Genistein:4',5,7-Trihydroxyisoflavone.:Introduction and Its Benefit Applications.

Genistein Safety and Toxicity.

Genistein:4',5,7-Trihydroxyisoflavone CAS 446-72-0 EINECS ELINCS No 207-174-9 isoflavone,flavonoids,phytoestrogens,antioxidant photo picture image Acute toxicity(LD50):Genistein.

LD-Lethal dose,Intraperitoneal.Rodent-mouse.>500mg/kg.Details of toxic effects not reported other than lethal dose value.Reference: JANTAJ Journal of Antibiotics.V.2-5,1948-52;V.21-1968-Volume(issue)/page/year:39,606,1986.

Reproductive Data:

TDLo-Lowest published toxic dose.Subcutaneous.Rodent-rat.125mg/kg.Sex/Duration:female 16~20days(s) after conception.Toxic Effects: Reproductive-Specific Development Abnormalities-urogenital system.Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.

TDLo-Lowest published toxic dose.subcutaneous.Rodent-rat.625mg/kg.Sex/Duration:female 16~20 day(s) after conception.Toxic Effects: Reproductive-Effects on Newborn-growth statistics(e.g.%,reduced weight gain).Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.

TDLo-Lowest published toxic dose.Oral.Rodent-mouse.1680mg/kg.Sex/Duration:female 21 day(s) pre-mating.Toxic Effects:Reproductive.Maternal Effects.other effects.Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.

TDLo-Lowest published toxic dose.Oral.Rodent-mouse.13200mg/kg.Sex/Duration:male 22 day(s) pre-mating.Toxic Effects: Reproductive-fertility-male fertility index(e.g.#males impregnating females per#males exposed to fertile nonpregnant females).Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.

TDLo-Lowest published toxic dose.Oral.Rodent-mouse.18600mg/kg.Sex/Duration:male 31 day(s) pre-mating.Toxic Effects: Reproductive-Effects on Newborn-stillbirth.Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.
Genistein:4',5,7-Trihydroxyisoflavone CAS 446-72-0 EINECS ELINCS No 207-174-9 isoflavone,flavonoids,phytoestrogens,antioxidant photo picture image

Mutagenic Data.

DNA damage.Test system:Human Cells-not otherwise specified.50mg/L.Reference: CNREA8 Cancer Research.(Public Ledger Building,Suit 816,6th Chestnut Sts.,Philadelphia,PA 19106)V.1-1941-Volume(issue)/page/year:50,2618,1990.

DNA damage.Test system:Human Cells-not otherwise specified.50umol/L.Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.

Mutation test systems-not otherwise specified.Test system:Human Cells-not otherwise specified.45 umol/L.Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.

Micronucleus test.Test sytem:Rodent-hamster Lung.18 umol/L.Reference:FCTOD7 Food and Chemical Toxicology.(Pergamon Press Inc.Maxwell House,Fairview Park,Elmsford,NY 10523) V.20-1982-Volume(issue)/page/year:35,605,1997.