Ursolic acid:(3Beta)-3-hydroxyurs-12-en-28-oic acid.:Introduction and Its Benefit Applications.
Contents
Common Benefits of Ursolic acid.:
Pharmacological Action: Anti-Infective Agents,Antineoplastic Agents,Phytogenic; Cyclooxygenase Inhibitors.
Inhibition of Tumor Promotion in skin:
Ursolic acid (UA) and oleanolic acid (OA), isolated from Glechoma hederacea, inhibited Epstein-Barr virus activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse skin. The inhibitory effects were evaluated for 20 weeks. Continuous application of UA and OA (41 nmol of each) before TPA-treatment (4.1 nmol) delayed the formation of papillomas in mouse skin and reduced the rate (%) of papilloma bearing mice. Both UA and OA exhibited remarkable inhibitory activity against tumor promotion, which is comparable to the known tumor inhibitor, retinoic acid (RA). Compared to either RA or OA, ursolic acid inhibited tumor more effectively after a single application before initial TPA-treatment as shown in Figure 1. This suggests that the role of tumor inhibition by UA differs from that of either RA or OA. It is suggested that pretreatment of skin with UA may inhibit the first dramatic cellular event in tumor promotion caused by TPA.
Hair Growth Stimulant:
Ursolic acid and its isomer, oleanolic acid, have been used in to nics to enhance hair growth and prevent scalp irritation. Both triterpenoid compounds encourage hair growth by stimulating the peripheral blood flow in the scalp and activating the hair mother cells. They also furnish alopecia-preventing and dandruff-preventing effects.
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Antimicrobial Activity:
Beta ursolic acid (triterpenoid sapogenin from the ursan group) inhibited the growth of several strains of staphylococci. Numerous ursolic acid containing plants from the Lamiaceae family exhibited antibacterial/ fungal activity. The minimal inhibitory concentration of Rosmarinus officinalis, Origanum majorana, and Lavandula officinalis were 500, 250, and 500 mg/cm3, respectively. Ursolic acid also inhibited the growth of Microsporium lenosum and Candida albicans at 250 mg/mL.
Anti-Aging Agent:
Ursolic acid treatment improves the health of skin and hair. Ursolic acid and its derivatives form oil-resistant barriers on the skin and hair as they do in the waxy coating of fruits. Ursolic acid has been used to treat photoaged skin because it prevents and improves the appearance of wrinkles and age spots by restoring the skin's collagen bundle structures and its elasticity. Concentrations of ursolic acid ranging from 0.01 to 50 mg have been reported for inclusion in skin treatment preparations
Anti-Inflammatory Activity:
Ursolic acid is a potent anti-inflammatory agent. Thus, it has been recommended for use in burn ointments. It not only inhibits human leucocyte elastase(HLE), but also 5-lipoxygenase and cyclooxygenase activity. Ursolic acid (1.0 mg/ear) inhibited TPA-induced mouse ear edema by 72.4%23. Hirota and coworkers24 determined that 200 mg and 50 mg applications of ursolic acid inhibited 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (HPPA) - induced inflammation by 49% and 33%, respectively. In addition, it inhibited concanavalin A (Con A) induced histamine release, which can cause severe inflammation, by 95% at a concentration of 0.001 M.
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Reference:
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- 1.Ursolic acid:(3Beta)-3-hydroxyurs-12-en-28-oic acid.:Introduction and Its Benefit Applications.
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