Daidzein:4',7-Dihydroxyisoflavone.:Introduction and Its Benefit Applications.

Introduction:Daidzein.

Daidzein:4',7-Dihydroxyisoflavone,CAS:486-66-8 EINECS ELINCS No 207-635-4 isoflavonoid,weak estrogenic and weak anti-estrogenic,Anti-carcinogenic,Anti-osteoporotic photo picture image Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. The estimated human normal dietary intake of daidzein, primarily as glycosides, is 0 to 0.3 mg/kg. Daidzein is present in much greater amounts in nutritional supplements. Daidzein is inactive as a tyrosine-specific inhibitor of protein kinase activity, and can be used as a negative control for genistein. In adult animals, dietary genistein has numerous effects based on estrogen agonist/antagonist and antioxidant activities.

Daidzein belongs to the group of isoflavones and has the typical C6-C3-C6 structure. Isoflavones are also called phytoestrogens because they have some estrogen activity. Daidzein is the aglycone (molecule without sugar) of glycoside daidzin. Other well known isoflavones are genistein and glycitein.

Daidzein is one of several known isoflavones. Isoflavones compounds, such as daidzein and genistein, are found in a number of plants and herbs like the Thai Kwao Krua or Pueraria Mirifica, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidants, many isoflavones have been shown to interact with animal and human estrogen receptors, and are therefore known as phytoestrogens. Soy isoflavones also produce non-hormonal effects.

Isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues. Isoflavones can act like estrogen in stimulating development and maintenance of female characteristics or they can block cells from using other forms of estrogen[citation needed]. Isoflavones also have been found to have antiangiogenic effects (blocking formation of new blood vessels), and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors).

Studies show that groups of people who eat large amounts of soy-based products have lower incidences of breast, colon, endometrial, and prostate cancers than the general (US) population[citation needed]. Initial studies of soy and Kwao Krua isoflavone mixtures containing genistein, daidzein, and glycitein have found them safe for human use. Laboratory studies using animals models have shown that both soy and isoflavones can be protective against cancer when given during early life but can stimulate response to cancer-causing chemicals when given during fetal development or when circulating levels of estrogen are low (menopause).

White Kawo Krua, Pueraria mirifica has been found to contain concentrations of daidzein where the Cu2+ at 300 ppm is shown to contain as much as 44.69 ppm of daidzein. Another source of daidzein is Kudzu, Pueraria Lobata.