5-HTP:5-Hydroxytryptophan.:Introduction and Its Benefit Applications.

5-Hydroxytryptophan Safety and Toxicity.

5-HTP:5-Hydroxytryptophan CAS 56-69-9 EINECS ELINCS No 200-284-8 photo picture image Safety: Side effects of 5-HTP may include nausea, constipation, gas, drowsiness, decreased sex drive, anxiety, numbness, paresthesia, breathing problems, palpitations, chest pain, hallucinations and insomnia. 5-HTP can also have adverse interactions with other natural and traditional drugs.

Acute Toxicity:

LD50-lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.200 mg/kg.Details of toxici effects not reported other than lethal dose value.Reference:NTIS**National Technical Information Service.(Springfield,VA 22161).Formerly U.S.Clearinghouse for Scientific and Technical Information.Volume(issue)/page/year:AD277-689.

Reproductive Data:

TDLo-Lowest published toxic dose.Intraperitoneal.Rodent-rat.30 mg/kg.Sex/Duration:male 1 day(s) pre-mating.

Toxic Effects:Reproductive-Fertility-mating performance (e.g.#sperm positive females per # females mated;#copulations per # estrus cycles).ANENAG Annales d'Endocrinologie.(Masson Editeur,120 Blvd.Saint-German,F-25280 Paris Codex 06,France) V.1-1939-Volume(issue)/page/year:24(Suppl 3),1,1963.

General Description:

TOXICOLOGY REVIEW.CLPTAT Clinical Pharmacology and Therapeutics (St.Louis).(C.V.Mosby Co.,11830 Westline Industrial Dr.,St.Louis,MO 63146)V.1-1960-Volume(issue)/page/year:5,480,1964.

Report in USA:

EPA TSCA Section 8(b) CHEMICAL INVENTORY

Possible risks or side effects:

Because 5-HTP has not been thoroughly studied in a clinical setting, possible side effects and interactions with other drugs are not well known, however it has been sold since the 1990's in the US otc without any serious problems reported.

Due to the conversion of 5-HTP into serotonin by the liver, there is a possible yet unproven risk of heart valve disease from serotonin's effect on the heart.

Direct and indirect evidence for possible yet unproven risks and side effects associated with 5-HTP when overdosed:

In people:

Heart valve damage or disease.
When combined with MAO inhibitors, MDMA, Methylone, SSRIs, or other serotoninergic drugs 5-HTP may cause acute serotonin syndrome.

When combined with carbidopa (as a treatment for symptoms of Parkinson's disease), 5-HTP causes nausea and vomiting; however this can be alleviated via administration of granisetron.