Goldenseal Root,Echinacea's partner, broad-spectrum herbs and its uses.

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Phytochemicals and Constituents.

Golden Seal Root Extract INCI Name Hydrastis Canadensis Root Extract CAS 84603-60-1 EINECS ELINCS No 283-261-5 photo picture image Goldenseal contains a compound called berberine that kills many types of bacteria, including the ones that cause diarrhea. Berberine has also been shown to kill a wide range of other types of germs, such as those that cause candida (yeast) infections, viruses, and various parasites such as tapeworms and Giardia. Berberine may also activate white blood cells, making them more effective at fighting infection and strengthening the immune system. For these reasons, berberine is used as an antibiotic and disinfectant, both externally and internally. Berberine may also be useful in heart failure and malaria.

 Goldenseal Root Holistic Extract Containing: Water, Glycerol, Root Extractives, 15% Grain Alcohol (left after extraction as a preservative), Triacetic Glycerol, phosphatidylcholine (Lecithin), Mixed Tocopherols (a Natural source of Vitamin E), less than 1% Gum Arabic and/or Sodium Caseinate (protein) as emulsifiers.

 Constituents: 5% of the root consists of isoquinoline alkaloids )hydrastine, berberine and canadine) chlorogenic acid, traces of essential oil, resin, fatty oil, starch, sugar

 The two primary alkaloids are hydrastine and berberine, along with smaller amounts of canadine. Berberine, which ranges from 0.5-6.0% of the alkaloids present in goldenseal root and rhizome, has been the most extensively researched. It appears to have a wide spectrum of antibiotic activity against pathogens, such as Chlamydia species, E. coli, Salmonella typhi, and Entomeba histolytica.

 Major Constituents:

 The two primary alkaloids are hydrastine and berberine, along with smaller amounts of canadine. Berberine, which ranges from 0.5-6.0% of the alkaloids present in goldenseal root and rhizome, has been the most extensively researched. It appears to have a wide spectrum of antibiotic activity against pathogens, such as Chlamydia species, E. coli, Salmonella typhi, and Entomeba histolytica.

 Vitamines and Minerals: Goldenseal contains calcium, iron, manganese, vitamin A, vitamin C, vitamin E, B-complex, and other nutrients and minerals.

 Alkaloids: For an herb with such a tremendous medicinal reputation, there has been very little research into its pharmacology, but it is known that goldenseal's medicinal actions are due largely to the isoqinoline alkaloids.

 Hydrastine: Research in Canada in the late 1960s showed that hydrastine constricts the blood vessels and stimulates the autonomic nervous system.

 Berberine: Berberine is bitter, antibacterial, and amebicidal. It also has a sedative action on the central nervous system.

 Canadine: Research shows that this alkaloid stimulates the muscles of the uterus.

 A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis:

 A new compound, 5-O-(4'-[beta-d-glucopyranosyl]-trans-feruloyl)quinic acid (GPFQ, 10), is reported from the medicinal plant goldenseal (Hydrastis canadensis). A new HPLC method is described and used to show that GPFQ is a potential marker for goldenseal roots (1.0% w/w) and rhizomes (2.3%). GPFQ was found at much lower levels in stems (less than 0.1%) and could not be detected in leaves.

 Neochlorogenic acid (9), which has not previously been reported from goldenseal,and chlorogenic acid (6) reached their highest levels in leaves (0.9% 9 and 0.5% 6). The main alkaloids, hydrastine (1) and berberine (2), were highest in rhizomes (2.8% 1 and 4.6% 2), but palmatine (5) was not found in genuine goldenseal.

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Reference:

citations1.Goldenseal Root,Echinacea's partner, broad-spectrum herbs and its uses.

last edit date:19th,June.2009.