Resveratrol,Trans-3,5,4'-trihydroxystilbene,Introduction and Its Benefit Applications.
Resveratrol Safety and Toxicity.:
Studies General Safety of Resveratrol:
Human Studies:Adverse effects of resveratrol have not been reported:a recommended dosage of 5~10 mg(22~44 umol) per day was stated to be "entirely safe."Recently,the National Cancer Institute(NCI) initiated preclinical toxicity studies on trans-resveratrol: clinical trials may also be conducted.
Short-term and Subchronic Exposure:
In rats,daily oral administration of resveratrol (300,1000, and 3000 mg/kg [1.31,4.381, and 13.14 mmol/kg]) for 28 days produced nephrotoxicity,dehydration,labored breathing,hunched posture,decreased activity, rough coat,diarrheam,soft stool, and red material around the nose at the high dose.Males also had leukocytosis, and both sexes may have had anemia.Based on the results, the no observed adverse effect level (NOAEL) was 300 mg/kg/day.
In hypercholesterolemic rabbits, trans-resveratrol(0.06 mg/kg [0.3 umol/kg] during days 1~5 and 1.0 mg/kg[4.4 umol/kg] from days 6~60) promoted atherosclerosis.
Reproductive and Teratological Effects:
In developing white Leghorn chick embryos, resveratrol (1,10,25,50 and 100 ug/disk[0.004,0.044,0.11,0.22, and 0.438 umol/disk] incubated for 48~72 hours) induced vascular zones in the developing chorioallantoic membrane.
- 1.Resveratrol,Trans-3,5,4'-trihydroxystilbene,Introduction and Its Benefit Applications.
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