of four nature falls nothing short of witchcraft (thaumatopoia), and so do jugglery and many other such contrivances.(Republic X,602c-d;cf.also 607c).
seminal trace...Psoralea fruit Extract.Babchi seed extract.Psoralea corylifolia seed extract,Psoralea extract.10:1.Psoralen,C17H18O6,CAS No:10523-56-5; isopsoralen,C11H6O3,CAS No:523-50-2...
Basic Botanical and Description of Babchi seeds,Psoralea corylifolia:
Benefits of psoralea for specific health conditions include the following:
As hair tonic: In the treatment of leucoderma, leprosy, scabies, dermatatis, vitiated pitta and muco memberanous disorders.
Scientific References:
Claims & Warning:
