Ecdysterone:20-hydroxyecdysone.:Introduction and Its Benefit Applications.

Common Benefits of Ecdysterone.

Ecdysterone:20-hydroxyecdysone CAS 5289-74-7 ecdysteroid hormone body building photo picture image Main Benefits: Research indicates that Ecdysterone may be useful in the treatment of:

Cardiovascular disease
Fatigue/Weakness
Catabolism (muscle wasting)
Impaired immune function
Sperm mobility
A Drastic Increase in Lean Body Mass
Increased Endurance
Stimulates Metabolism
Improves Nerve Function and Enhances Erythropoiesis (the development of mature red blood cells (erythrocytes))
Maintains Healthy Blood Sugar
Reduces Adipose Tissue
Improves Nearly Every Bodily Function Including Brain and Liver
It's Safe and Effective for Men, Women, and Even Teenagers
Prevents the Loss of Muscle Mass while Promoting Growth of Muscle Fibers
Increases protein synthesis
Improves nearly every bodily function
Stimulates protein synthesis in nervous tissue and increases nerve function
Increases growth anabolicly in vertebrates including humans
Increases total protein and glycogen content in muscles
Increases myofibrilar proteins more efficiently than the anabolic steroids Methandrostenolone, the most potent steroid, Dianabol
Suppresses hypoglycemia while powerfully stabilizing blood sugar levels
Perfect glycemic regulator leading to constant energy and feeling of well-being
Stimulates incorporation of glycogen into proteinaceous tissue such as liver and muscle
Prevents high blood sugar levels and high insulin levels thereby halting fat production
Pushes nutrients into muscle and organ tissue yielding better muscle growth and repair
Possesses potent cholesterol-lowering effect.
Stimulates the phospholipids that are linked to enormous health benefits when stimulated
Lowers cholesterol having a potent hepatoprotective action.
Cell membrane stabilizing properties
Analgestic properties and a potent antioxidative effect
Anti-arrhythmia stabilizing properties.
Powerful anti-inflammatory properties
Positive effect on the skin improving: keratinization, differentiation and acne.
Works against high cortisol levels as an anti-catabolic agent by reducing stressors such as inflammation, preventing cortisol from being released
Vastly increases athletic performance by increasing work capacity, body-weight, lung capacity, and VO2 max while also increasing exhalation of CO2.
Increases lean muscle tissue and reduces adipose content
Reduces fatigue and apathy, yet increases speed and strength
Promotes a positive nitrogen balance and maintains a greater rate of protein synthesis

Additional Note:

In addition to its potential use as an anabolic growth hormone, 20-hydroxyecdysone has proven to cause moderate increases in testosterone production in males.This has led to speculation and a small number of partially successful trials in testing its use in improving overall sexual function.

It is unclear whether 20-hydroxyecdysone actually has any effect on humans. It is used widely in biochemistry research as a transcription promoter in transgenic animals, whereby if you put a new gene into an animal with a promoter sequence that is activated by 20-hydroxyecdysone, then adding or removing 20-hydroxyecdysone from the animals diet gives a convenient way to turn the inserted gene on or off. 20-hydroxyecdysone appears to have little or no effect on animals that do not have extra genes inserted and has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively.

However there is some evidence to show that 20-hydroxyecdysone has effects on some kinds of blood cells such as lymphocytes and neutrophils, and may act as an immunomodulator. More research is needed to determine the significance of these effects and how they affect the safety profile of 20-hydroxyecdysone when it is taken as a supplement by humans.
20-hydroxyecdysone is still considered a steroid "hormone" and may cause side effects that normal steroids produce.
Any types of supplements containing 20-hydroxyecdysone should not be taken by anyone under the age of 18.

Ecdysteroid activity in arthropods:

Ecdysteroid is a term used to describe a group of steroid hormones in insects that are derived from enzymatic modification of cholesterol by p450 enzymes. This occurs by a mechanism similar to steroid synthesis in vertebrates. Ecdysone and 20-hydroxyecdysone (20E) regulate larval molts, onset of puparium formation, and metamorphosis. Being that these hormones are hydrophobic, they traverse lipid membranes and permeate the tissues of an organism. Indeed, the main receptor of these hormone signals - the ecdysone receptor - is an intracellular protein.

Consumption:

When first isolated, there was little interest from the commercial sector due to the lack of a cost-effective way to extract or synthesize the chemical. However, recent breakthroughs have meant that it can now be isolated in an extremely concentrated form. This has led to experimentation with its use as an anabolic steroid in sport and bodybuilding.

Despite lacking FDA approval, it has proven to be moderately successful as a commercial product in the countries in which it is produced, likely due to its efficacy in promoting muscle growth and fat loss, and lower frequency of side-effects usually associated with anabolic steroids. Such side effects are still fairly common, however, as a result of increased testosterone and DHT production, and include androgenic changes in females such as growth of facial and body hair and deepening of the voice, as well as gastrointestinal problems for both sexes, such as nausea, bloating, and diarrhoea. Clinical studies by ICN Pharmaceuticals demonstrated that the results are further improved when the drug is combined with a high-protein diet, to the point of equaling or even surpassing the beneficial effects of conventionally derived steroids such as Dianabol. The same studies showed the effective dose for a human to be around 5 mg per kg of body mass, daily. The compound becomes toxic only at doses of 6400 mg per kg of body mass per day.

In addition to its potential use as an anabolic growth hormone, 20-hydroxyecdysone has proven to cause moderate increases in testosterone production in males.This has led to speculation and a small number of partially successful trials in testing its use in improving overall sexual function.

There is also some evidence to show that 20-hydroxyecdysone has effects on some kinds of blood cells such as lymphocytes and neutrophils, and may act as an immunomodulator .

An academic review published in 2003 concluded that "The impressive development of preparations containing ecdysteroids suggests that this class of molecule has indeed at least some of the claimed effects. The scientific justification for such commercial developments relies, however, on just a few references (ca. 10), often with the same ones being cited to support quite different effects".

Clearly, more research is needed to determine the significance of the effects of 20-hydroxyecdysone in mammals and how they affect the safety profile of 20-hydroxyecdysone when it is taken as a dietary supplement by humans. 20-hydroxyecdysone is still considered a steroid "hormone" and may cause side effects that normal steroids produce.

Research tool

20E (and other ecdysteroids) are used in biochemistry research as inducers in transgenic animals, whereby if you put a new gene into an animal so that its expression is under the control of an introduced ecdysone receptor, then adding or removing 20-hydroxyecdysone from the animal's diet gives a convenient way to turn the inserted gene on or off (Ecdysone receptor). At usual doses, 20-hydroxyecdysone appears to have little or no effect on animals that do not have extra genes inserted; it also has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively. For uses in gene therapy, it may be necessary to investigate more thoroughly the natural sources of ecdysteroids in humans (which appear to include dietary phytoecdysteroids, gut flora, helminth infections, and other diseases).

Reference:

1.Ecdysterone:20-hydroxyecdysone.:Introduction and Its Benefit Applications.

last edit date:11th,Mar.2010.

Available Product

Name:Ecdysterone
Serie No:Pure09.
Specifications:95%HPLC.
INCI Name:N/A
EINECS/ELINCS No.:N/A
CAS:5289-74-7
Chem/IUPAC Name:(2beta,3beta,5beta,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one

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